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Cianci R, Cammarota G, Frisullo G, et al. Tissue-infiltrating lymphocytes analysis reveals large modifications of the duodenal "immunological niche" in coeliac disease after gluten-free diet. Clin Transl Gastroenterol. 2012;3:e28doi: 10.1038/ctg.2012.22.
Cianci, R., Cammarota, G., Frisullo, G., Pagliari, D., Ianiro, G., Martini, M., Frosali, S., Plantone, D., Damato, V., Casciano, F., Landolfi, R., Paola Batocchi, A., & Pandolfi, F. (2012). Tissue-infiltrating lymphocytes analysis reveals large modifications of the duodenal "immunological niche" in coeliac disease after gluten-free diet. Clinical and translational gastroenterology, 3e28. https://doi.org/10.1038/ctg.2012.22
Cianci, Rossella, et al. "Tissue-infiltrating lymphocytes analysis reveals large modifications of the duodenal "immunological niche" in coeliac disease after gluten-free diet." Clinical and translational gastroenterology vol. 3 (2012): e28. doi: https://doi.org/10.1038/ctg.2012.22
Cianci R, Cammarota G, Frisullo G, Pagliari D, Ianiro G, Martini M, Frosali S, Plantone D, Damato V, Casciano F, Landolfi R, Paola Batocchi A, Pandolfi F. Tissue-infiltrating lymphocytes analysis reveals large modifications of the duodenal "immunological niche" in coeliac disease after gluten-free diet. Clin Transl Gastroenterol. 2012 Dec 13;3:e28. doi: 10.1038/ctg.2012.22. PMID: 23324655; PMCID: PMC3535075.
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Clin Transl Gastroenterol. 2012 Dec 13;3:e28. doi: 10.1038/ctg.2012.22.

Tissue-infiltrating lymphocytes analysis reveals large modifications of the duodenal "immunological niche" in coeliac disease after gluten-free diet.

Clinical and translational gastroenterology

Rossella Cianci, Giovanni Cammarota, Giovanni Frisullo, Danilo Pagliari, Gianluca Ianiro, Maurizio Martini, Simona Frosali, Domenico Plantone, Valentina Damato, Fabio Casciano, Raffaele Landolfi, Anna Paola Batocchi, Franco Pandolfi

Affiliations

  1. Institute of Internal Medicine, Catholic University, Rome, Italy.

PMID: 23324655 PMCID: PMC3535075 DOI: 10.1038/ctg.2012.22

Abstract

OBJECTIVES: The role of T lymphocytes in the pathogenesis of Celiac disease (CD) is well established. However, the mechanisms of T-cell involvement remain elusive. Little is known on the distribution of T subpopulations: T-regulatory (Treg), Th17, CD103, and CD62L cells at disease onset and after gluten-free diet (GFD). We investigated the involvement of several T subpopulations in the pathogenesis of CD.

METHODS: We studied T cells both in the peripheral blood (PB) and the tissue-infiltrating lymphocytes (TILs) from the mucosa of 14 CD patients at presentation and after a GFD, vs. 12 controls.

RESULTS: Our results extend the involvement of Treg, Th1, and Th17 cells in active CD inflammation both in the PB and at the TILs. At baseline, Tregs, Th1, and Th17 cells are significantly higher in active CD patients in TILs and PB. They decreased after diet. Moreover, CD62L+ TILs were increased at diagnosis as compared with GFD patients.

CONCLUSIONS: Our data show significant modifications of the above-mentioned subpopulations both in the PB and TILs. The increase of suppressive Tregs in active CD both in the PB and TILs is intriguing. T lymphocytes are known to have a crucial role in the pathogenesis of CD. We have shown that gluten trigger results in systemic recruitment of T lymphocytes, the unbalance between pro-inflammatory and anti-inflammatory populations and the increase of CD62L+ T cells in TILs. Our results delineate a more complete picture of T-cell subsets in active vs. GFD disease. Our data of T-cell subpopulations, combined with known data on cytokine production, support the concept that duodenal micro-environment acts as an immunological niche and this recognition may have an important role in the diagnosis, prognosis and therapeutical approach of CD.

