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F1000 Med Rep. 2012;4:22. doi: 10.3410/M4-22. Epub 2012 Nov 01.

Neuromodulation for treatment-resistant depression.

F1000 medicine reports

Paul E Holtzheimer, Helen S Mayberg

Affiliations

  1. Departments of Psychiatry and Surgery, Dartmouth-Hitchcock Medical Center 5D, One Medical Center Drive, Lebanon NH 03756, USA.

PMID: 23189091 PMCID: PMC3506219 DOI: 10.3410/M4-22

Abstract

Treatment-resistant depression affects at least 1-3% of the US population. This article reviews the current state of focal neuromodulation therapies for treatment-resistant depression, focusing on those treatments published clinical data. These include transcranial magnetic stimulation, transcranial direct current stimulation, magnetic seizure therapy, vagus nerve stimulation, direct cortical stimulation, and deep brain stimulation among others. Of these, only two (transcranial magnetic stimulation and vagus nerve stimulation) currently have US Food and Drug Administration approval for the treatment of depression.

References

  1. Br J Psychiatry. 2003 Jun;182:480-91 - PubMed
  2. Arch Gen Psychiatry. 2010 May;67(5):507-16 - PubMed
  3. J Clin Psychiatry. 2011 Oct;72(10):1376-82 - PubMed
  4. Biol Psychiatry. 2009 Feb 15;65(4):267-75 - PubMed
  5. World J Biol Psychiatry. 2011 Mar;12(2):119-26 - PubMed
  6. J ECT. 2011 Mar;27(1):18-25 - PubMed
  7. PLoS One. 2009 Aug 21;4(8):e6725 - PubMed
  8. Clin Neurophysiol. 2009 Jun;120(6):1174-82 - PubMed
  9. Int J Neuropsychopharmacol. 2000 Jun;3(2):129-134 - PubMed
  10. Arch Gen Psychiatry. 2006 Dec;63(12):1337-44 - PubMed
  11. Mov Disord. 2002 May;17(3):528-32 - PubMed
  12. Biol Psychiatry. 2007 Dec 1;62(11):1208-16 - PubMed
  13. Arch Womens Ment Health. 2010 Aug;13(4):369-70 - PubMed
  14. J Womens Health (Larchmt). 2011 Feb;20(2):255-61 - PubMed
  15. Psychol Med. 2010 Nov;40(11):1789-95 - PubMed
  16. Am J Psychiatry. 2006 Jan;163(1):88-94 - PubMed
  17. Neuropsychopharmacology. 2008 Jan;33(2):368-77 - PubMed
  18. Clin Neurophysiol. 2007 Dec;118(12):2730-44 - PubMed
  19. Aust N Z J Psychiatry. 1997 Aug;31(4):457-64 - PubMed
  20. Neuropsychopharmacology. 2003 Nov;28(11):2045-8 - PubMed
  21. J Neuropsychiatry Clin Neurosci. 2010 Summer;22(3):265-77 - PubMed
  22. Arch Gen Psychiatry. 1999 Apr;56(4):300-11 - PubMed
  23. Mol Psychiatry. 2010 Jan;15(1):64-79 - PubMed
  24. J Clin Psychiatry. 2010 Apr;71(4):504-6 - PubMed
  25. J Clin Psychiatry. 2008 Jun;69(6):930-4 - PubMed
  26. JAMA. 2001 Mar 14;285(10):1299-307 - PubMed
  27. Depress Anxiety. 2012 Oct;29(10):883-90 - PubMed
  28. Epilepsy Res. 2001 Nov;47(1-2):37-42 - PubMed
  29. Neuroreport. 1995 Oct 2;6(14):1853-6 - PubMed
