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Pongprayoon U, Tuchinda P, Claeson P, et al. Topical antiinflammatory activity of the major lipophilic constituents of the rhizome of Zingiber cassumunar. Part II: Hexane extractives. Phytomedicine. 1997;3(4):323-6doi: 10.1016/S0944-7113(97)80004-9.
Pongprayoon, U., Tuchinda, P., Claeson, P., Sematong, T., Reutrakul, V., & Soontornsaratune, P. (1997). Topical antiinflammatory activity of the major lipophilic constituents of the rhizome of Zingiber cassumunar. Part II: Hexane extractives. Phytomedicine : international journal of phytotherapy and phytopharmacology, 3(4), 323-6. https://doi.org/10.1016/S0944-7113(97)80004-9
Pongprayoon, U, et al. "Topical antiinflammatory activity of the major lipophilic constituents of the rhizome of Zingiber cassumunar. Part II: Hexane extractives." Phytomedicine : international journal of phytotherapy and phytopharmacology vol. 3,4 (1997): 323-6. doi: https://doi.org/10.1016/S0944-7113(97)80004-9
Pongprayoon U, Tuchinda P, Claeson P, Sematong T, Reutrakul V, Soontornsaratune P. Topical antiinflammatory activity of the major lipophilic constituents of the rhizome of Zingiber cassumunar. Part II: Hexane extractives. Phytomedicine. 1997 Feb;3(4):323-6. doi: 10.1016/S0944-7113(97)80004-9. PMID: 23195189.
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Phytomedicine. 1997 Feb;3(4):323-6. doi: 10.1016/S0944-7113(97)80004-9.

Topical antiinflammatory activity of the major lipophilic constituents of the rhizome of Zingiber cassumunar. Part II: Hexane extractives.

Phytomedicine : international journal of phytotherapy and phytopharmacology

U Pongprayoon, P Tuchinda, P Claeson, T Sematong, V Reutrakul, P Soontornsaratune

Affiliations

  1. Pharmaceuticals and Natural Products Department, Thailand Institute of Scientific and Technological Research, Chatuchak, Bangkok, Thailand.

PMID: 23195189 DOI: 10.1016/S0944-7113(97)80004-9

Abstract

A hexane extract of the rhizome of Zingiber cassumunar was found to exhibit topical antiinflammatory activity, when tested in the model of 12-O-tetradecanoylphorbol-13-acetate-induced ear edema in rats (ID(50) = 854 μg/ear). Bioassay-guided fractionation (by MPLC on silica gel) of the hexane extract led to the isolation and identification of (E)-4-(3',4'-dimethoxyphenyl)but-3-enyl acetate (1), cis-3-(3',4'-dimethoxyphenyl)-4-[(E)-3,‴,4‴- dimethoxystyryl]cyclohex-l-ene (2), cis-3-(3',4'-dimethoxyphenyl)-4-[(E)-2‴,4‴,5‴- trimethoxystyryl]cyclohex-1-ene (3), cis-3-(2',4',5'-trimethoxyphenyl)-4-[(E)-2‴,4‴,5‴- trimethoxystyryl]cyclohex-l-ene (4) and (E)-4-(3'-4'-dime-thoxyphenyl)but-3-en-l-ol (5). Compounds 1-5 exerted potent topical antiinflammatory activities with ID(50)-values of 62, 21, 20, 2 and 47μg/ear, respectively. The ID(50) of the reference drug diclofenac was determined to be 61 μg/ear.

Copyright © 1996 Gustav Fischer Verlag. Published by Elsevier GmbH.. All rights reserved.

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