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Tariq M, Iqbal Z, Ali J, et al. Treatment modalities and evaluation models for periodontitis. Int J Pharm Investig. 2012;2(3):106-22doi: 10.4103/2230-973X.104394.
Tariq, M., Iqbal, Z., Ali, J., Baboota, S., Talegaonkar, S., Ahmad, Z., & Sahni, J. K. (2012). Treatment modalities and evaluation models for periodontitis. International journal of pharmaceutical investigation, 2(3), 106-22. https://doi.org/10.4103/2230-973X.104394
Tariq, Mohammad, et al. "Treatment modalities and evaluation models for periodontitis." International journal of pharmaceutical investigation vol. 2,3 (2012): 106-22. doi: https://doi.org/10.4103/2230-973X.104394
Tariq M, Iqbal Z, Ali J, Baboota S, Talegaonkar S, Ahmad Z, Sahni JK. Treatment modalities and evaluation models for periodontitis. Int J Pharm Investig. 2012 Jul;2(3):106-22. doi: 10.4103/2230-973X.104394. PMID: 23373002; PMCID: PMC3555006.
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Int J Pharm Investig. 2012 Jul;2(3):106-22. doi: 10.4103/2230-973X.104394.

Treatment modalities and evaluation models for periodontitis.

International journal of pharmaceutical investigation

Mohammad Tariq, Zeenat Iqbal, Javed Ali, Sanjula Baboota, Sushama Talegaonkar, Zulfiqar Ahmad, Jasjeet K Sahni

Affiliations

  1. Department of Pharmaceutics, Faculty of Pharmacy, Jamia Hamdard, Hamdard Nagar, New Delhi-110062, India.

PMID: 23373002 PMCID: PMC3555006 DOI: 10.4103/2230-973X.104394

Abstract

Periodontitis is the most common localized dental inflammatory disease related with several pathological conditions like inflammation of gums (gingivitis), degeneration of periodontal ligament, dental cementum and alveolar bone loss. In this perspective, the various preventive and treatment modalities, including oral hygiene, gingival irrigations, mechanical instrumentation, full mouth disinfection, host modulation and antimicrobial therapy, which are used either as adjunctive treatments or as stand-alone therapies in the non-surgical management of periodontal infections, have been discussed. Intra-pocket, sustained release systems have emerged as a novel paradigm for the future research. In this article, special consideration is given to different locally delivered anti-microbial and anti inflammatory medications which are either commercially available or are currently under consideration for Food and Drug Administration (FDA) approval. The various in vitro dissolution models and microbiological strain investigated to impersonate the infected and inflamed periodontal cavity and to predict the in vivo performance of treatment modalities have also been thrashed out. Animal models that have been employed to explore the pathology at the different stages of periodontitis and to evaluate its treatment modalities are enlightened in this proposed review.

Keywords: Chemotherapeutic agents; intra-pocket devices; mechanical therapies; oral hygiene

