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Hanes PJ, Krishna R. Characteristics of inflammation common to both diabetes and periodontitis: are predictive diagnosis and targeted preventive measures possible?. EPMA J. 2010;1(1):101-16doi: 10.1007/s13167-010-0016-3.
Hanes, P. J., & Krishna, R. (2010). Characteristics of inflammation common to both diabetes and periodontitis: are predictive diagnosis and targeted preventive measures possible?. The EPMA journal, 1(1), 101-16. https://doi.org/10.1007/s13167-010-0016-3
Hanes, Philip J, and Krishna, Ranjitha. "Characteristics of inflammation common to both diabetes and periodontitis: are predictive diagnosis and targeted preventive measures possible?." The EPMA journal vol. 1,1 (2010): 101-16. doi: https://doi.org/10.1007/s13167-010-0016-3
Hanes PJ, Krishna R. Characteristics of inflammation common to both diabetes and periodontitis: are predictive diagnosis and targeted preventive measures possible?. EPMA J. 2010 Mar;1(1):101-16. doi: 10.1007/s13167-010-0016-3. Epub 2010 Apr 03. PMID: 23199045; PMCID: PMC3405308.
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EPMA J. 2010 Mar;1(1):101-16. doi: 10.1007/s13167-010-0016-3. Epub 2010 Apr 03.

Characteristics of inflammation common to both diabetes and periodontitis: are predictive diagnosis and targeted preventive measures possible?.

The EPMA journal

Philip J Hanes, Ranjitha Krishna

Affiliations

  1. Department of Periodontics, Medical College of Georgia School of Dentistry, Augusta, GA 30912 USA.

PMID: 23199045 PMCID: PMC3405308 DOI: 10.1007/s13167-010-0016-3

Abstract

Diabetes and periodontitis are chronic inflammatory disorders that contribute to each others' severity and worsen each others' prognosis. Studies have shown that patients with diabetes are at increased risk of developing periodontitis, and that diabetics with untreated periodontitis have more difficulty controlling serum glucose. Periodontal treatment that reduces gingival inflammation aids in the control of hyperglycemia. Periodontitis is accompanied by gingival bleeding and the production of an inflammatory exudate termed gingival crevicular fluid (GCF) that arises from the inflamed gingival tissues surrounding the teeth. GCF contains byproducts of connective tissue degradation, enzymes from host and bacterial cells, cytokines and other inflammatory mediators, and has been studied for screening blood glucose and for biomarkers of both diabetes and periodontitis. This review focuses on the inter-relationship between diabetes and periodontitis and the biomarkers common to both these diseases that may enable earlier detection, targeted preventive measures and individualized therapeutic intervention of these chronic conditions.

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