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Senba M, Kawai K, Mori N. Pathogenesis of Metastatic Calcification and Acute Pancreatitis in Adult T-Cell Leukemia under Hypercalcemic State. Leuk Res Treatment. 2011;2012:128617doi: 10.1155/2012/128617.
Senba, M., Kawai, K., & Mori, N. (2012). Pathogenesis of Metastatic Calcification and Acute Pancreatitis in Adult T-Cell Leukemia under Hypercalcemic State. Leukemia research and treatment, 2012128617. https://doi.org/10.1155/2012/128617
Senba, Masachika, et al. "Pathogenesis of Metastatic Calcification and Acute Pancreatitis in Adult T-Cell Leukemia under Hypercalcemic State." Leukemia research and treatment vol. 2012 (2012): 128617. doi: https://doi.org/10.1155/2012/128617
Senba M, Kawai K, Mori N. Pathogenesis of Metastatic Calcification and Acute Pancreatitis in Adult T-Cell Leukemia under Hypercalcemic State. Leuk Res Treatment. 2012;2012:128617. doi: 10.1155/2012/128617. Epub 2011 Dec 01. PMID: 23198151; PMCID: PMC3504271.
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Leuk Res Treatment. 2012;2012:128617. doi: 10.1155/2012/128617. Epub 2011 Dec 01.

Pathogenesis of Metastatic Calcification and Acute Pancreatitis in Adult T-Cell Leukemia under Hypercalcemic State.

Leukemia research and treatment

Masachika Senba, Kioko Kawai, Naoki Mori

Affiliations

  1. Department of Pathology, Institute of Tropical Medicine, Nagasaki University, Nagasaki 852-8523, Japan.

PMID: 23198151 PMCID: PMC3504271 DOI: 10.1155/2012/128617

Abstract

Human T-cell leukemia virus type-1 (HTLV-1) is the causative agent of adult T-cell leukemia (ATL). Hypercalcemia is common in patients with ATL. These patients rarely develop metastatic calcification and acute pancreatitis. The underlying pathogenesis of this condition is osteoclast hyperactivity with associated overproduction of parathyroid hormone-related protein, which results in hypercalcemia in association with bone demineralization. The discovery of the osteoclast differentiation factor receptor activator of nuclear factor-κB ligand (RANKL), its receptor RANK, and its decoy receptor osteoprotegerin (OPG), enhanced our understanding of the mechanisms of ATL-associated hypercalcemia. Macrophage inflammatory protein-1-α, tumor necrosis factor-α, interleukin-1, and interleukin-6 are important molecules that enhance the migration and differentiation of osteoclasts and the associated enhanced production of RANKL for osteoblast formation. In this paper, we focus on metastatic calcification and acute pancreatitis in ATL, highlighting recent advances in the understanding of the molecular role of the RANKL/RANK/OPG system including its interaction with various cytokines and calciotropic hormones in the regulation of osteoclastogenesis for bone resorption in hypercalcemic ATL patients.

