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Kumari S, Panda S, Mangaraj M, et al. Plasma MDA and antioxidant vitamins in diabetic retinopathy. Indian J Clin Biochem. 2008;23(2):158-62doi: 10.1007/s12291-008-0035-1.
Kumari, S., Panda, S., Mangaraj, M., Mandal, M. K., & Mahapatra, P. C. (2008). Plasma MDA and antioxidant vitamins in diabetic retinopathy. Indian journal of clinical biochemistry : IJCB, 23(2), 158-62. https://doi.org/10.1007/s12291-008-0035-1
Kumari, S, et al. "Plasma MDA and antioxidant vitamins in diabetic retinopathy." Indian journal of clinical biochemistry : IJCB vol. 23,2 (2008): 158-62. doi: https://doi.org/10.1007/s12291-008-0035-1
Kumari S, Panda S, Mangaraj M, Mandal MK, Mahapatra PC. Plasma MDA and antioxidant vitamins in diabetic retinopathy. Indian J Clin Biochem. 2008 Apr;23(2):158-62. doi: 10.1007/s12291-008-0035-1. Epub 2008 Jun 11. PMID: 23105743; PMCID: PMC3453080.
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Indian J Clin Biochem. 2008 Apr;23(2):158-62. doi: 10.1007/s12291-008-0035-1. Epub 2008 Jun 11.

Plasma MDA and antioxidant vitamins in diabetic retinopathy.

Indian journal of clinical biochemistry : IJCB

S Kumari, S Panda, M Mangaraj, M K Mandal, P C Mahapatra

Affiliations

  1. Department of Biochemistry, SCB Medical College, Cuttack, 753007 Orissa India.

PMID: 23105743 PMCID: PMC3453080 DOI: 10.1007/s12291-008-0035-1

Abstract

Hyperglycemia and dyslipidemia in diabetes mellitus induce increased lipid peroxidation and peroxyl radical formation, an important mechanism in genesis of microangiopathy. We took up a study on oxidative stress, measured by plasma MDA and antioxidant vitamin status in type - 2 DM patients with and without retinopathy and compared them with a control non-diabetic group. Lipid peroxidation marker MDA was significantly elevated (p < 0.001) in both the diabetic groups whereas, serum vitamin E and vitamin C registered a significant fall (p<0.001) as compared to controls. Our correlation study revealed a significant positive association between plasma MDA with both fasting and 2hr post prandial plasma glucose (r=0.81, p < 0.001, r=0.92, p <0.001) suggesting the role of hyperglycemia in free radical production. Plasma MDA also depicted significant positive relation (p< 0.001) with all lipid parameters except serum HDLc pointing the role of dyslipidemia towards lipid peroxidation. Plasma MDA level was also found to be negatively correlated with both the vitamins (p<0.001, p<0.001) in the study group explaining their protective consumption in the oxidative process prevailing in diabetic retinopathy.

Keywords: Microangiopathy; Oxidative stress; Peroxy radical

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