Display options
Cite
Camera L, Campanile F, Imbriaco M, et al. Idiopathic pulmonary fibrosis complicated by acute thromboembolic disease: chest X-ray, HRCT and multi-detector row CT angiographic findings. J Thorac Dis. 2013;5(1):82-6doi: 10.3978/j.issn.2072-1439.2012.12.03.
Camera, L., Campanile, F., Imbriaco, M., Ippolito, R., Sirignano, C., Santoro, C., Galderisi, M., & Salvatore, M. (2013). Idiopathic pulmonary fibrosis complicated by acute thromboembolic disease: chest X-ray, HRCT and multi-detector row CT angiographic findings. Journal of thoracic disease, 5(1), 82-6. https://doi.org/10.3978/j.issn.2072-1439.2012.12.03
Camera, Luigi, et al. "Idiopathic pulmonary fibrosis complicated by acute thromboembolic disease: chest X-ray, HRCT and multi-detector row CT angiographic findings." Journal of thoracic disease vol. 5,1 (2013): 82-6. doi: https://doi.org/10.3978/j.issn.2072-1439.2012.12.03
Camera L, Campanile F, Imbriaco M, Ippolito R, Sirignano C, Santoro C, Galderisi M, Salvatore M. Idiopathic pulmonary fibrosis complicated by acute thromboembolic disease: chest X-ray, HRCT and multi-detector row CT angiographic findings. J Thorac Dis. 2013 Feb;5(1):82-6. doi: 10.3978/j.issn.2072-1439.2012.12.03. PMID: 23372953; PMCID: PMC3548011.
Copy Download .nbib Format: NLM
Share it on

J Thorac Dis. 2013 Feb;5(1):82-6. doi: 10.3978/j.issn.2072-1439.2012.12.03.

Idiopathic pulmonary fibrosis complicated by acute thromboembolic disease: chest X-ray, HRCT and multi-detector row CT angiographic findings.

Journal of thoracic disease

Luigi Camera, Francesco Campanile, Massimo Imbriaco, Renato Ippolito, Cesare Sirignano, Ciro Santoro, Maurizio Galderisi, Marco Salvatore

Affiliations

  1. Department of Radiology - University "Federico II" - Naples, Italy ; Institute of Biostructures - University "Federico II" - Naples, Italy.

PMID: 23372953 PMCID: PMC3548011 DOI: 10.3978/j.issn.2072-1439.2012.12.03

Abstract

Idiopathic pulmonary fibrosis (IPF) is a chronic diffuse interstitial disease characterized by a predominant reticular pattern of involvement of the lung parenchyma which can be well documented by High Resolution Computed Tomography (HRCT). While almost half of the patients with IPF may develop pulmonary arterial hypertension, the occurrence of superimposed acute thrombo-embolic disease is rare.We describe a case of an 87 yrs old female who was found to have IPF complicated by acute pulmonary thrombo-embolism during the clinical and radiological investigation of a rapidly worsening dyspnea. While chest x-ray findings were initially considered consistent with a congestive heart failure, a bed side echocardiography revealed findings suggestive of pulmonary arterial hypertension and right ventricular failure with enlargement of both right cavities and associated valvular regurgitations. An acute thrombo-embolic disease was initially ruled out by a perfusion lung scintigraphy and subsequently confirmed by contrast-enhanced multi-detector CT which showed an embolus at the emergency of the right inter-lobar artery with associated signs of chronic pulmonary hypertension. However, unenhanced scans performed with both conventional and high resolution techniques also depicted a reticular pattern of involvement of lung parenchyma considered suggestive of IPF despite a atypical upper lobe predominance. IPF was later confirmed by further clinical, serological and instrumental follow-up.

Keywords: Idiopathic pulmonary fibrosis; high resolution computed tomography; multidetector row CT angiography; pulmonary thrombo-embolism

References

  1. Am J Respir Crit Care Med. 2001 Oct 1;164(7):1171-81 - PubMed
  2. Am J Respir Crit Care Med. 2000 Feb;161(2 Pt 1):646-64 - PubMed
  3. J Comput Assist Tomogr. 2009 May-Jun;33(3):410-5 - PubMed
  4. Am J Respir Crit Care Med. 2012 Jul 1;186(1):88-95 - PubMed
  5. J Thorac Dis. 2012 Aug;4(4):398-407 - PubMed
  6. Eur Respir Rev. 2012 Jun 1;21(124):141-6 - PubMed
  7. Chest. 2003 Oct;124(4):1215-23 - PubMed
  8. Chest. 2006 Mar;129(3):746-52 - PubMed
  9. Am J Respir Crit Care Med. 2010 May 15;181(10):1085-92 - PubMed
  10. AJR Am J Roentgenol. 1993 Oct;161(4):719-25 - PubMed
  11. Radiology. 2008 Jan;246(1):288-97 - PubMed
  12. Chest. 2005 Sep;128(3):1475-82 - PubMed
  13. Radiographics. 2010 Nov;30(7):1753-77 - PubMed
  14. Chest. 2005 Oct;128(4):2393-9 - PubMed
  15. Eur Respir J. 2009 Dec;34(6):1219-63 - PubMed
  16. Radiology. 2007 Nov;245(2):315-29 - PubMed
  17. Chest. 2007 Aug;132(2):637-50 - PubMed
  18. Chest. 1995 Jul;108(1):109-15 - PubMed
  19. AJR Am J Roentgenol. 2005 Dec;185(6):1531-9 - PubMed
  20. Radiology. 1993 Oct;189(1):133-6 - PubMed

Publication Types