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Landoni G, Bove T, Pasero D, et al. Fenoldopam to prevent renal replacement therapy after cardiac surgery. Design of the FENO-HSR study. HSR Proc Intensive Care Cardiovasc Anesth. 2010;2(2):111-7
Landoni, G., Bove, T., Pasero, D., Comis, M., Orando, S., Pinelli, F., Guarracino, F., Corcione, A., Galdieri, N., Zucchetti, M., Maglioni, E., Biagioli, B., Pala, G., Frontini, M., Caramelli, F., Persi, B., Renzini, M., Paoletti, F., Lorini, L., Morelli, A., Alvaro, G., Bianco, R., Pittarello, D., Manzato, A., Pedersini, G., Mizzi, A., Lojacono, N., Leoncini, P., Iovino, T., Cariello, C., Baldassarri, R., Camata, A. M., Padua, G., Frascaroli, G., Leonardi, S., Bignami, E., & Zangrillo, A. (2010). Fenoldopam to prevent renal replacement therapy after cardiac surgery. Design of the FENO-HSR study. HSR proceedings in intensive care & cardiovascular anesthesia, 2(2), 111-7.
Landoni, G, et al. "Fenoldopam to prevent renal replacement therapy after cardiac surgery. Design of the FENO-HSR study." HSR proceedings in intensive care & cardiovascular anesthesia vol. 2,2 (2010): 111-7.
Landoni G, Bove T, Pasero D, Comis M, Orando S, Pinelli F, Guarracino F, Corcione A, Galdieri N, Zucchetti M, Maglioni E, Biagioli B, Pala G, Frontini M, Caramelli F, Persi B, Renzini M, Paoletti F, Lorini L, Morelli A, Alvaro G, Bianco R, Pittarello D, Manzato A, Pedersini G, Mizzi A, Lojacono N, Leoncini P, Iovino T, Cariello C, Baldassarri R, Camata AM, Padua G, Frascaroli G, Leonardi S, Bignami E, Zangrillo A. Fenoldopam to prevent renal replacement therapy after cardiac surgery. Design of the FENO-HSR study. HSR Proc Intensive Care Cardiovasc Anesth. 2010;2(2):111-7. PMID: 23440680; PMCID: PMC3484615.
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HSR Proc Intensive Care Cardiovasc Anesth. 2010;2(2):111-7.

Fenoldopam to prevent renal replacement therapy after cardiac surgery. Design of the FENO-HSR study.

HSR proceedings in intensive care & cardiovascular anesthesia

G Landoni, T Bove, D Pasero, M Comis, S Orando, F Pinelli, F Guarracino, A Corcione, N Galdieri, M Zucchetti, E Maglioni, B Biagioli, G Pala, M Frontini, F Caramelli, B Persi, M Renzini, F Paoletti, L Lorini, A Morelli, G Alvaro, R Bianco, D Pittarello, A Manzato, G Pedersini, A Mizzi, N Lojacono, P Leoncini, T Iovino, C Cariello, R Baldassarri, A M Camata, G Padua, G Frascaroli, S Leonardi, E Bignami, A Zangrillo

Affiliations

  1. Università Vita-Salute San Raffaele, Milano.

PMID: 23440680 PMCID: PMC3484615

Abstract

INTRODUCTION: Acute kidney injury requiring renal replacement therapy is a serious complication following cardiac surgery associated with poor clinical outcomes. Until now no drug showed nephroprotective effects. Fenoldopam is a dopamine-1 receptor agonist which seems to be effective in improving postoperative renal function. The aim of this paper is to describe the design of the FENO-HSR study, planned to assess the effect of a continuous infusion of fenoldopam in reducing the need for renal replacement therapy in patients with acute kidney injury after cardiac surgery.

METHODS: We're performing a double blind, placebo-controlled multicentre randomized trial in over 20 Italian hospitals. Patients who develop acute renal failure defined as R of RIFLE score following cardiac surgery are randomized to receive a 96-hours continuous infusion of either fenoldopam (0.025-0.3 µg/kg/min) or placebo.

RESULTS: The primary endpoint will be the rate of renal replacement therapy. Secondary endpoints will be: mortality, time on mechanical ventilation, length of intensive care unit and hospital stay, peak serum creatinine and the rate of acute renal failure (following the RIFLE score).

CONCLUSIONS: This trial is planned to assess if fenoldopam could improve relevant outcomes in patients undergoing cardiac surgery who develop acute renal dysfunction. Results of this double-blind randomized trial could provide important insights to improve the management strategy of patients at high risk for postoperative acute kidney injury.

Keywords: acute renal failure; anesthesia; cardiac surgery; cardiac surgical procedures; fenoldopam; renal replacement therapy

References

  1. Am J Kidney Dis. 2005 Jul;46(1):26-34 - PubMed
  2. Circulation. 2006 Nov 21;114(21):2208-16; quiz 2208 - PubMed
  3. Anaesthesia. 2001 Oct;56(10):953-60 - PubMed
  4. J Cardiothorac Vasc Anesth. 2006 Apr;20(2):179-86 - PubMed
  5. Int J Artif Organs. 2008 Feb;31(2):179-89 - PubMed
  6. J Cardiothorac Vasc Anesth. 2003 Aug;17(4):491-4 - PubMed
  7. J Cardiothorac Vasc Anesth. 2004 Aug;18(4):442-5 - PubMed
  8. J Cardiothorac Vasc Anesth. 2007 Dec;21(6):847-50 - PubMed
  9. Eur J Anaesthesiol. 2007 Jan;24(1):100-1 - PubMed
  10. JAMA. 2007 Apr 25;297(16):1801-9 - PubMed
  11. J Am Soc Nephrol. 2005 Jan;16(1):162-8 - PubMed
  12. Am J Kidney Dis. 2007 Jan;49(1):56-68 - PubMed
  13. Circulation. 2005 Jun 21;111(24):3230-5 - PubMed
  14. Minerva Anestesiol. 2007 Nov;73(11):559-65 - PubMed
  15. Circulation. 1997 Feb 18;95(4):878-84 - PubMed
  16. Crit Care Med. 2008 May;36(5):1427-35 - PubMed
  17. J Cardiothorac Vasc Anesth. 2008 Feb;22(1):27-33 - PubMed
  18. Eur J Anaesthesiol. 2006 Jan;23(1):17-22 - PubMed

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