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Tomonari Y, Sato J, Wako Y, et al. Age-related Histological Findings in the Pineal Gland of Crl:CD(SD) Rats. J Toxicol Pathol. 2012;25(4):287-91doi: 10.1293/tox.25.287.
Tomonari, Y., Sato, J., Wako, Y., & Tsuchitani, M. (2012). Age-related Histological Findings in the Pineal Gland of Crl:CD(SD) Rats. Journal of toxicologic pathology, 25(4), 287-91. https://doi.org/10.1293/tox.25.287
Tomonari, Yuki, et al. "Age-related Histological Findings in the Pineal Gland of Crl:CD(SD) Rats." Journal of toxicologic pathology vol. 25,4 (2012): 287-91. doi: https://doi.org/10.1293/tox.25.287
Tomonari Y, Sato J, Wako Y, Tsuchitani M. Age-related Histological Findings in the Pineal Gland of Crl:CD(SD) Rats. J Toxicol Pathol. 2012 Dec;25(4):287-91. doi: 10.1293/tox.25.287. Epub 2012 Dec 20. PMID: 23345933; PMCID: PMC3517926.
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J Toxicol Pathol. 2012 Dec;25(4):287-91. doi: 10.1293/tox.25.287. Epub 2012 Dec 20.

Age-related Histological Findings in the Pineal Gland of Crl:CD(SD) Rats.

Journal of toxicologic pathology

Yuki Tomonari, Junko Sato, Yumi Wako, Minoru Tsuchitani

Affiliations

  1. Pathology Department, Kashima Laboratory, Nonclinical Research Center, Mitsubishi Chemical Medience Corporation, 14-1 Sunayama, Kamisu, Ibaraki 314-0255, Japan.

PMID: 23345933 PMCID: PMC3517926 DOI: 10.1293/tox.25.287

Abstract

To provide background data as the pathologic basis, the pineal glands of 190 male and 193 female Crl:CD(SD) rats at ages of 0-7, 51-58, 70-85 and 111 weeks were examined histologically in this study. Mineralization and fibrosis were common findings in the aged rats, whereas they were rarely found in the young ones; mineralization was present in 7, 44, 67 and 79% of males and in 0, 32, 67 and 79% in females, and fibrosis was present in 0, 29, 48 and 44% of males and 0, 18, 40 and 35% of females at ages of 0-7, 51-58, 70-85 and 111 weeks, respectively. Striated muscle fiber appeared regularly in the fibrosis region from 51-58 weeks of age when fibrosis increased, while the origin of this fiber remained unclear. Vacuolation of pineal cells also increased with age in both sexes, though the total incidence was low. There was a low incidence of lymphocytic infiltration in both sexes, but this was not related to age.

Keywords: age-related finding; pineal gland; rat; spontaneous lesion; striated muscle fiber

References

  1. J Pathol. 1972 Oct;108(2):137-44 - PubMed
  2. Bratisl Lek Listy. 2009;110(5):276-9 - PubMed
  3. Cell Tissue Res. 1978 Jul 5;190(2):349-55 - PubMed
  4. Acta Anat (Basel). 1976;94(4):533-44 - PubMed
  5. Biol Signals Recept. 1999 Jan-Apr;8(1-2):49-55 - PubMed
  6. J Anat. 1994 Feb;184 ( Pt 1):171-6 - PubMed
  7. Ann N Y Acad Sci. 1994 May 31;719:64-76 - PubMed
  8. Endokrynol Pol. 1978 Mar-Apr;29(2):167-72 - PubMed
  9. J Pineal Res. 2009 Aug;47(1):32-42 - PubMed
  10. J Vet Med Sci. 1999 Jan;61(1):41-4 - PubMed
  11. Gan. 1984 Sep;75(9):784-91 - PubMed
  12. Z Zellforsch Mikrosk Anat. 1972;128(2):227-40 - PubMed
  13. Arzneimittelforschung. 1997 Nov;47(11):1271-3 - PubMed
  14. Acta Anat (Basel). 1963;54:310-6 - PubMed
  15. J Vet Med Sci. 1991 Jun;53(3):527-9 - PubMed
  16. J Neuropathol Exp Neurol. 1976 Nov-Dec;35(6):613-21 - PubMed
  17. Acta Morphol Neerl Scand. 1970 Nov;8(2):119-31 - PubMed

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