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Balink H, Verberne HJ, Bennink RJ, et al. A Rationale for the Use of F18-FDG PET/CT in Fever and Inflammation of Unknown Origin. Int J Mol Imaging. 2012;2012:165080doi: 10.1155/2012/165080.
Balink, H., Verberne, H. J., Bennink, R. J., & van Eck-Smit, B. L. (2012). A Rationale for the Use of F18-FDG PET/CT in Fever and Inflammation of Unknown Origin. International journal of molecular imaging, 2012165080. https://doi.org/10.1155/2012/165080
Balink, H, et al. "A Rationale for the Use of F18-FDG PET/CT in Fever and Inflammation of Unknown Origin." International journal of molecular imaging vol. 2012 (2012): 165080. doi: https://doi.org/10.1155/2012/165080
Balink H, Verberne HJ, Bennink RJ, van Eck-Smit BL. A Rationale for the Use of F18-FDG PET/CT in Fever and Inflammation of Unknown Origin. Int J Mol Imaging. 2012;2012:165080. doi: 10.1155/2012/165080. Epub 2012 Dec 17. PMID: 23316356; PMCID: PMC3534311.
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Int J Mol Imaging. 2012;2012:165080. doi: 10.1155/2012/165080. Epub 2012 Dec 17.

A Rationale for the Use of F18-FDG PET/CT in Fever and Inflammation of Unknown Origin.

International journal of molecular imaging

H Balink, H J Verberne, R J Bennink, B L F van Eck-Smit

Affiliations

  1. Department of Nuclear Medicine, Medical Center Leeuwarden, 8901 BR Leeuwarden, The Netherlands.

PMID: 23316356 PMCID: PMC3534311 DOI: 10.1155/2012/165080

Abstract

This review focuses on the diagnostic value of hybrid F18-FDG Positron Emission Tomography/Computerized tomography (PET/CT) in fever of unknown origin (FUO) and inflammation of unknown origin (IUO). Due to the wide range of possible causes both FUO and IUO remain a clinical challenge for both patients and physicians. In addition, the aetiology of IUO shows the same variation in diseases as the FUO spectrum and probably requires the same diagnostic approach as FUO. There are numerous historically used diagnostic approaches incorporating invasive and non-invasive, and imaging techniques, all with relative high specificity but limited sensitivity. This hampers the generalization of these diagnostic approaches. However, recently published reports show that F18-FDG PET/CT in FUO and IUO has a high sensitivity and a relative non-specificity for malignancy, infection and inflammation. This makes F18-FDG PET/CT an ideal diagnostic tool to start the diagnostic process and to guide subsequent focused diagnostic approaches with higher specificity. In addition, F18-FDG PET/CT has a relative high negative predictive value. Therefore F18 FDG PET/CT should be incorporated in the routine diagnostic work-up of patients with FUO and IUO, preferably at an early stage in the diagnostic process.

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