References

  1. Proc Jpn Acad Ser B Phys Biol Sci. 2008;84(10):419-38 - PubMed
  2. Nature. 1997 Nov 13;390(6656):175-9 - PubMed
  3. Arch Intern Med. 1988 Apr;148(4):921-5 - PubMed
  4. J Exp Med. 1990 Jul 1;172(1):121-9 - PubMed
  5. Endocrinology. 1993 Jun;132(6):2551-6 - PubMed
  6. Science. 1987 Aug 21;237(4817):893-6 - PubMed
  7. Mol Ther. 2001 Feb;3(2):197-205 - PubMed
  8. J Immunol. 1991 Jan 15;146(2):550-9 - PubMed
  9. J Exp Med. 1990 Sep 1;172(3):759-65 - PubMed
  10. Clin Microbiol Rev. 2010 Jul;23(3):577-89 - PubMed
  11. Jpn J Cancer Res. 1988 Dec;79(12):1264-8 - PubMed
  12. Cell. 1997 Apr 18;89(2):309-19 - PubMed
  13. Lancet. 1986 May 3;1(8488):1031-2 - PubMed
  14. Intern Med. 2001 May;40(5):409-13 - PubMed
  15. Cancer. 1987 Mar 15;59(6):1187-91 - PubMed
  16. Blood. 1998 Jun 15;91(12):4747-51 - PubMed
  17. JAMA. 2004 Jul 28;292(4):490-5 - PubMed
  18. Int J Hematol. 2003 Nov;78(4):304-11 - PubMed
  19. Proc Natl Acad Sci U S A. 1989 Jul;86(14):5620-4 - PubMed
  20. J Clin Endocrinol Metab. 2007 Dec;92(12):4514-21 - PubMed
  21. Clin Interv Aging. 2010 Nov 19;5:345-54 - PubMed
  22. Blood. 2002 Jan 15;99(2):634-40 - PubMed
  23. Cancer. 1982 Oct 15;50(8):1554-62 - PubMed
  24. Leukemia. 1994 Oct;8(10):1708-11 - PubMed
  25. Cancer Sci. 2009 Mar;100(3):490-6 - PubMed
  26. Acta Pathol Jpn. 1985 Mar;35(2):437-48 - PubMed
  27. Science. 1987 Dec 11;238(4833):1568-70 - PubMed
  28. Ann N Y Acad Sci. 2010 Mar;1192:117-23 - PubMed
  29. Blood. 1977 Sep;50(3):481-92 - PubMed
  30. Domest Anim Endocrinol. 1988 Jan;5(1):1-21 - PubMed
  31. Jpn J Cancer Res. 1993 Apr;84(4):425-30 - PubMed
  32. Am J Surg. 1987 Nov;154(5):487-9 - PubMed
  33. Nat Rev Cancer. 2007 Apr;7(4):270-80 - PubMed
  34. Br J Haematol. 1998 Jun;101(4):688-93 - PubMed
  35. J Neurol Sci. 2005 Oct 15;237(1-2):53-9 - PubMed
  36. Lancet. 1985 Aug 24;2(8452):407-10 - PubMed
  37. Am J Gastroenterol. 1990 Sep;85(9):1202-3 - PubMed
  38. Arch Surg. 1968 Aug;97(2):267-74 - PubMed
  39. Int J Hematol. 1997 Oct;66(3):257-78 - PubMed
  40. Eur J Haematol. 1992 May;48(5):278-9 - PubMed
  41. J Virol. 2003 Sep;77(17):9716-22 - PubMed
  42. Cell. 1998 Apr 17;93(2):165-76 - PubMed
  43. J Clin Invest. 1987 Sep;80(3):911-6 - PubMed
  44. Science. 1987 Dec 11;238(4833):1566-8 - PubMed
  45. Blood. 2001 Sep 1;98(5):1506-11 - PubMed
  46. Proc Natl Acad Sci U S A. 1984 Oct;81(19):6207-11 - PubMed
  47. Virology. 1984 Feb;133(1):238-41 - PubMed
  48. Zentralbl Pathol. 1991;137(4):341-5 - PubMed
  49. Exp Mol Med. 2002 Nov 30;34(5):347-52 - PubMed
  50. Lancet. 1991 Jun 15;337(8755):1489 - PubMed
  51. J Clin Invest. 1988 Feb;81(2):596-600 - PubMed
  52. Leuk Lymphoma. 1994 Aug;14(5-6):395-400 - PubMed