References

  1. J Clin Periodontol. 1980 Aug;7(4):300-8 - PubMed
  2. Periodontol 2000. 1997 Jun;14:173-201 - PubMed
  3. J Pharm Pharmacol. 1989 Oct;41(10):694-9 - PubMed
  4. J Periodontal Res. 1974;9(2):73-80 - PubMed
  5. J Dent Res. 1992 Sep;71(9):1577-81 - PubMed
  6. J Periodontol. 1965 May-Jun;36:177-87 - PubMed
  7. J Clin Periodontol. 1990 Aug;17(7 ( Pt 2)):479-93 - PubMed
  8. J Periodontol. 2002 Apr;73(4):460-70 - PubMed
  9. J Periodontal Res. 2002 Dec;37(6):433-8 - PubMed
  10. J Periodontol. 2002 Jul;73(7):694-700 - PubMed
  11. Am J Vet Res. 2000 Nov;61(11):1349-52 - PubMed
  12. Int J Pharm. 2005 Dec 8;306(1-2):24-40 - PubMed
  13. J Clin Periodontol. 2001 Oct;28(10):910-6 - PubMed
  14. J Periodontol. 1998 Feb;69(2):269-78 - PubMed
  15. J Periodontol. 1994 Mar;65(3):224-9 - PubMed
  16. J Periodontol. 1994 Dec;65(12):1158-68 - PubMed
  17. J Clin Periodontol. 1995 Nov;22(11):860-7 - PubMed
  18. J Dent Res. 1996 Jun;75(6):1338-41 - PubMed
  19. Int J Dent Hyg. 2007 Nov;5(4):225-31 - PubMed
  20. Drug Discov Today. 2008 Nov;13(21-22):932-43 - PubMed
  21. J Nanosci Nanotechnol. 2007 Nov;7(11):3695-9 - PubMed
  22. J Periodontal Res. 1968;3(4):268-72 - PubMed
  23. J Comp Pathol. 1974 Apr;84(2):143-50 - PubMed
  24. J Periodontol. 1998 Sep;69(9):1036-43 - PubMed
  25. J Drug Target. 1997;5(1):25-34 - PubMed
  26. J Clin Periodontol. 1978 Nov;5(4):246-71 - PubMed
  27. New Microbiol. 2006 Apr;29(2):101-10 - PubMed
  28. J Clin Periodontol. 2004 Mar;31(3):193-9 - PubMed
  29. J Periodontal Res. 2004 Apr;39(2):111-9 - PubMed
  30. J Periodontol. 1993 Jun;64(6):497-508 - PubMed
  31. J Clin Periodontol. 2004 Jun;31(6):428-33 - PubMed
  32. Acta Odontol Latinoam. 2010;23(2):158-63 - PubMed
  33. J Control Release. 2007 May 14;119(1):59-68 - PubMed
  34. Fogorv Sz. 2007 Jun;100(3):109-13 - PubMed
  35. Int J Pharm. 2008 Jun 24;358(1-2):23-6 - PubMed
  36. J Periodontol. 1989 Jun;60(6):302-9 - PubMed
  37. J Am Dent Assoc. 1995 Oct;126(10):1384-93 - PubMed
  38. J Biomed Mater Res A. 2008 Jun 1;85(3):707-14 - PubMed
  39. Drug Dev Ind Pharm. 2006 Apr;32(4):473-81 - PubMed
  40. Periodontol 2000. 2007;43:294-315 - PubMed
  41. J Dent. 1988 Dec;16(6):247-57 - PubMed
  42. J Periodontal Res. 1980 Jan;15(1):90-5 - PubMed
  43. J Periodontal Res. 1975 Nov;10(5):243-55 - PubMed
  44. J Int Acad Periodontol. 2008 Jan;10(1):31-5 - PubMed
  45. Bull Tokyo Med Dent Univ. 1984 Sep;31(3):145-53 - PubMed
  46. J Clin Periodontol. 1996 Dec;23(12):1133-6 - PubMed
  47. J Microencapsul. 1997 Mar-Apr;14(2):175-87 - PubMed
  48. J Periodontol. 2008 Feb;79(2):271-82 - PubMed
  49. J Periodontol. 2000 Jul;71(7):1086-93 - PubMed
  50. J Periodontol. 2004 Sep;75(9):1227-32 - PubMed
  51. Biomaterials. 2004 Aug;25(17):3743-50 - PubMed
  52. Drug Deliv. 2006 Mar-Apr;13(2):105-11 - PubMed
