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Mediterr J Hematol Infect Dis. 2013;5(1):e2013008. doi: 10.4084/MJHID.2013.008. Epub 2013 Jan 02.

An urologic face of chronic lymphocytic leukemia: sequential prostatic and penis localization.

Mediterranean journal of hematology and infectious diseases

Giovanni D'Arena, Roberto Guariglia, Oreste Villani, Maria Carmen Martorelli, Giuseppe Pietrantuono, Giovanna Mansueto, Giuseppe Patitucci, Emilio Imbriani, Tommaso Masciandaro, Ludovica Borgia, Giulia Vita, Fiorella D'Auria, Teodora Statuto, Pellegrino Musto

Affiliations

  1. Department of Onco-Hematology, IRCCS "Centro di Riferimento Oncologico della Basilicata", Rionero in Vulture, Italy.

PMID: 23350021 PMCID: PMC3552818 DOI: 10.4084/MJHID.2013.008

Abstract

We report a patient with chronic lymphocytic leukemia (CLL) in whom a leukemic involvement of prostate and penis occurred in the advanced phase of his disease. Obstructive urinary symptoms were indicative of prostatic CLL infiltration, followed by the occurrence of an ulcerative lesion on the glans. Histologic examination confirmed the neoplastic B-cell infiltration. Both localizations responded to conventional treatments. A review of the literature confirms that leukemic involvement of the genito-urinary system is uncommon in CLL patients. However, it should be considered in CLL patients with urologic symptoms and a long history of the disease.

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