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Fung JJ, Zeevi A, Demetris AJ, et al. Origin of lymph node-derived lymphocytes in human hepatic allografts. Clin Transpl. 1989;3:316-324
Fung, J. J., Zeevi, A., Demetris, A. J., Starzl, T. E., Markus, B., Chen, K., Marrarri, M., & Duquesnoy, R. J. (1989). Origin of lymph node-derived lymphocytes in human hepatic allografts. Clinical transplants, 3316-324.
Fung, John J, et al. "Origin of lymph node-derived lymphocytes in human hepatic allografts." Clinical transplants vol. 3 (1989): 316-324.
Fung JJ, Zeevi A, Demetris AJ, Starzl TE, Markus B, Chen K, Marrarri M, Duquesnoy RJ. Origin of lymph node-derived lymphocytes in human hepatic allografts. Clin Transpl. 1989;3:316-324. PMID: 23258949; PMCID: PMC3524991.
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Clin Transpl. 1989;3:316-324.

Origin of lymph node-derived lymphocytes in human hepatic allografts.

Clinical transplants

John J Fung, Adriane Zeevi, A Jake Demetris, Thomas E Starzl, Bernd Markus, Kangnian Chen, Marilyn Marrarri, Rene J Duquesnoy

Affiliations

  1. Departments of Surgery and Pathology, University of Pittsburgh, School of Medicine, and the Central Blood Bank of Pittsburgh, Pittsburgh, Pennsylvania, U.S.A.

PMID: 23258949 PMCID: PMC3524991

Abstract

Hepatic allograft-derived lymph nodes were examined in the post-transplant period on order to determine the origin of lymphocytes and structural elements of the lymph node. Histologic assessment and immunohistochemical studies verified that T-cell infiltration of donor lymph nodes by recipient-derived lymphocytes occurred early in the post-transplant period. These T cells bore T-cell activation markers, e.g. TAC receptor and HLA-DR antigens. In addition, functional analysis demonstrated alloreactive T cells in secondary proliferation assays. The pattern of alloreactivity in these assays was dependent upon the phenotypic make-up (and therefore origin) of the lymphocytes within the lymph node. A gradual shift in predominance of donor-derived lymphocytes to recipient-derived lymphocytes occurred, but even late in the post-transplant course the stromal elements and a residium of lymphocytes within the lymph nodes continued to bear donor HLA antigens. The possible role of these "passenger" lymphocytes in allograft immunity is discussed.

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