Display options
Cite
Devata S, Kim EJ. Neoadjuvant chemotherapy with capecitabine and temozolomide for unresectable pancreatic neuroendocrine tumor. Case Rep Oncol. 2012;5(3):622-6doi: 10.1159/000345369.
Devata, S., & Kim, E. J. (2012). Neoadjuvant chemotherapy with capecitabine and temozolomide for unresectable pancreatic neuroendocrine tumor. Case reports in oncology, 5(3), 622-6. https://doi.org/10.1159/000345369
Devata, Sumana, and Kim, Edward J. "Neoadjuvant chemotherapy with capecitabine and temozolomide for unresectable pancreatic neuroendocrine tumor." Case reports in oncology vol. 5,3 (2012): 622-6. doi: https://doi.org/10.1159/000345369
Devata S, Kim EJ. Neoadjuvant chemotherapy with capecitabine and temozolomide for unresectable pancreatic neuroendocrine tumor. Case Rep Oncol. 2012 Sep;5(3):622-6. doi: 10.1159/000345369. Epub 2012 Sep 20. PMID: 23275776; PMCID: PMC3531952.
Copy Download .nbib Format: NLM
Share it on

Case Rep Oncol. 2012 Sep;5(3):622-6. doi: 10.1159/000345369. Epub 2012 Sep 20.

Neoadjuvant chemotherapy with capecitabine and temozolomide for unresectable pancreatic neuroendocrine tumor.

Case reports in oncology

Sumana Devata, Edward J Kim

Affiliations

  1. Department of Internal Medicine, University of Michigan Medical Center, Ann Arbor, Mich., USA.

PMID: 23275776 PMCID: PMC3531952 DOI: 10.1159/000345369

Abstract

Pancreatic neuroendocrine tumors (PNETs) are relatively rare tumors that arise in the endocrine cells of the pancreas. Historically, somatostatin analogues have been used in this disease primarily for symptom control and, to a limited extent, disease stability. More recently, sunitinib and everolimus have been approved for advanced stage PNETs based on a survival benefit. However, both agents have a <10% actual response rate and cause nontrivial side effect profiles that limit duration of therapy. In locally advanced disease, there is a paucity of data to support an optimal neoadjuvant approach with the expectation of down-staging to allow for curative resection. We describe in this case a young woman who was successfully down-staged using a chemotherapy regimen of capecitabine and temozolomide with minimal toxicity.

Keywords: Capecitabine; Pancreatic neuroendocrine tumor; Temozolomide

References

  1. N Engl J Med. 2011 Feb 10;364(6):514-23 - PubMed
  2. J Natl Compr Canc Netw. 2012 Jun 1;10(6):777-83 - PubMed
  3. Ann Oncol. 2008 Oct;19(10):1727-33 - PubMed
  4. Ann Oncol. 2012 Oct;23 Suppl 7:vii124-30 - PubMed
  5. J Clin Oncol. 2009 Oct 1;27(28):4656-63 - PubMed
  6. N Engl J Med. 2011 Feb 10;364(6):501-13 - PubMed
  7. Cancer. 2011 Jan 15;117(2):268-75 - PubMed
  8. J Clin Oncol. 2008 Jun 20;26(18):3063-72 - PubMed

Publication Types