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Pérez-Pérez ME, Avalos-Díaz E, Herrera-Esparza R. Autoantibodies in senear-usher syndrome: cross-reactivity or multiple autoimmunity?. Autoimmune Dis. 2012;2012:296214doi: 10.1155/2012/296214.
Pérez-Pérez, M. E., Avalos-Díaz, E., & Herrera-Esparza, R. (2012). Autoantibodies in senear-usher syndrome: cross-reactivity or multiple autoimmunity?. Autoimmune diseases, 2012296214. https://doi.org/10.1155/2012/296214
Pérez-Pérez, María Elena, et al. "Autoantibodies in senear-usher syndrome: cross-reactivity or multiple autoimmunity?." Autoimmune diseases vol. 2012 (2012): 296214. doi: https://doi.org/10.1155/2012/296214
Pérez-Pérez ME, Avalos-Díaz E, Herrera-Esparza R. Autoantibodies in senear-usher syndrome: cross-reactivity or multiple autoimmunity?. Autoimmune Dis. 2012;2012:296214. doi: 10.1155/2012/296214. Epub 2012 Dec 20. PMID: 23320149; PMCID: PMC3539423.
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Autoimmune Dis. 2012;2012:296214. doi: 10.1155/2012/296214. Epub 2012 Dec 20.

Autoantibodies in senear-usher syndrome: cross-reactivity or multiple autoimmunity?.

Autoimmune diseases

María Elena Pérez-Pérez, Esperanza Avalos-Díaz, Rafael Herrera-Esparza

Affiliations

  1. Department of Immunology, Universidad Autónoma de Zacatecas, Chepinque 306, Colonia Lomas de la Soledad, 98040 Zacatecas, ZAC, Mexico.

PMID: 23320149 PMCID: PMC3539423 DOI: 10.1155/2012/296214

Abstract

Senear-Usher syndrome or pemphigus erythematosus is a pathology that overlaps clinically and serologically with pemphigus foliaceus and lupus erythematosus. Skin biopsies of patients with pemphigus erythematosus reveal acantholysis and deposits of immunoglobulins in desmosomes, and they are positive in the lupus band test. In the present paper, we determined whether the autoantibodies associated with pemphigus erythematosus targeted a single antigen or multiple antigens as a result of the stimulation of independent B cell clones. Our present paper demonstrates that patients with pemphigus erythematosus produce both antiepithelial antibodies specific for desmoglein 1 and 3 and antinuclear antibodies specific for Ro, La, Sm, and double-stranded DNA antigens. After eluting specific anti-epithelial or anti-nuclear antibodies, which were recovered and tested using double-fluorescence assays, a lack of cross-reactivity was demonstrated between desmosomes and nuclear and cytoplasmic lupus antigens. This result suggests that autoantibodies in pemphigus erythematosus are directed against different antigens and that these autoantibodies are produced by independent clones. Given these clinical and serological data, we suggest that pemphigus erythematosus behaves as a multiple autoimmune disease.

References

  1. J Exp Med. 1995 May 1;181(5):1597-601 - PubMed
  2. Proc Natl Acad Sci U S A. 1988 May;85(10):3504-8 - PubMed
  3. J Cutan Med Surg. 2009 Mar-Apr;13(2):82-7 - PubMed
  4. Am J Dermatopathol. 2003 Oct;25(5):432-6 - PubMed
  5. Arch Dermatol Res. 2003 Aug;295(4):133-7 - PubMed
  6. Mod Rheumatol. 2009;19(3):219-28 - PubMed
  7. J Endocrinol Invest. 2005 Jun;28(6):558-60 - PubMed
  8. J Rheumatol. 1985 Dec;12(6):1109-17 - PubMed
  9. J Invest Dermatol. 1985 Dec;85(6):538-41 - PubMed
  10. J Am Acad Dermatol. 1999 Feb;40(2 Pt 1):167-70 - PubMed
  11. J Invest Dermatol. 2012 Mar;132(3 Pt 2):776-84 - PubMed
  12. Arch Dermatol. 2012 Oct;148(10):1173-8 - PubMed
  13. Arthritis Rheum. 1987 Nov;30(11):1205-13 - PubMed
  14. Semin Immunol. 2011 Apr;23(2):84-91 - PubMed
  15. Br J Dermatol. 1968 Apr;80(4):211-7 - PubMed
  16. Int J Dermatol. 2005 Jul;44(7):541-4 - PubMed
  17. Autoimmunity. 2012 May;45(3):253-63 - PubMed
  18. J Am Acad Dermatol. 1980 Aug;3(2):107-19 - PubMed
  19. J Clin Invest. 1971 Feb;50(2):350-9 - PubMed
  20. Arch Dermatol. 1982 Oct;118(10):723-42 - PubMed
  21. J Autoimmune Dis. 2008 Feb 15;5:1 - PubMed
  22. J Am Acad Dermatol. 1994 Sep;31(3 Pt 1):434-7 - PubMed
  23. J Invest Dermatol. 2002 May;118(5):806-11 - PubMed
  24. Autoimmunity. 2012 Feb;45(1):7-35 - PubMed
  25. Clin Exp Immunol. 2010 Nov;162(2):224-36 - PubMed
  26. Proc Natl Acad Sci U S A. 1995 Dec 5;92(25):11935-9 - PubMed
  27. J Invest Dermatol. 2003 Dec;121(6):1373-8 - PubMed

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