  53. J Clin Periodontol. 1986 May;13(5):461-75 - PubMed
  54. AAPS PharmSciTech. 2007 Sep 14;8(3):E75 - PubMed
  55. J Periodontal Res. 1982 May;17(3):323-8 - PubMed
  56. J Clin Periodontol. 1997 Mar;24(3):158-65 - PubMed
  57. J Dent Res. 1990 Feb;69(2):447-50 - PubMed
  58. J Periodontol. 2009 Sep;80(9):1479-92 - PubMed
  59. J Periodontol. 1995 Nov;66(11):962-5 - PubMed
  60. J Clin Periodontol. 1994 Apr;21(4):230-9 - PubMed
  61. Dent Clin North Am. 2010 Jan;54(1):13-33 - PubMed
  62. J Periodontol. 2005 Nov;76(11):2015-27 - PubMed
  63. J Clin Periodontol. 1984 Jul;11(6):379-86 - PubMed
  64. Am J Orthod Dentofacial Orthop. 1991 Oct;100(4):324-9 - PubMed
  65. Pharmazie. 2003 Oct;58(10):716-20 - PubMed
  66. J Periodontal Res. 1975 Jul;10(3):115-27 - PubMed
  67. J Periodontal Res. 1991 Sep;26(5):440-51 - PubMed
  68. J Pharm Sci. 2007 Aug;96(8):2074-89 - PubMed
  69. Drug Dev Ind Pharm. 2004 Feb;30(2):195-203 - PubMed
  70. J Dent Res. 1970 Mar-Apr;49(2):203-22 - PubMed
  71. Biomaterials. 1998 Jul;19(14):1295-301 - PubMed
  72. Can Fam Physician. 1988 Jun;34:1395-7 - PubMed
  73. Periodontol 2000. 2004;36:59-97 - PubMed
  74. Complement Ther Med. 2008 Oct;16(5):262-7 - PubMed
  75. Periodontol 2000. 2004;36:166-78 - PubMed
  76. J Clin Periodontol. 2009 Mar;36(3):240-9 - PubMed
  77. J Clin Periodontol. 2004 Mar;31(3):166-72 - PubMed
  78. J Clin Periodontol. 1991 Jul;18(6):441-6 - PubMed
  79. J Periodontol. 1988 Sep;59(9):557-64 - PubMed
  80. Arch Oral Biol. 1964 Jul-Aug;9:401-14 - PubMed
  81. J Clin Periodontol. 1995 Jun;22(6):427-33 - PubMed
  82. Acta Odontol Scand. 2006 Jun;64(3):153-8 - PubMed
  83. J Periodontal Res. 1980 May;15(3):341-4 - PubMed
  84. J Clin Periodontol. 2005 Jul;32(7):773-7 - PubMed
  85. Periodontol 2000. 2009;50:39-51 - PubMed
  86. J Periodontol. 2006 Apr;77(4):565-78 - PubMed
  87. Int J Pharm. 2002 Mar 20;235(1-2):121-7 - PubMed
  88. Int J Pharm. 2004 Apr 15;274(1-2):167-83 - PubMed
  89. J Clin Periodontol. 2008 Sep;35(9):783-8 - PubMed
  90. J Dent Res. 1984 Sep;63(9):1149-53 - PubMed
  91. J Periodontol. 1990 Jul;61(7):393-8 - PubMed
  92. J Periodontol. 2002 Jan;73(1):13-9 - PubMed
  93. Pharmazie. 2006 Jan;61(1):25-9 - PubMed
  94. J Periodontol. 2002 Jun;73(6):608-15 - PubMed
  95. Int J Pharm. 2003 Jun 18;259(1-2):47-55 - PubMed
  96. J Dent Res. 2008 Feb;87(2):148-52 - PubMed
  97. J Periodontal Res. 1985 Mar;20(2):165-75 - PubMed
  98. J Clin Periodontol. 1998 Nov;25(11 Pt 2):964-8; discussion 978-9 - PubMed
  99. J Clin Periodontol. 1995 Nov;22(11):824-9 - PubMed
  100. J Dent. 1991 Apr;19(2):92-6 - PubMed
  101. J Clin Periodontol. 2004 Sep;31(9):697-707 - PubMed
  102. Arch Oral Biol. 1970 Oct;15(10):993-5 - PubMed
  103. J Clin Periodontol. 1986 Aug;13(7):666-70 - PubMed
  104. J Clin Periodontol. 2002 May;29 Suppl 2:6-16 - PubMed
