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Sridhar BK, Srinatha A, Zaman BB, et al. Development and evaluation of microbial degradation dependent compression coated secnidazole tablets for colonic delivery. Indian J Pharm Sci. 2011;73(6):641-8doi: 10.4103/0250-474X.100238.
Sridhar, B. K., Srinatha, A., Zaman, B. B., & Ragunandan, H. (2011). Development and evaluation of microbial degradation dependent compression coated secnidazole tablets for colonic delivery. Indian journal of pharmaceutical sciences, 73(6), 641-8. https://doi.org/10.4103/0250-474X.100238
Sridhar, B K, et al. "Development and evaluation of microbial degradation dependent compression coated secnidazole tablets for colonic delivery." Indian journal of pharmaceutical sciences vol. 73,6 (2011): 641-8. doi: https://doi.org/10.4103/0250-474X.100238
Sridhar BK, Srinatha A, Zaman BB, Ragunandan H. Development and evaluation of microbial degradation dependent compression coated secnidazole tablets for colonic delivery. Indian J Pharm Sci. 2011 Nov;73(6):641-8. doi: 10.4103/0250-474X.100238. PMID: 23112398; PMCID: PMC3480749.
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Indian J Pharm Sci. 2011 Nov;73(6):641-8. doi: 10.4103/0250-474X.100238.

Development and evaluation of microbial degradation dependent compression coated secnidazole tablets for colonic delivery.

Indian journal of pharmaceutical sciences

B K Sridhar, A Srinatha, B B Zaman, H Ragunandan

Affiliations

  1. Department of Pharmaceutics, National College of Pharmacy, Shimoga-577 201, India.

PMID: 23112398 PMCID: PMC3480749 DOI: 10.4103/0250-474X.100238

Abstract

The present paper describes development of a polysaccharide based compression coated tablets of secnidazole for colon delivery. Core tablet containing secnidazole was compression coated with various proportions of guar gum, xanthan gum and chitosan, either alone or in combinations. Drug release studies were performed in simulated gastric fluid (SGF) for 2 h followed by simulated intestinal fluid (SIF, pH 7.4) up to 24 h. Secnidazole release from the prepared formulations was dependent on the type and concentration of polymer used in the formulation. Tablets coating containing either guar gum or xanthan gum showed ~30-40% drug release in 8 h. Further, in vitro dissolution studies of selected formulations performed in the dissolution media with rat caecal contents showed 54.48±0.24 - 60.42±0.16% of drug release. Formulations with single polymer in coating layer were unsuitable for targeting secnidazole release to colon region. Combination of chitosan with guar gum or xanthan gum exhibited control over secnidazole release.

Keywords: Chitosan; colon targeted drug delivery; compression coating; guar gum; secnidazole; xanthan gum

References

  1. Int J Pharm. 2001 Aug 14;224(1-2):19-38 - PubMed
  2. J Pharm Sci. 1975 Mar;64(3):447-51 - PubMed
  3. Eur J Pharm Sci. 2002 Aug;16(3):185-92 - PubMed
  4. Drug Dev Ind Pharm. 2007 Mar;33(3):255-64 - PubMed
  5. Crit Rev Ther Drug Carrier Syst. 1996;13(3-4):185-223 - PubMed
  6. Eur J Pharm Biopharm. 2007 Aug;67(1):202-10 - PubMed
  7. J Pharm Sci. 1996 Nov;85(11):1255-8 - PubMed
  8. Clin Microbiol Rev. 2001 Jan;14(1):114-28 - PubMed
  9. AAPS PharmSciTech. 2009;10(2):670-7 - PubMed
  10. Int J Pharm. 2002 Apr 2;236(1-2):43-55 - PubMed
  11. J Med Microbiol. 1971 Nov;4(4):451-9 - PubMed

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