Display options
Cite
Hilscher M, Hernandez-Gea V, Friedman SL. Autophagy and mesenchymal cell fibrogenesis. Biochim Biophys Acta. 2012;1831(7):972-8doi: 10.1016/j.bbadis.2012.11.001.
Hilscher, M., Hernandez-Gea, V., & Friedman, S. L. (2012). Autophagy and mesenchymal cell fibrogenesis. Biochimica et biophysica acta, 1831(7), 972-8. https://doi.org/10.1016/j.bbadis.2012.11.001
Hilscher, Moira, et al. "Autophagy and mesenchymal cell fibrogenesis." Biochimica et biophysica acta vol. 1831,7 (2012): 972-8. doi: https://doi.org/10.1016/j.bbadis.2012.11.001
Hilscher M, Hernandez-Gea V, Friedman SL. Autophagy and mesenchymal cell fibrogenesis. Biochim Biophys Acta. 2012 Jul;1831(7):972-8. doi: 10.1016/j.bbadis.2012.11.001. Epub 2012 Nov 09. PMID: 23142802; PMCID: PMC3608743.
Copy Download .nbib Format: NLM
Share it on

Biochim Biophys Acta. 2012 Jul;1831(7):972-8. doi: 10.1016/j.bbadis.2012.11.001. Epub 2012 Nov 09.

Autophagy and mesenchymal cell fibrogenesis.

Biochimica et biophysica acta

Moira Hilscher, Virginia Hernandez-Gea, Scott L Friedman

Affiliations

  1. Division of Liver Diseases, Mount Sinai School of Medicine, New York, NY, USA.

PMID: 23142802 PMCID: PMC3608743 DOI: 10.1016/j.bbadis.2012.11.001

Abstract

Autophagy is a catabolic pathway essential for cellular energy homeostasis that involves the self-degradation of intracellular components in lysosomes. This process has been implicated in the pathophysiology of many human disorders, including infection, cancer, and fibrosis. Autophagy is also recognized as a mediator of survival and proliferation, and multiple pathways induce autophagy under conditions of cellular stress, including nutrient and energy depletion. High autophagic activity has been detected in fibrogenic cells from several tissues; however the role of autophagy in fibrogenesis and mesenchymal cells varies greatly in different tissues and settings, with contributions uncovered to energy metabolism and collagen turnover by fibrogenic cells. Because several chemical modulators of autophagy have already been identified, autophagy regulation constitutes a potential target for antifibrotic therapy. This article is part of a Special Issue entitled: Fibrosis: Translation of basic research to human disease.

Copyright © 2012 Elsevier B.V. All rights reserved.

