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Ha BK, Kim BG, Kim DH, et al. Relationships between Brachial-Ankle Pulse Wave Velocity and Peripheral Neuropathy in Type 2 Diabetes. Diabetes Metab J. 2012;36(6):443-51doi: 10.4093/dmj.2012.36.6.443.
Ha, B. K., Kim, B. G., Kim, D. H., Lee, S. I., Jung, S. M., Park, J. Y., Lee, C. W., Kim, S. S., Kim, B. H., & Kim, I. J. (2012). Relationships between Brachial-Ankle Pulse Wave Velocity and Peripheral Neuropathy in Type 2 Diabetes. Diabetes & metabolism journal, 36(6), 443-51. https://doi.org/10.4093/dmj.2012.36.6.443
Ha, Byung Kil, et al. "Relationships between Brachial-Ankle Pulse Wave Velocity and Peripheral Neuropathy in Type 2 Diabetes." Diabetes & metabolism journal vol. 36,6 (2012): 443-51. doi: https://doi.org/10.4093/dmj.2012.36.6.443
Ha BK, Kim BG, Kim DH, Lee SI, Jung SM, Park JY, Lee CW, Kim SS, Kim BH, Kim IJ. Relationships between Brachial-Ankle Pulse Wave Velocity and Peripheral Neuropathy in Type 2 Diabetes. Diabetes Metab J. 2012 Dec;36(6):443-51. doi: 10.4093/dmj.2012.36.6.443. Epub 2012 Dec 12. PMID: 23275938; PMCID: PMC3530715.
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Diabetes Metab J. 2012 Dec;36(6):443-51. doi: 10.4093/dmj.2012.36.6.443. Epub 2012 Dec 12.

Relationships between Brachial-Ankle Pulse Wave Velocity and Peripheral Neuropathy in Type 2 Diabetes.

Diabetes & metabolism journal

Byung Kil Ha, Bong Gun Kim, Dong Hyun Kim, Soon Il Lee, Soon Myung Jung, Ja Young Park, Chang Won Lee, Sang Soo Kim, Bo Hyun Kim, In Ju Kim

Affiliations

  1. Department of Internal Medicine, Busan St. Mary's Medical Center, Busan, Korea.

PMID: 23275938 PMCID: PMC3530715 DOI: 10.4093/dmj.2012.36.6.443

Abstract

BACKGROUND: Brachial-ankle pulse wave velocity (baPWV) is known to be a good surrogate marker of clinical atherosclerosis. Atherosclerosis is a major predictor for developing neuropathy. The goal of this study was to determine the relationship between baPWV and diabetic peripheral neuropathy (DPN) in patients with type 2 diabetes.

METHODS: A retrospective cross-sectional study was conducted involving 692 patients with type 2 diabetes. The correlation between increased baPWV and DPN, neurological symptoms, and neurological assessment was analyzed. DPN was examined using the total symptom score (TSS), ankle reflexes, the vibration test, and the 10-g monofilament test. DPN was defined as TSS ≥2 and an abnormal neurological assessment. Data were expressed as means±standard deviation for normally distributed data and as median (interquartile range) for non-normally distributed data. Independent t-tests or chi-square tests were used to make comparisons between groups, and a multiple logistic regression test was used to evaluate independent predictors of DPN. The Mantel-Haenszel chi-square test was used to adjust for age.

RESULTS: Patients with DPN had higher baPWV and systolic blood pressure, and were more likely to be older and female, when compared to the control group. According to univariate analysis of risk factors for DPN, the odds ratio of the baPWV ≥1,600 cm/sec was 1.611 (95% confidence interval [CI], 1.072 to 2.422; P=0.021) and the odds ratio in female was 1.816 (95% CI, 1.195 to 2.760; P=0.005).

CONCLUSION: Increased baPWV was significantly correlated with peripheral neuropathy in patients with type 2 diabetes.

Keywords: Brachial-ankle pulse wave velocity; Diabetes mellitus, type 2; Diabetic peripheral neuropathy

References

  1. Diabetes Care. 2002 Nov;25(11):2010-5 - PubMed
  2. N Engl J Med. 1997 Apr 3;336(14):973-9 - PubMed
  3. Neurology. 1999 Nov 10;53(8):1614-5 - PubMed
  4. Cleve Clin J Med. 2009 May;76(5):297-305 - PubMed
  5. Stroke. 2001 Feb;32(2):454-60 - PubMed
  6. Diabetes Care. 2002 Nov;25(11):2048-52 - PubMed
  7. Free Radic Res. 1999 Sep;31(3):171-9 - PubMed
  8. Diabetes Res Clin Pract. 1995 Jul;29(1):37-42 - PubMed
  9. Diabet Med. 1998 Jun;15(6):508-14 - PubMed
  10. Hypertension. 1995 Jul;26(1):2-9 - PubMed
  11. J Hypertens Suppl. 1999 Dec;17(5):S41-4 - PubMed
  12. Hypertens Res. 2003 Oct;26(10):807-13 - PubMed
  13. Diabetes. 2003 May;52(5):1210-4 - PubMed
  14. Diabetes Res Clin Pract. 1991 Aug;13(1-2):63-7 - PubMed
  15. Hypertens Res. 2002 May;25(3):351-8 - PubMed
  16. Diabetologia. 2000 Aug;43(8):957-73 - PubMed
  17. JAMA. 1999 May 12;281(18):1722-7 - PubMed
  18. Diabetes Care. 2004 Jun;27(6):1458-86 - PubMed
  19. Diabetes Care. 1997 Mar;20(3):369-73 - PubMed
  20. Diabetes Care. 1994 Jun;17(6):557-60 - PubMed
  21. Clin Ther. 2005 Aug;27(8):1278-94 - PubMed
  22. Diabetologia. 1995 Dec;38(12):1425-33 - PubMed
  23. Pain. 1988 Jul;34(1):1-10 - PubMed
  24. Med Clin North Am. 2003 May;87(3):697-724 - PubMed
  25. Diabetes Care. 2003 May;26(5):1553-79 - PubMed
  26. Diabetes Care. 2003 Jan;26(1):199-205 - PubMed
  27. Diabet Med. 1999 Oct;16(10):801-12 - PubMed
  28. Diabetes Care. 1994 Nov;17(11):1281-9 - PubMed
  29. Diabetes Care. 2010 Oct;33(10):2285-93 - PubMed
  30. Hypertension. 2001 May;37(5):1236-41 - PubMed
  31. Diabetes Res Clin Pract. 2009 Jul;85(1):30-4 - PubMed
  32. Am J Hypertens. 2002 Dec;15(12):1101-8 - PubMed
  33. Ann Neurol. 1998 Jul;44(1):47-59 - PubMed
  34. Diabetes Care. 2001 Dec;24(12):2107-14 - PubMed
  35. J Atheroscler Thromb. 2003;10(4):253-8 - PubMed

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