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Ong K, Villemagne VL, Bahar-Fuchs A, et al. (18)F-florbetaben Aβ imaging in mild cognitive impairment. Alzheimers Res Ther. 2013;5(1):4doi: 10.1186/alzrt158.
Ong, K., Villemagne, V. L., Bahar-Fuchs, A., Lamb, F., Chételat, G., Raniga, P., Mulligan, R. S., Salvado, O., Putz, B., Roth, K., Masters, C. L., Reininger, C. B., & Rowe, C. C. (2013). (18)F-florbetaben Aβ imaging in mild cognitive impairment. Alzheimer's research & therapy, 5(1), 4. https://doi.org/10.1186/alzrt158
Ong, Kevin, et al. "(18)F-florbetaben Aβ imaging in mild cognitive impairment." Alzheimer's research & therapy vol. 5,1 (2013): 4. doi: https://doi.org/10.1186/alzrt158
Ong K, Villemagne VL, Bahar-Fuchs A, Lamb F, Chételat G, Raniga P, Mulligan RS, Salvado O, Putz B, Roth K, Masters CL, Reininger CB, Rowe CC. (18)F-florbetaben Aβ imaging in mild cognitive impairment. Alzheimers Res Ther. 2013 Jan 16;5(1):4. doi: 10.1186/alzrt158. eCollection 2013. PMID: 23324163; PMCID: PMC3580329.
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Alzheimers Res Ther. 2013 Jan 16;5(1):4. doi: 10.1186/alzrt158. eCollection 2013.

(18)F-florbetaben Aβ imaging in mild cognitive impairment.

Alzheimer's research & therapy

Kevin Ong, Victor L Villemagne, Alex Bahar-Fuchs, Fiona Lamb, Gaël Chételat, Parnesh Raniga, Rachel S Mulligan, Olivier Salvado, Barbara Putz, Katrin Roth, Colin L Masters, Cornelia B Reininger, Christopher C Rowe

Affiliations

  1. Department of Nuclear Medicine and Centre for PET, Austin Health, 145 Studley Road, Heidelberg, VIC 3084, Australia.
  2. Department of Nuclear Medicine and Centre for PET, Austin Health, 145 Studley Road, Heidelberg, VIC 3084, Australia ; Department of Medicine, University of Melbourne, Parkville, VIC 3010, Australia ; Mental Health Research Institute, 155 Oak Street, Parkville, VIC 3052, Australia.
  3. Department of Nuclear Medicine and Centre for PET, Austin Health, 145 Studley Road, Heidelberg, VIC 3084, Australia ; Centre for Research on Aging, Health, and Wellbeing, 63 Eggleston Road, The Australian National University, Acton, ACT 2600, Australia.
  4. Department of Nuclear Medicine and Centre for PET, Austin Health, 145 Studley Road, Heidelberg, VIC 3084, Australia ; Mental Health Research Institute, 155 Oak Street, Parkville, VIC 3052, Australia.
  5. CSIRO Preventative Health National Research Flagship, The Australian e-Health Research Centre - BioMedIA, Herston, QLD 4029, Australia.
  6. Bayer Pharma AG, Müllerstraße 178, 13353 Berlin, Germany.
  7. Mental Health Research Institute, 155 Oak Street, Parkville, VIC 3052, Australia.
  8. Department of Nuclear Medicine and Centre for PET, Austin Health, 145 Studley Road, Heidelberg, VIC 3084, Australia ; Department of Medicine, University of Melbourne, Parkville, VIC 3010, Australia.

PMID: 23324163 PMCID: PMC3580329 DOI: 10.1186/alzrt158

Abstract

INTRODUCTION: (18)F-florbetaben and positron emission tomography were used to examine the relationships between β-amyloid (Aβ) deposition, cognition, hippocampal volume, and white matter hyperintensities in mild cognitive impairment (MCI).

METHODS: Forty-five MCI participants were evaluated. A neocortical standardized uptake value ratio threshold ≥ 1.45 was used to discriminate high from low Aβ burden. Correlations were adjusted for age, gender and years of education.

RESULTS: High Aβ burden was found in 53% of MCI. Regression analyses showed standardized uptake value ratio (r = -0.51, P = 0.0015) and hippocampal volume (r = 0.60, P = 0.024) both contributing to episodic memory impairment in independent fashion. White matter hyperintensities correlated with nonmemory cognition, and this correlation was particularly associated with Aβ burden.

CONCLUSION: Higher Aβ deposition in MCI is associated with more severe memory impairment and is contributing to early amnestic symptoms independent of hippocampal atrophy.

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