  105. J Periodontal Res. 1974;9(2):108-13 - PubMed
  106. J Periodontol. 1994 Dec;65(12):1143-50 - PubMed
  107. J Clin Periodontol. 1990 Sep;17(8):533-41 - PubMed
  108. J Periodontol. 1994 Mar;65(3):260-7 - PubMed
  109. Am J Vet Res. 1998 Apr;59(4):464-7 - PubMed
  110. J Periodontol. 1997 Nov;68(11):1131-5 - PubMed
  111. Drug Dev Ind Pharm. 2008 Mar;34(3):267-78 - PubMed
  112. Drug Deliv. 2010 Sep-Oct;17(7):520-31 - PubMed
  113. Pharm Res. 1996 Nov;13(11):1734-8 - PubMed
  114. J Periodontol. 2010 Feb;81(2):214-22 - PubMed
  115. Compend Contin Educ Dent. 2002 May;23(5 Suppl):15-21 - PubMed
  116. J Clin Periodontol. 1983 Nov;10(6):590-601 - PubMed
  117. J Periodontol. 2008 Nov;79(11):2125-35 - PubMed
  118. J Clin Periodontol. 2000 Jan;27(1):30-6 - PubMed
  119. J Periodontol. 1997 Feb;68(2):119-26 - PubMed
  120. J Periodontal Res. 1986 Jan;21(1):5-12 - PubMed
  121. J Pharm Pharm Sci. 2006;9(2):169-89 - PubMed
  122. J Periodontal Res. 2003 Feb;38(1):97-103 - PubMed
  123. J Clin Periodontol. 1999 Jun;26(6):335-40 - PubMed
  124. J Periodontol. 2004 Feb;75(2):243-8 - PubMed
  125. Biochem Biophys Res Commun. 2010 Dec 17;403(3-4):345-50 - PubMed
  126. Arch Oral Biol. 2005 Jan;50(1):39-48 - PubMed
  127. J Clin Periodontol. 1999 Feb;26(2):124-30 - PubMed
  128. Can Fam Physician. 1988 Jun;34:1391-2 - PubMed
  129. J Periodontol. 1992 Jan;63(1):2-6 - PubMed
  130. J Periodontol. 2008 Aug;79(8):1465-73 - PubMed
  131. J Microencapsul. 2004 Sep;21(6):643-52 - PubMed
  132. J Periodontol. 1973 Aug;44(8):454-63 - PubMed
  133. J Clin Periodontol. 1981 Jun;8(3):189-202 - PubMed
  134. Int J Pharm. 2005 Apr 27;294(1-2):217-32 - PubMed
  135. BMC Oral Health. 2006 Jun 15;6 Suppl 1:S14 - PubMed
  136. Dent Clin North Am. 2005 Jul;49(3):611-36, vii - PubMed
  137. J Clin Periodontol. 2001 Dec;28(12):1115-20 - PubMed
  138. Ann Periodontol. 1996 Nov;1(1):443-90 - PubMed
  139. J Clin Periodontol. 1992 May;19(5):340-4 - PubMed
  140. Drug Dev Ind Pharm. 2002 Aug;28(7):849-62 - PubMed
  141. J Periodontal Res. 1990 Jul;25(4):243-9 - PubMed
  142. J Periodontol. 1975 Nov;46(11):677-80 - PubMed
  143. J Int Acad Periodontol. 2010 Jan;12(1):11-9 - PubMed
  144. Taehan Chikkwa Uisa Hyophoe Chi. 1990 Mar;28(3):279-90 - PubMed
  145. J Periodontol. 1997 Apr;68(4):353-61 - PubMed
  146. Biochim Biophys Acta. 1994 Jul 13;1193(1):48-54 - PubMed
  147. Drug Deliv. 2006 Sep-Oct;13(5):365-73 - PubMed
  148. J Control Release. 2000 Jul 31;68(1):63-72 - PubMed
  149. Pharm Res. 1994 Nov;11(11):1605-9 - PubMed
  150. J Periodontol. 2008 May;79(5):827-35 - PubMed
  151. Eur J Pharm Biopharm. 2005 Jan;59(1):207-16 - PubMed
  152. J Periodontol. 1976 Sep;47(9):506-10 - PubMed
  153. Recent Pat Drug Deliv Formul. 2008;2(1):58-67 - PubMed
  154. J Clin Periodontol. 1987 Apr;14(4):190-6 - PubMed
