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Lin E, Symons JA. Volatile anaesthetic myocardial protection: a review of the current literature. HSR Proc Intensive Care Cardiovasc Anesth. 2010;2(2):105-9
Lin, E., & Symons, J. A. (2010). Volatile anaesthetic myocardial protection: a review of the current literature. HSR proceedings in intensive care & cardiovascular anesthesia, 2(2), 105-9.
Lin, E, and Symons, J A. "Volatile anaesthetic myocardial protection: a review of the current literature." HSR proceedings in intensive care & cardiovascular anesthesia vol. 2,2 (2010): 105-9.
Lin E, Symons JA. Volatile anaesthetic myocardial protection: a review of the current literature. HSR Proc Intensive Care Cardiovasc Anesth. 2010;2(2):105-9. PMID: 23440181; PMCID: PMC3484611.
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HSR Proc Intensive Care Cardiovasc Anesth. 2010;2(2):105-9.

Volatile anaesthetic myocardial protection: a review of the current literature.

HSR proceedings in intensive care & cardiovascular anesthesia

E Lin, J A Symons

Affiliations

  1. Department of Anaesthesia and Perioperative Medicine, Alfred Hospital, Monash University; Melbourne, Australia.

PMID: 23440181 PMCID: PMC3484611

Abstract

Ischaemic preconditioning is a powerful innate adaptive phenomenon whereby brief periods of sublethal ischaemia result in marked tolerance to subsequent lethal ischaemia. Halogenated anaesthetics have been shown to mimic ischaemic preconditioning, modifying and attenuating ischaemia reperfusion injury. This review aims to present the current animal and human data, discuss the possible mechanisms of action and review the clinical evidence for volatile anaesthetic-induced myocardial protection. There is class Ia evidence for the myocardial protective properties of sevoflurane and desflurane in low risk patients undergoing coronary artery bypass grafting surgery. These volatile anaesthetics have been shown to improve clinical outcomes and health economics following cardiac surgery, reducing intensive care and hospital stay. The evidence for the benefit of volatile anaesthetics in non-cardiac surgery is less robust and further large randomized controlled trials are required to elucidate this question.

Keywords: cardiac anaesthesia; ischaemic preconditioning; mechanisms; myocardial protection; outcomes; volatile anaesthetics

References

  1. Can J Anaesth. 2006 Sep;53(9):906-18 - PubMed
  2. J Cardiothorac Vasc Anesth. 2007 Aug;21(4):502-11 - PubMed
  3. Br J Anaesth. 1998 Dec;81(6):905-12 - PubMed
  4. J Am Coll Cardiol. 2007 Oct 23;50(17):1707-32 - PubMed
  5. Anesth Analg. 2003 Nov;97(5):1370-1376 - PubMed
  6. Anesthesiology. 2002 Jan;96(1):125-33 - PubMed
  7. Ann Card Anaesth. 2009 Jan-Jun;12(1):4-9 - PubMed
  8. Anesth Analg. 2001 May;92(5):1139-45 - PubMed
  9. Anesthesiology. 2002 Dec;97(6):1485-90 - PubMed
  10. Anesthesiology. 2003 Mar;98(3):712-8 - PubMed
  11. Physiol Rev. 2003 Oct;83(4):1113-51 - PubMed
  12. Can J Anaesth. 1996 Sep;43(9):890-9 - PubMed
  13. Anesthesiology. 2004 Aug;101(2):299-310 - PubMed
  14. Anesthesiology. 2002 Jul;97(1):33-41 - PubMed
  15. Circulation. 1986 Nov;74(5):1124-36 - PubMed
  16. Anesthesiology. 2002 Jul;97(1):4-14 - PubMed
  17. Anesthesiology. 2002 Jul;97(1):15-23 - PubMed
  18. J Cardiothorac Vasc Anesth. 2007 Oct;21(5):664-71 - PubMed
  19. Anesthesiology. 1997 Jan;86(1):188-95 - PubMed
  20. Br J Anaesth. 2006 Aug;97(2):127-36 - PubMed
  21. Anesthesiology. 2002 Apr;96(4):934-40 - PubMed
  22. Anesth Analg. 2007 Sep;105(3):629-40 - PubMed
  23. J Cardiothorac Vasc Anesth. 1995 Dec;9(6):706-12 - PubMed
  24. Anesth Analg. 2003 Oct;97(4):1025-1032 - PubMed
  25. HSR Proc Intensive Care Cardiovasc Anesth. 2009;1(4):34-43 - PubMed
  26. Anesthesiology. 1985 Jan;62(1):29-33 - PubMed
  27. Can J Anaesth. 1992 Oct;39(8):877-87 - PubMed
  28. Br J Anaesth. 2002 Sep;89(3):486-91 - PubMed
  29. Anesthesiology. 1999 Sep;91(3):701-12 - PubMed
  30. Br J Anaesth. 2003 Oct;91(4):551-65 - PubMed

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