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Eberle MM, Reynolds CL, Szu JI, et al. In vivo detection of cortical optical changes associated with seizure activity with optical coherence tomography. Biomed Opt Express. 2012;3(11):2700-6doi: 10.1364/BOE.3.002700.
Eberle, M. M., Reynolds, C. L., Szu, J. I., Wang, Y., Hansen, A. M., Hsu, M. S., Islam, M. S., Binder, D. K., & Park, B. H. (2012). In vivo detection of cortical optical changes associated with seizure activity with optical coherence tomography. Biomedical optics express, 3(11), 2700-6. https://doi.org/10.1364/BOE.3.002700
Eberle, Melissa M, et al. "In vivo detection of cortical optical changes associated with seizure activity with optical coherence tomography." Biomedical optics express vol. 3,11 (2012): 2700-6. doi: https://doi.org/10.1364/BOE.3.002700
Eberle MM, Reynolds CL, Szu JI, Wang Y, Hansen AM, Hsu MS, Islam MS, Binder DK, Park BH. In vivo detection of cortical optical changes associated with seizure activity with optical coherence tomography. Biomed Opt Express. 2012 Nov 01;3(11):2700-6. doi: 10.1364/BOE.3.002700. Epub 2012 Oct 02. PMID: 23162709; PMCID: PMC3493229.
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Biomed Opt Express. 2012 Nov 01;3(11):2700-6. doi: 10.1364/BOE.3.002700. Epub 2012 Oct 02.

In vivo detection of cortical optical changes associated with seizure activity with optical coherence tomography.

Biomedical optics express

Melissa M Eberle, Carissa L Reynolds, Jenny I Szu, Yan Wang, Anne M Hansen, Mike S Hsu, M Shahidul Islam, Devin K Binder, B Hyle Park

Affiliations

  1. Department of Bioengineering, University of California, Riverside, 900 University Ave., Riverside, CA 92521, USA.

PMID: 23162709 PMCID: PMC3493229 DOI: 10.1364/BOE.3.002700

Abstract

The most common technology for seizure detection is with electroencephalography (EEG), which has low spatial resolution and minimal depth discrimination. Optical techniques using near-infrared (NIR) light have been used to improve upon EEG technology and previous research has suggested that optical changes, specifically changes in near-infrared optical scattering, may precede EEG seizure onset in in vivo models. Optical coherence tomography (OCT) is a high resolution, minimally invasive imaging technique, which can produce depth resolved cross-sectional images. In this study, OCT was used to detect changes in optical properties of cortical tissue in vivo in mice before and during the induction of generalized seizure activity. We demonstrated that a significant decrease (P < 0.001) in backscattered intensity during seizure progression can be detected before the onset of observable manifestations of generalized (stage-5) seizures. These results indicate the feasibility of minimally-invasive optical detection of seizures with OCT.

Keywords: (100.2960) Image analysis; (110.4500) Optical coherence tomography; (170.3880) Medical and biological imaging

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