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Shanmugasundaram S, Manjunatha N, Vijayan R, et al. Determination and estimation of pharmacokinetic profile of caffeine in form of extract of green tea leaves and its analogy with synthetic form. Indian J Pharm Sci. 2011;73(6):649-55doi: 10.4103/0250-474X.100239.
Shanmugasundaram, S., Manjunatha, N., Vijayan, R., Khatwal, R. B., & Samanta, M. K. (2011). Determination and estimation of pharmacokinetic profile of caffeine in form of extract of green tea leaves and its analogy with synthetic form. Indian journal of pharmaceutical sciences, 73(6), 649-55. https://doi.org/10.4103/0250-474X.100239
Shanmugasundaram, Sangeetha, et al. "Determination and estimation of pharmacokinetic profile of caffeine in form of extract of green tea leaves and its analogy with synthetic form." Indian journal of pharmaceutical sciences vol. 73,6 (2011): 649-55. doi: https://doi.org/10.4103/0250-474X.100239
Shanmugasundaram S, Manjunatha N, Vijayan R, Khatwal RB, Samanta MK. Determination and estimation of pharmacokinetic profile of caffeine in form of extract of green tea leaves and its analogy with synthetic form. Indian J Pharm Sci. 2011 Nov;73(6):649-55. doi: 10.4103/0250-474X.100239. PMID: 23112399; PMCID: PMC3480750.
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Indian J Pharm Sci. 2011 Nov;73(6):649-55. doi: 10.4103/0250-474X.100239.

Determination and estimation of pharmacokinetic profile of caffeine in form of extract of green tea leaves and its analogy with synthetic form.

Indian journal of pharmaceutical sciences

Sangeetha Shanmugasundaram, N Manjunatha, R Vijayan, R B Khatwal, M K Samanta

Affiliations

  1. Department of Pharmaceutical Biotechnology, JSS College of Pharmacy, Ooty-643 001, India.

PMID: 23112399 PMCID: PMC3480750 DOI: 10.4103/0250-474X.100239

Abstract

The aim of the study was to formulate and investigate the pharmacokinetic parameters for the tablets of herbal extract of caffeine with comparison to synthetic formulation. The tablets of the aqueous herbal extract of leaves of Camellia sinensis and synthetic caffeine were formulated by wet granulation technique. The HPLC and HPTLC were applied as analytical tools for estimation of caffeine. The batches of formulation (B1 to B7) were subjected for various pre and post-formulation studies. The pharmacokinetic of the batch B5 was assessed in rabbits, and the results were compared to synthetic batch B7. With the suitable pre and post-formulation results, the B5 showed in vitro release of 90.54% of caffeine at the end of 60 min. The release followed first order kinetics and the plot of Higuchi and Peppas confirms anomalous diffusion as the basic mechanism behind the release. B5 revealed non-significant mean C(max), t(1/2), and AUC of 1.88 μg/ml, 5.52 h and 9.67 μg.h/ml respectively compared to B7. The study highlights; no significant difference in the pharmacological effect of caffeine when administered in the form of extract. The administration of herbal extract can further provide the other health benefits lacked by synthetic caffeine.

Keywords: Camellia sinensis; pharmacokinetics; synthetic caffeine; tablets

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