  155. J Periodontol. 1990 Feb;61(2):112-7 - PubMed
  156. J Pharmacobiodyn. 1991 Feb;14(2):72-81 - PubMed
  157. J Clin Periodontol. 1985 Aug;12(7):568-77 - PubMed
  158. J Clin Periodontol. 1986 Jan;13(1):74-80 - PubMed
  159. J Clin Periodontol. 2004 Dec;31(12):1117-21 - PubMed
  160. Arch Oral Biol. 1975 Dec;20(12):775-82 - PubMed
  161. Drug Deliv. 2007 Nov;14(8):531-8 - PubMed
  162. J Periodontal Res. 1980 Jul;15(4):405-19 - PubMed
  163. J Clin Periodontol. 1994 Jan;21(1):32-7 - PubMed
  164. J Clin Periodontol. 1992 Oct;19(9 Pt 2):702-7 - PubMed
  165. J Periodontol. 1987 Dec;58(12):827-36 - PubMed
  166. Dent Mater. 2007 Apr;23(4):404-9 - PubMed
  167. J Mater Sci Mater Med. 2010 Aug;21(8):2435-42 - PubMed
  168. Diagn Microbiol Infect Dis. 1998 Feb;30(2):93-7 - PubMed
  169. J Periodontol. 1992 Apr;63(4 Suppl):338-55 - PubMed
  170. J Pharm Sci. 1988 May;77(5):428-31 - PubMed
  171. J Clin Periodontol. 1996 Aug;23(8):782-8 - PubMed
  172. J Biomed Mater Res. 2000 Sep 5;51(3):500-3 - PubMed
  173. Scand J Dent Res. 1975 Nov;83(6):314-26 - PubMed
  174. J Clin Periodontol. 1982 Mar;9(2):129-33 - PubMed
  175. Crit Rev Oral Biol Med. 1993;4(2):177-96 - PubMed
  176. J Int Acad Periodontol. 2003 Apr;5(2):52-60 - PubMed
  177. Arch Oral Biol. 1964 Jul-Aug;9:377-400 - PubMed
  178. J Biomed Mater Res B Appl Biomater. 2007 Feb;80(2):290-6 - PubMed
  179. J Periodontol. 1997 Nov;68(11):1102-9 - PubMed
  180. Biomaterials. 1995 Mar;16(4):313-7 - PubMed
  181. Dent Today. 1998 Jul;17(7):76-8, 80-2 - PubMed
  182. J Dent Res. 1983 Jun;62(6):738-42 - PubMed
  183. J Periodontol. 2001 Nov;72(11):1535-44 - PubMed
  184. J Periodontol. 2003 Jul;74(7):1038-42 - PubMed
  185. Periodontal Clin Investig. 1999;21(1):6-9 - PubMed
  186. J Periodontol. 1989 Jan;60(1):4-11 - PubMed
  187. Scand J Dent Res. 1975 May;83(3):189-92 - PubMed
  188. Pharmazie. 2001 Jul;56(7):554-60 - PubMed
  189. J Clin Periodontol. 1981 Jun;8(3):177-88 - PubMed
  190. J Can Dent Assoc. 2010;76:a30 - PubMed
  191. J Clin Periodontol. 1979 Apr;6(2):83-92 - PubMed
  192. J Mater Sci Mater Med. 2007 Jun;18(6):1125-33 - PubMed
  193. Int J Pharm. 2003 Feb 18;252(1-2):1-9 - PubMed
  194. J Periodontol. 1993 Sep;64(9):835-43 - PubMed
  195. J Control Release. 2000 Jul 3;67(2-3):357-68 - PubMed
  196. J Control Release. 2004 Mar 24;95(3):521-33 - PubMed
  197. Stomatologiia (Mosk). 1997;76(4):18-22 - PubMed
  198. J Periodontol. 2008 Mar;79(3):431-9 - PubMed
  199. J Periodontol. 1989 Feb;60(2):113-7 - PubMed
  200. Br Dent J. 1947 Sep;83(6):126; passim - PubMed
  201. J Periodontol. 1996 Nov;67(11):1176-84 - PubMed
  202. J Periodontal Res. 1978 Jul;13(4):316-25 - PubMed
  203. Drug Dev Ind Pharm. 2004 Apr;30(4):347-57 - PubMed
  204. J Control Release. 2001 Apr 28;71(3):251-9 - PubMed

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