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Alghasham A, Settin AA, Ali A, et al. Association of MTHFR C677T and A1298C gene polymorphisms with hypertension. Int J Health Sci (Qassim). 2012;6(1):3-11doi: 10.12816/0005968.
Alghasham, A., Settin, A. A., Ali, A., Dowaidar, M., & Ismail, H. (2012). Association of MTHFR C677T and A1298C gene polymorphisms with hypertension. International journal of health sciences, 6(1), 3-11. https://doi.org/10.12816/0005968
Alghasham, Abdullah, et al. "Association of MTHFR C677T and A1298C gene polymorphisms with hypertension." International journal of health sciences vol. 6,1 (2012): 3-11. doi: https://doi.org/10.12816/0005968
Alghasham A, Settin AA, Ali A, Dowaidar M, Ismail H. Association of MTHFR C677T and A1298C gene polymorphisms with hypertension. Int J Health Sci (Qassim). 2012 Jan;6(1):3-11. doi: 10.12816/0005968. PMID: 23267299; PMCID: PMC3523778.
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Int J Health Sci (Qassim). 2012 Jan;6(1):3-11. doi: 10.12816/0005968.

Association of MTHFR C677T and A1298C gene polymorphisms with hypertension.

International journal of health sciences

Abdullah Alghasham, Ahmad A Settin, Ahmad Ali, Moataz Dowaidar, Hisham Ismail

Affiliations

  1. Molecular Biology Research Center, College of Medicine, Qassim University, Saudi Arabia ; Department of Pharmacology, College of Medicine, Qassim University, Saudi Arabia.

PMID: 23267299 PMCID: PMC3523778 DOI: 10.12816/0005968

Abstract

OBJECTIVES: To check for the association of genetic polymorphisms related to the methylenetetrahydrofolate reductase (MTHFR) gene namely C677T and A1298C with hypertension in Saudi affected subjects from Qassim region.

SUBJECTS AND METHODS: Participants included 123 Saudi hypertensive cases (83 males and 40 females) in addition to 250 (142 males and 108 females) unrelated healthy controls from the same locality. Their age mean ±SD was 50.93 ± 15.43 years. For all subjects, DNA was extracted followed by real-time PCR amplifications for characterization of genotypes and alleles related to MTHFR C677T and A1298C gene polymorphisms

RESULTS: Total cases showed significantly higher carriage rate for the mutant allele 677T compared to controls (40.7% vs. 26%, OR=1.9, 95% CI= 1.2-3.1) with a lower frequency of the wild type 677CC genotype (59.3% vs. 74%, p=0.004). The same was observed among cases-subgroups of hypertension associated with obesity with a notably higher odds ratio (OR=2.6, 95% CI=1.3-5.01, p=0.004). Total cases showed also significantly higher frequency of mutant 1298 C allele carriage rate compared to controls (59.3% vs. 42.4%, OR=1.98, 95% CI= 1.3-3.1) with a lower frequency of the normal AA genotype (40.7% vs. 57.6%, p=0.003). The same was observed among cases-subgroups of hypertension associated with both diabetes and obesity and among cases of hypertension with obesity, also with higher odds ratio (OR=2.6 and 2.2 respectively).

CONCLUSION: This work showed that genetic polymorphisms related to the MTHFR gene are associated with the risk of hypertension particularly when accompanied with obesity and diabetes among Saudi subjects.

Keywords: Genetic polymorphisms; Methylenetetrahydrofolate reductase; Saudi; hypertension

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