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Tsuda K. Renin-Angiotensin system and sympathetic neurotransmitter release in the central nervous system of hypertension. Int J Hypertens. 2012;2012:474870doi: 10.1155/2012/474870.
Tsuda, K. (2012). Renin-Angiotensin system and sympathetic neurotransmitter release in the central nervous system of hypertension. International journal of hypertension, 2012474870. https://doi.org/10.1155/2012/474870
Tsuda, Kazushi. "Renin-Angiotensin system and sympathetic neurotransmitter release in the central nervous system of hypertension." International journal of hypertension vol. 2012 (2012): 474870. doi: https://doi.org/10.1155/2012/474870
Tsuda K. Renin-Angiotensin system and sympathetic neurotransmitter release in the central nervous system of hypertension. Int J Hypertens. 2012;2012:474870. doi: 10.1155/2012/474870. Epub 2012 Nov 21. PMID: 23227311; PMCID: PMC3512297.
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Int J Hypertens. 2012;2012:474870. doi: 10.1155/2012/474870. Epub 2012 Nov 21.

Renin-Angiotensin system and sympathetic neurotransmitter release in the central nervous system of hypertension.

International journal of hypertension

Kazushi Tsuda

Affiliations

  1. Cardiovascular and Metabolic Research Center, Kansai University of Health Sciences, Osaka 590-0482, Japan ; Division of Cardiology, Department of Medicine, Wakayama Medical University, Wakayama 641-8509, Japan.

PMID: 23227311 PMCID: PMC3512297 DOI: 10.1155/2012/474870

Abstract

Many Studies suggest that changes in sympathetic nerve activity in the central nervous system might have a crucial role in blood pressure control. The present paper discusses evidence in support of the concept that the brain renin-angiotensin system (RAS) might be linked to sympathetic nerve activity in hypertension. The amount of neurotransmitter release from sympathetic nerve endings can be regulated by presynaptic receptors located on nerve terminals. It has been proposed that alterations in sympathetic nervous activity in the central nervous system of hypertension might be partially due to abnormalities in presynaptic modulation of neurotransmitter release. Recent evidence indicates that all components of the RAS have been identified in the brain. It has been proposed that the brain RAS may actively participate in the modulation of neurotransmitter release and influence the central sympathetic outflow to the periphery. This paper summarizes the results of studies to evaluate the possible relationship between the brain RAS and sympathetic neurotransmitter release in the central nervous system of hypertension.

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