Circ Res. 2012 Nov 09;111(11):1395-7. doi: 10.1161/CIRCRESAHA.112.281014.
Circulation research
Alan Jiao, Frank J Slack
PMID: 23139285 PMCID: PMC4311873 DOI: 10.1161/CIRCRESAHA.112.281014
Since their discovery not long ago, microRNAs (miRNAs) have been extensively studied in hundreds of laboratories around the world. Initially thought of as merely cytoplasmic repressors of mRNA expression, it has since become more apparent that they also play regulatory roles in the nucleus. A recent study published in Nature introduces novel concepts in both miRNA regulation and function by showing that the let-7 miRNA regulates its own expression.