  30. Bipolar Disord. 1999 Dec;1(2):73-80 - PubMed
  31. J Psychiatr Res. 2011 May;45(5):569-76 - PubMed
  32. Bipolar Disord. 2006 Apr;8(2):203-4 - PubMed
  33. J ECT. 2011 Mar;27(1):26-32 - PubMed
  34. J Nerv Ment Dis. 2008 May;196(5):405-10 - PubMed
  35. Arch Gen Psychiatry. 2005 Jun;62(6):617-27 - PubMed
  36. J Psychiatr Pract. 2002 Sep;8(5):270-5 - PubMed
  37. J Neurol Neurosurg Psychiatry. 2004 Feb;75(2):320-2 - PubMed
  38. Psychol Med. 2008 May;38(5):651-61 - PubMed
  39. J ECT. 2010 Dec;26(4):323-9 - PubMed
  40. Anesth Analg. 2006 Jul;103(1):76-80, table of contents - PubMed
  41. Can J Public Health. 1989 May-Jun;80(3):221-5 - PubMed
  42. Am J Psychiatry. 2007 Jul;164(7):1118; author reply 1118-9 - PubMed
  43. J ECT. 2011 Dec;27(4):310-4 - PubMed
  44. Brain Res Bull. 2007 May 30;72(4-6):208-14 - PubMed
  45. J ECT. 2008 Jun;24(2):156-9 - PubMed
  46. Australas Psychiatry. 2006 Mar;14(1):81-5 - PubMed
  47. J ECT. 2005 Jun;21(2):88-95 - PubMed
  48. Brain Stimul. 2012 Jul;5(3):242-251 - PubMed
  49. Neuropsychopharmacology. 2009 Jul;34(8):2002-10 - PubMed
  50. Biol Psychiatry. 2010 Jan 15;67(2):e9-e11 - PubMed
  51. Brain Stimul. 2010 Oct;3(4):187-99 - PubMed
  52. J Dermatol Surg Oncol. 1988 Jun;14(6):664-7 - PubMed
  53. Lancet. 1996 Jul 27;348(9022):233-7 - PubMed
  54. J Neurosurg. 2012 Feb;116(2):315-22 - PubMed
  55. Biol Psychiatry. 2005 Sep 1;58(5):347-54 - PubMed
  56. Neurosurgery. 2011 Nov;69(5):1015-29; discussion 1029 - PubMed
  57. Exp Neurol. 2009 Sep;219(1):14-9 - PubMed
  58. Neuropsychopharmacology. 2006 Jul;31(7):1345-55 - PubMed
  59. Biol Psychiatry. 2006 Jan 15;59(2):187-94 - PubMed
  60. Epilepsy Behav. 2000 Apr;1(2):93-99 - PubMed
  61. Contemp Clin Trials. 2011 Jan;32(1):90-8 - PubMed
  62. Adv Neurol. 1995;66:97-114 - PubMed
  63. Br Med Bull. 2003;65:193-207 - PubMed
  64. Neuron. 2005 Mar 3;45(5):651-60 - PubMed
  65. Epilepsy Res. 2000 Dec;42(2-3):203-10 - PubMed
  66. Neuropsychopharmacology. 2001 Nov;25(5):713-28 - PubMed
  67. Int J Neuropsychopharmacol. 2010 Apr;13(3):387-93 - PubMed
  68. J Affect Disord. 2008 Aug;109(3):273-85 - PubMed
  69. Biol Psychiatry. 2010 Jan 15;67(2):110-6 - PubMed
  70. Psychol Med. 2003 Jan;33(1):33-40 - PubMed
  71. Psychopharmacol Bull. 2001 Autumn;35(4):149-69 - PubMed
  72. Psychiatry Res. 2010 May 30;177(3):280-5 - PubMed
  73. Trends Neurosci. 2011 Jan;34(1):1-9 - PubMed
  74. Psychiatr Clin North Am. 1997 Dec;20(4):933-43 - PubMed
  75. Neuro Endocrinol Lett. 2008 Feb;29(1):69-70 - PubMed
  76. Biol Psychiatry. 2000 Dec 15;48(12):1133-41 - PubMed
  77. Biol Psychiatry. 2011 Apr 15;69(8):e23-4 - PubMed
  78. Int J Neuropsychopharmacol. 2010 Feb;13(1):61-9 - PubMed
  79. Int J Neuropsychopharmacol. 2006 Dec;9(6):667-76 - PubMed
