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Amsden GW, Foulds G, Thakker K. Pharmacokinetic study of azithromycin with fluconazole and cotrimoxazole (trimethoprim-sulfamethoxazole) in healthy volunteers. Clin Drug Investig. 2000;20(2):135-42doi: 10.2165/00044011-200020020-00008.
Amsden, G. W., Foulds, G., & Thakker, K. (2000). Pharmacokinetic study of azithromycin with fluconazole and cotrimoxazole (trimethoprim-sulfamethoxazole) in healthy volunteers. Clinical drug investigation, 20(2), 135-42. https://doi.org/10.2165/00044011-200020020-00008
Amsden, G W, et al. "Pharmacokinetic study of azithromycin with fluconazole and cotrimoxazole (trimethoprim-sulfamethoxazole) in healthy volunteers." Clinical drug investigation vol. 20,2 (2000): 135-42. doi: https://doi.org/10.2165/00044011-200020020-00008
Amsden GW, Foulds G, Thakker K. Pharmacokinetic study of azithromycin with fluconazole and cotrimoxazole (trimethoprim-sulfamethoxazole) in healthy volunteers. Clin Drug Investig. 2000;20(2):135-42. doi: 10.2165/00044011-200020020-00008. PMID: 23315355.
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Clin Drug Investig. 2000;20(2):135-42. doi: 10.2165/00044011-200020020-00008.

Pharmacokinetic study of azithromycin with fluconazole and cotrimoxazole (trimethoprim-sulfamethoxazole) in healthy volunteers.

Clinical drug investigation

G W Amsden, G Foulds, K Thakker

Affiliations

  1. The Clinical Pharmacology Research Center, Research Institute and Departments of Pharmacy and Medicine, Bassett Healthcare, Cooperstown, New York, USA, [email protected].

PMID: 23315355 DOI: 10.2165/00044011-200020020-00008

Abstract

BACKGROUND: Azithromycin, fluconazole and cotrimoxazole (trimethoprim-sulfamethoxazole; TMP/SMX) are all agents that are utilised for the treatment and/or prophylaxis of opportunistic infections in patients with AIDS.

OBJECTIVE: To characterise the potential for an interaction when azithromycin is coadministered with cotrimoxazole or with fluconazole.

DESIGN: Two separate nonblind randomised studies were conducted in healthy volunteers. During the fluconazole study the potential for fluconazole to adversely affect the pharmacokinetics of azithromycin was also studied.

PARTICIPANTS: 24 (cotrimoxazole) and 18 (fluconazole) healthy male and female volunteers.

RESULTS: The results of both studies indicated that neither the peak concentrations of nor the exposures (area under the concentration-time curve) to the test drugs were changed when azithromycin was coadministered. In addition, fluconazole did not significantly alter the pharmacokinetic parameters of azithromycin.

CONCLUSIONS: Azithromycin does not alter the bioavailability of either cotrimoxazole or fluconazole.

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