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Mian AI, Laham FR, Cruz AT, et al. Nitric oxide metabolites as biomarkers for influenza-like acute respiratory infections presenting to the emergency room. Open Respir Med J. 2012;6:127-34doi: 10.2174/1874306401206010127.
Mian, A. I., Laham, F. R., Cruz, A. T., Garg, H., Macias, C. G., Caviness, A. C., & Piedra, P. A. (2012). Nitric oxide metabolites as biomarkers for influenza-like acute respiratory infections presenting to the emergency room. The open respiratory medicine journal, 6127-34. https://doi.org/10.2174/1874306401206010127
Mian, Asad I, et al. "Nitric oxide metabolites as biomarkers for influenza-like acute respiratory infections presenting to the emergency room." The open respiratory medicine journal vol. 6 (2012): 127-34. doi: https://doi.org/10.2174/1874306401206010127
Mian AI, Laham FR, Cruz AT, Garg H, Macias CG, Caviness AC, Piedra PA. Nitric oxide metabolites as biomarkers for influenza-like acute respiratory infections presenting to the emergency room. Open Respir Med J. 2012;6:127-34. doi: 10.2174/1874306401206010127. Epub 2012 Nov 14. PMID: 23166571; PMCID: PMC3499797.
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Open Respir Med J. 2012;6:127-34. doi: 10.2174/1874306401206010127. Epub 2012 Nov 14.

Nitric oxide metabolites as biomarkers for influenza-like acute respiratory infections presenting to the emergency room.

The open respiratory medicine journal

Asad I Mian, Federico R Laham, Andrea T Cruz, Harsha Garg, Charles G Macias, A Chantal Caviness, Pedro A Piedra

Affiliations

  1. Dept of Pediatrics, Section of Emergency Medicine, Texas Children's Hospital, Baylor College of Medicine, Houston TX 77030, USA.

PMID: 23166571 PMCID: PMC3499797 DOI: 10.2174/1874306401206010127

Abstract

AIMS: Nitric oxide (NO) is increased in the respiratory tract in pulmonary infections. The aim was to determine whether nasal wash NO metabolites could serve as biomarkers of viral pathogen and disease severity in children with influenza-like illness (ILI) presenting to the emergency department (ED) during the 2009 influenza A H1N1 pandemic.

METHODS: Children ≤18 years old presenting to the ED with ILI were eligible. Nasal wash specimens were tested for NO metabolites, nitrate and nitrite, by HPLC and for respiratory viruses by real-time PCR.

RESULTS: Eighty-nine patients with ILI were prospectively enrolled during Oct-Dec, 2009. In the entire cohort, nasal wash nitrite was low to undetectable (interquartile range [IQR], 0 - 2 μM), while median nitrate was 3.4 μM (IQR 0-8.6). Rhinovirus (23%), respiratory syncytial virus (RSV) (20%), novel H1N1 (19%), and adenovirus (11%) were the most common viruses found. Children with RSV subtype B-associated ILI had higher nitrate compared to all other viruses combined (P=0.002).

CONCLUSION: Concentration of NO-derived nitrate in nasal secretions in children in the ED is suggestive of viral pathogen causative for ILI, and thus might be of clinical utility. Predictive potential of this putative biomarker for ILI needs further evaluation in sicker patients in a prospective manner.

Keywords: Acute respiratory infections; Novel H1N1; RSV.; emergency department; nitrate; pediatrics

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