  80. J ECT. 2010 Mar;26(1):68-9 - PubMed
  81. Biol Psychiatry. 2005 Sep 1;58(5):355-63 - PubMed
  82. Neuropsychiatr Dis Treat. 2006 Mar;2(1):85-94 - PubMed
  83. J Clin Psychiatry. 2005 Sep;66(9):1097-104 - PubMed
  84. Biol Psychiatry. 2010 Jul 15;68(2):163-9 - PubMed
  85. Neuropsychopharmacology. 2003 Oct;28(10):1852-65 - PubMed
  86. J ECT. 2009 Mar;25(1):44-9 - PubMed
  87. J Clin Psychiatry. 2010 Jul;71(7):873-84 - PubMed
  88. J Clin Invest. 2009 Apr;119(4):717-25 - PubMed
  89. Br J Psychiatry. 2012 Jan;200(1):52-9 - PubMed
  90. Int J Neuropsychopharmacol. 2002 Mar;5(1):73-103 - PubMed
  91. Neurosurgery. 2005 Sep;57(3):585-93; discussion 585-93 - PubMed
  92. Biol Psychiatry. 2002 Feb 15;51(4):280-7 - PubMed
  93. Brain Stimul. 2011 Jan;4(1):17-27 - PubMed
  94. Neuropsychiatr Dis Treat. 2007 Dec;3(6):919-24 - PubMed
  95. Arch Gen Psychiatry. 2008 Mar;65(3):268-76 - PubMed
  96. Biol Psychiatry. 2002 Apr 15;51(8):687-90 - PubMed
  97. Neurosurg Focus. 2010 Aug;29(2):E1 - PubMed
  98. Hum Psychopharmacol. 2002 Oct;17(7):353-6 - PubMed
  99. Brain Stimul. 2009 Oct;2(4):188-200 - PubMed
  100. Am J Psychiatry. 2006 Nov;163(11):1905-17 - PubMed
  101. Depress Anxiety. 2010 Oct;27(10):960-3 - PubMed
  102. Brain Stimul. 2010 Jul;3(3):181-3 - PubMed
  103. Am J Psychiatry. 2007 Jan;164(1):73-81 - PubMed
  104. Clin Neurophysiol. 2005 Apr;116(4):775-9 - PubMed
  105. Electroencephalogr Clin Neurophysiol. 1998 Jan;108(1):1-16 - PubMed
  106. Arch Gen Psychiatry. 2012 Feb;69(2):150-8 - PubMed
  107. Int J Neuropsychopharmacol. 2007 Dec;10(6):817-26 - PubMed
  108. Psychol Med. 2009 Jan;39(1):65-75 - PubMed
  109. Evid Based Ment Health. 2007 Aug;10(3):78 - PubMed
  110. Biol Psychiatry. 2003 Feb 15;53(4):324-31 - PubMed
  111. Psychopharmacol Bull. 1992;28(3):261-74 - PubMed
  112. J Clin Psychopharmacol. 2010 Jun;30(3):273-81 - PubMed
  113. J Neuropsychiatry Clin Neurosci. 1998 Winter;10(1):20-5 - PubMed
  114. Int J Neuropsychopharmacol. 2012 Feb;15(1):121-33 - PubMed
  115. Int J Geriatr Psychiatry. 2004 Sep;19(9):833-42 - PubMed
  116. Am J Psychiatry. 2011 May;168(5):502-10 - PubMed
  117. Neuropsychopharmacology. 2012 Aug;37(9):1975-85 - PubMed
  118. Biol Psychiatry. 2010 Jan 15;67(2):101-9 - PubMed
  119. Arch Gen Psychiatry. 1999 Apr;56(4):315-20 - PubMed
  120. J Child Adolesc Psychopharmacol. 2001 Spring;11(1):69-75 - PubMed
  121. Biol Psychiatry. 2008 Sep 15;64(6):461-7 - PubMed
  122. Biol Psychiatry. 2004 Feb 15;55(4):398-405 - PubMed
  123. Brain Stimul. 2010 Jan;3(1):36-41 - PubMed
  124. Biol Psychiatry. 2000 Feb 15;47(4):314-24 - PubMed
  125. Biol Psychiatry. 2005 Sep 1;58(5):364-73 - PubMed

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