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Inokuchi R, Matsumoto A, Azihara R, et al. Hypertriglyceridemia as a possible cause of coma: a case report. J Med Case Rep. 2012;6:412doi: 10.1186/1752-1947-6-412.
Inokuchi, R., Matsumoto, A., Azihara, R., Sato, H., Kumada, Y., Yokoyama, H., Okada, M., Ishida, T., Nakamura, K., Nakajima, S., Yahagi, N., & Shinohara, K. (2012). Hypertriglyceridemia as a possible cause of coma: a case report. Journal of medical case reports, 6412. https://doi.org/10.1186/1752-1947-6-412
Inokuchi, Ryota, et al. "Hypertriglyceridemia as a possible cause of coma: a case report." Journal of medical case reports vol. 6 (2012): 412. doi: https://doi.org/10.1186/1752-1947-6-412
Inokuchi R, Matsumoto A, Azihara R, Sato H, Kumada Y, Yokoyama H, Okada M, Ishida T, Nakamura K, Nakajima S, Yahagi N, Shinohara K. Hypertriglyceridemia as a possible cause of coma: a case report. J Med Case Rep. 2012 Nov 30;6:412. doi: 10.1186/1752-1947-6-412. PMID: 23198781; PMCID: PMC3520695.
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J Med Case Rep. 2012 Nov 30;6:412. doi: 10.1186/1752-1947-6-412.

Hypertriglyceridemia as a possible cause of coma: a case report.

Journal of medical case reports

Ryota Inokuchi, Akinori Matsumoto, Ryuta Azihara, Hajime Sato, Yoshibumi Kumada, Hideyuki Yokoyama, Megumi Okada, Tokiya Ishida, Kensuke Nakamura, Susumu Nakajima, Naoki Yahagi, Kazuaki Shinohara

Affiliations

  1. Department of Emergency and Critical Care Medicine, Ohta Nishinouchi Hospital, 2-5-20 Nishinouchi, Koriyama, Fukushima, 963-8558, Japan. [email protected].

PMID: 23198781 PMCID: PMC3520695 DOI: 10.1186/1752-1947-6-412

Abstract

INTRODUCTION: Many studies suggest that elevated triglyceride levels are associated with increased long-term risk of stroke, including transient ischemic attacks. In addition, elevated triglyceride levels independently contribute to plasma viscosity and decreased blood flow. However, no consensus has been reached regarding the significance of hypertriglyceridemia as an independent risk factor for ischemic stroke.

CASE PRESENTATION: We report the case of a patient admitted to our hospital for sudden onset of coma. Laboratory test results revealed he had high blood glucose (28.2mmol/L), high glycated hemoglobin (11.4 percent), considerably high serum triglyceride levels (171.5mmol/L; type V hyperlipoproteinemia), and high plasma viscosity (1.90mPa/s) with normal β-hydroxybutyric acid levels. His triglyceride levels decreased after administering intravenous fluids. Our patient's consciousness level improved gradually over three days. All serum lipid levels decreased seven days after admission.

CONCLUSIONS: The findings in our patient's case are likely explained by triglyceride-mediated hyperviscosity causing a transient ischemic attack. In the present report we suggest that when several tests do not reveal the cause of stroke-like symptoms, measurement of plasma viscosity may be informative.

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