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Baroody FM, Naclerio RM. Nasal-ocular reflexes and their role in the management of allergic rhinoconjunctivitis with intranasal steroids. World Allergy Organ J. 2011;4(1):S1-5doi: 10.1097/WOX.0b013e3181f32dcd.
Baroody, F. M., & Naclerio, R. M. (2011). Nasal-ocular reflexes and their role in the management of allergic rhinoconjunctivitis with intranasal steroids. The World Allergy Organization journal, 4(1), S1-5. https://doi.org/10.1097/WOX.0b013e3181f32dcd
Baroody, Fuad M, and Naclerio, Robert M. "Nasal-ocular reflexes and their role in the management of allergic rhinoconjunctivitis with intranasal steroids." The World Allergy Organization journal vol. 4,1 (2011): S1-5. doi: https://doi.org/10.1097/WOX.0b013e3181f32dcd
Baroody FM, Naclerio RM. Nasal-ocular reflexes and their role in the management of allergic rhinoconjunctivitis with intranasal steroids. World Allergy Organ J. 2011 Jan;4(1):S1-5. doi: 10.1097/WOX.0b013e3181f32dcd. PMID: 23283068; PMCID: PMC3666181.
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World Allergy Organ J. 2011 Jan;4(1):S1-5. doi: 10.1097/WOX.0b013e3181f32dcd.

Nasal-ocular reflexes and their role in the management of allergic rhinoconjunctivitis with intranasal steroids.

The World Allergy Organization journal

Fuad M Baroody, Robert M Naclerio

Affiliations

  1. From the Department of Surgery, Section of Otolaryngology-Head and Neck Surgery, The University of Chicago Medical Center, Chicago, IL.

PMID: 23283068 PMCID: PMC3666181 DOI: 10.1097/WOX.0b013e3181f32dcd

Abstract

Allergic rhinitis is a common disorder and involves the reaction to environmental allergens with resultant nasal and eye symptoms. The pathophysiologic mechanisms of the eye symptoms in allergic conjunctivitis include a direct effect on the eye by deposited allergen and indirect effects related to the deposition of allergen in the nasal mucosa. One of these proposed mechanisms is the existence of a nasal-ocular reflex whereby the nasal allergic reaction leads to an afferent reflex response, the efferent limb of which results in eye symptoms. Among the treatments available for allergic rhinitis, intranasal steroids are most efficacious for nasal symptoms and have also shown sizeable efficacy related to eye symptoms. We speculated that the effect of intranasal steroids on eye symptoms in allergic rhinitis was related to their inhibition of the nasal-ocular reflex and present data previously generated from our laboratory to support this assumption in a nasal challenge model.

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