References

  1. J Biol Chem. 2006 Mar 31;281(13):8518-27 - PubMed
  2. Cancer Res. 2006 Jul 1;66(13):6861-70 - PubMed
  3. Carcinogenesis. 2011 Jul;32(7):964-72 - PubMed
  4. Chem Soc Rev. 2012 Apr 21;41(8):3245-63 - PubMed
  5. Nat Cell Biol. 2010 Sep;12(9):831-5 - PubMed
  6. Annu Rev Genet. 2009;43:67-93 - PubMed
  7. Arthritis Res Ther. 2010;12(1):R19 - PubMed
  8. J Histochem Cytochem. 2006 Jan;54(1):85-96 - PubMed
  9. EMBO J. 2010 Jan 6;29(1):27-40 - PubMed
  10. Physiol Rev. 2003 Jul;83(3):731-801 - PubMed
  11. PLoS One. 2009 Sep 22;4(9):e7124 - PubMed
  12. Mol Cell. 2008 Jun 20;30(6):678-88 - PubMed
  13. Cell. 2010 May 14;141(4):656-67 - PubMed
  14. J Biol Chem. 2000 Jan 14;275(2):992-8 - PubMed
  15. J Biol Chem. 2006 Nov 17;281(46):34870-9 - PubMed
  16. Gastroenterology. 2012 Apr;142(4):938-46 - PubMed
  17. Am J Pathol. 2010 Aug;177(2):632-43 - PubMed
  18. J Pathol. 2010 Jun;221(2):117-24 - PubMed
  19. J Pathol. 2008 Jan;214(2):199-210 - PubMed
  20. Proc Natl Acad Sci U S A. 2011 Mar 8;108(10):4123-8 - PubMed
  21. Biochim Biophys Acta. 2011 Jan;1812(1):23-31 - PubMed
  22. Nat Cell Biol. 2010 Aug;12(8):747-57 - PubMed
  23. PLoS One. 2011;6(8):e23367 - PubMed
  24. Cell. 1997 Oct 17;91(2):231-41 - PubMed
  25. Arthritis Res Ther. 2012 Mar 14;14(2):R62 - PubMed
  26. Cell Cycle. 2011 Jun 15;10(12):2021-34 - PubMed
  27. Cell Res. 2007 Aug;17(8):666-81 - PubMed
  28. Nat Rev Mol Cell Biol. 2009 Jul;10(7):458-67 - PubMed
  29. Eur J Pharmacol. 2009 Dec 25;625(1-3):220-33 - PubMed
  30. J Biol Chem. 2009 Mar 6;284(10):6322-8 - PubMed
  31. Sci Signal. 2012 Jul 03;5(231):pe29 - PubMed
  32. Nat Chem Biol. 2008 May;4(5):295-305 - PubMed
  33. Autophagy. 2008 Feb;4(2):151-75 - PubMed
  34. J Biol Chem. 2007 Aug 17;282(33):24131-45 - PubMed
  35. Autophagy. 2005 Apr;1(1):1-10 - PubMed
  36. Methods Mol Biol. 2007;369:309-29 - PubMed
  37. Autophagy. 2007 Sep-Oct;3(5):452-60 - PubMed
  38. Mol Biol Cell. 2004 Mar;15(3):1101-11 - PubMed
  39. Proc Natl Acad Sci U S A. 1982 Mar;79(6):1889-92 - PubMed
  40. Nat Rev Mol Cell Biol. 2003 Jul;4(7):517-29 - PubMed
  41. Annu Rev Pathol. 2012;7:423-67 - PubMed
  42. Science. 2012 Apr 27;336(6080):477-81 - PubMed
  43. Cardiovasc Res. 2000 May;46(2):250-6 - PubMed
  44. EMBO Rep. 2009 Mar;10(3):285-92 - PubMed
  45. J Clin Invest. 2007 Mar;117(3):524-9 - PubMed
  46. Nat Cell Biol. 2007 Oct;9(10):1102-9 - PubMed
  47. Cell Cycle. 2011 Jul 1;10(13):2140-50 - PubMed
  48. EMBO J. 2010 Feb 3;29(3):619-31 - PubMed
  49. Science. 2012 Apr 27;336(6080):474-7 - PubMed
  50. J Biol Chem. 2012 Apr 6;287(15):11677-88 - PubMed
  51. Mol Cell Biol. 2001 Jul;21(13):4347-68 - PubMed
  52. J Biol Chem. 2010 Nov 26;285(48):37909-19 - PubMed
  53. Physiol Rev. 2010 Oct;90(4):1383-435 - PubMed
  54. Eur J Biochem. 1997 Jan 15;243(1-2):240-6 - PubMed
  55. Mol Aspects Med. 2006 Oct-Dec;27(5-6):411-25 - PubMed
  56. EMBO J. 2000 Nov 1;19(21):5720-8 - PubMed
  57. J Invest Dermatol. 2009 Oct;129(10):2333-5 - PubMed
  58. Cell Struct Funct. 1998 Feb;23(1):33-42 - PubMed
  59. Nat Chem Biol. 2011 Jan;7(1):9-17 - PubMed
  60. J Hepatol. 2011 Dec;55(6):1353-60 - PubMed
  61. Autophagy. 2005 Jul;1(2):84-91 - PubMed
  62. Nature. 2002 May 16;417(6886):292-5 - PubMed
  63. J Cell Biol. 2000 Oct 16;151(2):263-76 - PubMed
  64. Cancer Res. 2007 Jun 15;67(12):5840-50 - PubMed
  65. J Biol Chem. 2009 Mar 20;284(12):8023-32 - PubMed
  66. Am J Physiol Renal Physiol. 2012 Jul 1;303(1):F83-91 - PubMed
  67. Mol Biol Cell. 2009 Apr;20(7):1981-91 - PubMed
  68. Proc Natl Acad Sci U S A. 2012 Feb 7;109(6):2003-8 - PubMed
  69. Life Sci. 2005 Sep 30;77(20):2594-602 - PubMed

Publication Types

Grant support