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Kelly ML, Chernoff J. Mouse models of PAK function. Cell Logist. 2012;2(2):84-88doi: 10.4161/cl.21381.
Kelly, M. L., & Chernoff, J. (2012). Mouse models of PAK function. Cellular logistics, 2(2), 84-88. https://doi.org/10.4161/cl.21381
Kelly, Mollie L, and Chernoff, Jonathan. "Mouse models of PAK function." Cellular logistics vol. 2,2 (2012): 84-88. doi: https://doi.org/10.4161/cl.21381
Kelly ML, Chernoff J. Mouse models of PAK function. Cell Logist. 2012 Apr 01;2(2):84-88. doi: 10.4161/cl.21381. PMID: 23162740; PMCID: PMC3490966.
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Cell Logist. 2012 Apr 01;2(2):84-88. doi: 10.4161/cl.21381.

Mouse models of PAK function.

Cellular logistics

Mollie L Kelly, Jonathan Chernoff

Affiliations

  1. Cancer Biology Program; Fox Chase Cancer Center; Philadelphia, PA USA.

PMID: 23162740 PMCID: PMC3490966 DOI: 10.4161/cl.21381

Abstract

p21-activated kinases are a family of highly conserved protein serine/threonine kinases that are increasingly recognized as playing essential roles in a variety of key signaling processes. Genetic analyses in mice, using constitutive or regulated gene disruption, have provided important new insights into PAK function. In this paper, we review the genetic analysis of all six PAK genes in mice. These data address the singular and redundant functions of the various PAK genes and suggest therapeutic possibilities for small molecule PAK inhibitors or activators.

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