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Fernando H, Martin TA, Douglas-Jones A, et al. Expression of the ERM family members (ezrin, radixin and moesin) in breast cancer. Exp Ther Med. 2010;1(1):153-160doi: 10.3892/etm_00000025.
Fernando, H., Martin, T. A., Douglas-Jones, A., Kynaston, H. G., Mansel, R. E., & Jiang, W. G. (2010). Expression of the ERM family members (ezrin, radixin and moesin) in breast cancer. Experimental and therapeutic medicine, 1(1), 153-160. https://doi.org/10.3892/etm_00000025
Fernando, Herman, et al. "Expression of the ERM family members (ezrin, radixin and moesin) in breast cancer." Experimental and therapeutic medicine vol. 1,1 (2010): 153-160. doi: https://doi.org/10.3892/etm_00000025
Fernando H, Martin TA, Douglas-Jones A, Kynaston HG, Mansel RE, Jiang WG. Expression of the ERM family members (ezrin, radixin and moesin) in breast cancer. Exp Ther Med. 2010 Jan;1(1):153-160. doi: 10.3892/etm_00000025. Epub 2010 Jan 01. PMID: 23136608; PMCID: PMC3490339.
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Exp Ther Med. 2010 Jan;1(1):153-160. doi: 10.3892/etm_00000025. Epub 2010 Jan 01.

Expression of the ERM family members (ezrin, radixin and moesin) in breast cancer.

Experimental and therapeutic medicine

Herman Fernando, Tracey A Martin, Anthony Douglas-Jones, Howard G Kynaston, Robert E Mansel, Wen G Jiang

Affiliations

  1. Metastasis and Angiogenesis Research Group, Wales College of Medicine, Cardiff University, Cardiff, UK.

PMID: 23136608 PMCID: PMC3490339 DOI: 10.3892/etm_00000025

Abstract

The ERM family is composed of the proteins ezrin, moesin and radixin, which are cell structure-related proteins. Despite the detection of viable roles of ERM family proteins, the impact of these molecules in cancer pathogenesis has yet to be investigated. Evidence emerging from clinical and translational studies showed that the ERM family is linked to disease progression in clinical cancers. We aimed to establish the pattern of expression of the ERM proteins and deduce a possible relationship between these molecules and clinical outcome in a cohort of human breast cancers. The expression of the three ERM molecules at the mRNA and protein levels in a cohort of 122 human breast cancers and 32 normal breast tissues were analysed and correlated with pathological and clinical information as well as patient outcome. The three molecules were positively stained in mammary tissues while the staining pattern was lost in the malignant cells. Low levels of moesin and radixin transcripts were seen in tumours from patients with metastasis, local recurrence and in patients who succumbed to the disease (moesin: p=0.039, p=0.037 and p=0.066, respectively, and radixin: p=0.039, p=0.039 and p=0.04, respectively). Ezrin levels were significantly lower in tumour recurrence and in patients who succumbed to the disease (p=0.0001 and p=0.59, respectively). Using the Kaplan-Meier survival analysis, a general trend of higher levels of ERM was observed, with marginal long overall and disease-free survival. In conclusion, an inverse relationship between ERM expression and tumour behaviour of breast cancer patients was noted. However, further work needs to be conducted in other types of cancer in clinical situations to obtain consistent results.

References

  1. Nat Immunol. 2004 Mar;5(3):272-9 - PubMed
  2. J Cell Physiol. 2003 Aug;196(2):362-9 - PubMed
  3. J Cell Sci. 1992 Sep;103 ( Pt 1):131-43 - PubMed
  4. Breast Cancer Res. 2004;6(5):R478-87 - PubMed
  5. J Cell Sci. 1999 Sep;112 Pt 18:3081-90 - PubMed
  6. Cancer Res. 2006 Feb 15;66(4):1982-9 - PubMed
  7. J Cell Biol. 1999 Jun 28;145(7):1497-509 - PubMed
  8. Clin Cancer Res. 2005 Sep 1;11(17):6198-204 - PubMed
  9. J Urol. 2000 Mar;163(3):985-92 - PubMed
  10. Eur Urol. 2005 Nov;48(5):852-7 - PubMed
  11. Proc Natl Acad Sci U S A. 2004 Feb 24;101(8):2601-6 - PubMed
  12. Clin Cancer Res. 2001 Aug;7(8):2555-62 - PubMed
  13. Int J Mol Med. 2004 Nov;14(5):779-86 - PubMed
  14. Nucleic Acids Res. 1997 Jun 15;25(12):2516-21 - PubMed
  15. Nat Med. 2004 Feb;10(2):182-6 - PubMed
  16. J Cell Biol. 1994 Jun;125(6):1371-84 - PubMed
  17. Clin Exp Metastasis. 2007;24(2):69-78 - PubMed
  18. J Cell Sci. 1993 Aug;105 ( Pt 4):1025-43 - PubMed
  19. Ann Surg Oncol. 2006 Jun;13(6):802-8 - PubMed
  20. Int J Cancer. 2003 Sep 20;106(5):752-7 - PubMed
  21. J Clin Pathol. 2007 Feb;60(2):185-9 - PubMed
  22. Curr Opin Cell Biol. 1997 Oct;9(5):659-66 - PubMed
  23. Clin Cancer Res. 2003 Dec 15;9(17):6432-40 - PubMed
  24. J Cell Biol. 1989 Jun;108(6):2369-82 - PubMed

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