  53. Lancet Infect Dis. 2007 Apr;7(4):266-81 - PubMed
  54. J Gastroenterol Hepatol. 1996 Feb;11(2):180-2 - PubMed
  55. J Neurovirol. 2002 Feb;8(1):53-7 - PubMed
  56. Proc Natl Acad Sci U S A. 1999 Mar 30;96(7):3540-5 - PubMed
  57. Curr Rev Musculoskelet Med. 2009 Mar;2(1):56-64 - PubMed
  58. J Virol. 2003 May;77(9):5286-94 - PubMed
  59. Proc Natl Acad Sci U S A. 1980 Dec;77(12):7415-9 - PubMed
  60. J Hum Genet. 2001;46(5):267-72 - PubMed
  61. Ann N Y Acad Sci. 2006 Apr;1068:100-9 - PubMed
  62. Vet Pathol. 2009 Sep;46(5):1003-14 - PubMed
  63. Gastroenterology. 1977 Aug;73(2):221-5 - PubMed
  64. Oncogene. 2005 Sep 5;24(39):6058-68 - PubMed
  65. J Comput Assist Tomogr. 1996 Jan-Feb;20(1):38-41 - PubMed
  66. Bone. 2001 Feb;28(2):208-14 - PubMed
  67. Am J Med. 1991 Feb;90(2):251-4 - PubMed
  68. Proc Natl Acad Sci U S A. 1981 Oct;78(10):6476-80 - PubMed
  69. J Biol Chem. 1987 May 25;262(15):7151-6 - PubMed
  70. Leuk Res. 2002 Jun;26(6):561-7 - PubMed
  71. Pathol Int. 1998 Apr;48(4):313-8 - PubMed
  72. J Bone Miner Res. 2002 Jul;17(7):1200-10 - PubMed
  73. Lab Invest. 2004 Feb;84(2):263-6 - PubMed
  74. Oncogene. 2005 Sep 5;24(39):6005-15 - PubMed
  75. Trends Microbiol. 2004 Jul;12(7):346-52 - PubMed
  76. Arch Pathol (Chic). 1947 Feb;43(2):177-230 - PubMed
  77. Acta Neuropathol. 2000 Sep;100(3):245-52 - PubMed
  78. J Virol. 1993 Oct;67(10):6087-95 - PubMed
  79. N Engl J Med. 1988 Sep 1;319(9):556-63 - PubMed
  80. J Clin Invest. 1987 Dec;80(6):1803-7 - PubMed
  81. Int J Biochem Cell Biol. 2007;39(6):1077-81 - PubMed
  82. Retrovirology. 2010 Jul 23;7:61 - PubMed
  83. J Exp Med. 1999 Dec 20;190(12):1741-54 - PubMed
  84. J Gastroenterol Hepatol. 1996 Feb;11(2):193-5 - PubMed
  85. Am J Respir Crit Care Med. 2002 Jun 15;165(12):1654-69 - PubMed
  86. J Bone Miner Res. 2004 Sep;19(9):1411-9 - PubMed
  87. Oncogene. 2003 Aug 11;22(33):5131-40 - PubMed
  88. Cancer Res. 2005 Jun 1;65(11):4467-70 - PubMed
  89. Endocr Rev. 2000 Apr;21(2):115-37 - PubMed
  90. Brain. 2003 Jan;126(Pt 1):20-31 - PubMed
  91. Cancer. 1997 Oct 15;80(8 Suppl):1557-63 - PubMed
  92. J Bone Miner Res. 2004 Jul;19(7):1105-11 - PubMed
  93. Immunol Today. 2000 Oct;21(10):495-502 - PubMed
  94. Biochem Biophys Res Commun. 2000 Jan 27;267(3):943-6 - PubMed
  95. Cancer Cell Int. 2009 Sep 12;9:26 - PubMed
  96. Blood. 1988 Jan;71(1):263-6 - PubMed
  97. Periodontol 2000. 2010 Oct;54(1):235-46 - PubMed
  98. Proc Natl Acad Sci U S A. 1982 Mar;79(6):2031-5 - PubMed
  99. Endocrinology. 1999 Feb;140(2):925-32 - PubMed
  100. Am J Pathol. 2001 Jun;158(6):2219-28 - PubMed
  101. Leuk Lymphoma. 2010 Apr;51(4):702-14 - PubMed

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