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Grunes DE, Scordi-Bello I, Suh M, et al. Fulminant hepatic failure attributed to ackee fruit ingestion in a patient with sickle cell trait. Case Rep Transplant. 2012;2012:739238doi: 10.1155/2012/739238.
Grunes, D. E., Scordi-Bello, I., Suh, M., Florman, S., Yao, J., Fiel, M. I., & Thung, S. N. (2012). Fulminant hepatic failure attributed to ackee fruit ingestion in a patient with sickle cell trait. Case reports in transplantation, 2012739238. https://doi.org/10.1155/2012/739238
Grunes, Dianne E, et al. "Fulminant hepatic failure attributed to ackee fruit ingestion in a patient with sickle cell trait." Case reports in transplantation vol. 2012 (2012): 739238. doi: https://doi.org/10.1155/2012/739238
Grunes DE, Scordi-Bello I, Suh M, Florman S, Yao J, Fiel MI, Thung SN. Fulminant hepatic failure attributed to ackee fruit ingestion in a patient with sickle cell trait. Case Rep Transplant. 2012;2012:739238. doi: 10.1155/2012/739238. Epub 2012 Oct 08. PMID: 23259140; PMCID: PMC3504255.
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Case Rep Transplant. 2012;2012:739238. doi: 10.1155/2012/739238. Epub 2012 Oct 08.

Fulminant hepatic failure attributed to ackee fruit ingestion in a patient with sickle cell trait.

Case reports in transplantation

Dianne E Grunes, Irini Scordi-Bello, Matthew Suh, Sander Florman, Jonathan Yao, Maria Isabel Fiel, Swan N Thung

Affiliations

  1. Department of Pathology, Mount Sinai School of Medicine, One Gustave L. Levy Place, P.O. Box 1194, New York, NY 10029, USA.

PMID: 23259140 PMCID: PMC3504255 DOI: 10.1155/2012/739238

Abstract

We report a case of fulminant liver failure resulting in emergent liver transplantation following 3 weeks of nausea, vomiting, and malaise from Jamaican Vomiting Sickness. Jamaican Vomiting Sickness is caused by ingestion of the unripe arils of the Ackee fruit, its seeds and husks. It is characterized by acute gastrointestinal illness and hypoglycemia. In severe cases, central nervous system depression can occur. In previous studies, histologic sections taken from patients with Jamaican Vomiting Sickness have shown hepatotoxicity similar to that seen in Reye syndrome and/or acetaminophen toxicity. We highlight macroscopic and microscopic changes in the liver secondary to hepatoxicity of Ackee fruit versus those caused by a previously unknown sickle cell trait. We discuss the clinical variables and the synergistic hepatotoxic effect of Ackee fruit and ischemic injury from sickled red blood cells, causing massive hepatic necrosis in this patient.

References

  1. Arch Intern Med. 1980 Oct;140(10):1364-6 - PubMed
  2. Clin Chim Acta. 1984 Oct 15;142(3):293-8 - PubMed
  3. Am J Med Sci. 1996 Jun;311(6):292-5 - PubMed
  4. South Med J. 1977 May;70(5):533-8 - PubMed
  5. Gastroenterology. 1986 Jun;90(6):2013-21 - PubMed
  6. Bull Johns Hopkins Hosp. 1953 Feb;92(2):99-127 - PubMed
  7. Ann Emerg Med. 1994 May;23(5):1116-8 - PubMed
  8. N Engl J Med. 1976 Aug 26;295(9):461-7 - PubMed
  9. Nature. 1954 Feb 20;173(4399):356-7 - PubMed
  10. Dis Mon. 2009 Jun;55(6):318-26 - PubMed
  11. Am J Med Sci. 1965 Feb;249:175-85 - PubMed
  12. Clin Toxicol (Phila). 2006;44(3):267-73 - PubMed
  13. Lancet. 1999 Feb 13;353(9152):536-40 - PubMed
  14. Acta Clin Belg. 1990;45(5):311-26 - PubMed

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