References

  1. Ann N Y Acad Sci. 2008 Dec;1150:273-7 - PubMed
  2. J Biol Regul Homeost Agents. 2012 Apr-Jun;26(2):171-9 - PubMed
  3. J Biol Regul Homeost Agents. 2008 Apr-Jun;22(2):99-104 - PubMed
  4. J Biol Regul Homeost Agents. 2010 Jul-Sep;24(3):239-49 - PubMed
  5. J Immunol. 1999 Jun 1;162(11):6641-9 - PubMed
  6. Pathobiology. 2010;77(6):328-34 - PubMed
  7. Am J Gastroenterol. 2012 Apr;107(4):604-11 - PubMed
  8. Blood Cells. 1978;4(1-2):7-25 - PubMed
  9. Eur J Gastroenterol Hepatol. 2008 May;20(5):478-87 - PubMed
  10. N Engl J Med. 2007 Oct 25;357(17):1731-43 - PubMed
  11. J Exp Med. 2006 Jul 10;203(7):1701-11 - PubMed
  12. Clin Exp Immunol. 1999 Jun;116(3):388-94 - PubMed
  13. Clin Exp Immunol. 2009 Oct;158(1):106-14 - PubMed
  14. Gut. 1995 Dec;37(6):766-76 - PubMed
  15. Cancer Res. 1991 Jun 15;51(12):3164-70 - PubMed
  16. J Immunol. 2005 Oct 1;175(7):4355-62 - PubMed
  17. Nature. 1996 Jul 25;382(6589):366-70 - PubMed
  18. Gastroenterology. 2006 Dec;131(6):1981-2002 - PubMed
  19. Nat Rev Immunol. 2009 Dec;9(12):858-70 - PubMed
  20. J Pediatr Gastroenterol Nutr. 1999 Sep;29(3):308-13 - PubMed
  21. Autoimmunity. 2009 Jan;42(1):69-73 - PubMed
  22. Blood. 2011 Jul 7;118(1):148-55 - PubMed
  23. Int J Immunopathol Pharmacol. 2010 Jan-Mar;23(1):179-91 - PubMed
  24. Nat Rev Immunol. 2010 Jul;10(7):490-500 - PubMed
  25. Int Arch Allergy Immunol. 2010;152(1):75-80 - PubMed
  26. Nature. 2006 Jun 29;441(7097):1075-9 - PubMed
  27. Am J Gastroenterol. 2011 Jul;106(7):1308-17 - PubMed
  28. J Intern Med. 2011 Jun;269(6):560-71 - PubMed
  29. Am J Gastroenterol. 2011 Mar;106(3):528-38 - PubMed
  30. Mediators Inflamm. 2009;2009:132028 - PubMed
  31. J Immunol. 2009 Dec 15;183(12):8280-5 - PubMed
  32. Lancet. 2003 Aug 2;362(9381):383-91 - PubMed
  33. Gastroenterology. 2007 Mar;132(3):994-1008 - PubMed
  34. J Immunol. 2010 Feb 15;184(4):2211-8 - PubMed
  35. Gastroenterology. 1993 Sep;105(3):910-22 - PubMed
  36. Nat Rev Immunol. 2002 Sep;2(9):647-55 - PubMed
  37. Hum Immunol. 2009 Jun;70(6):430-5 - PubMed
  38. Clin Exp Immunol. 1983 Mar;51(3):470-4 - PubMed
  39. Proc Natl Acad Sci U S A. 1992 Sep 1;89(17):8254-8 - PubMed
  40. Scand J Gastroenterol. 2009;44(1):108-15 - PubMed
  41. Cell Immunol. 2006 Nov;244(1):1-9 - PubMed
  42. Curr Pharm Des. 2008;14(3):253-68 - PubMed
  43. Gastroenterology. 2002 Nov;123(5):1516-26 - PubMed
  44. Scand J Immunol. 2002 Dec;56(6):652-64 - PubMed
  45. Clin Exp Immunol. 2002 Apr;128(1):88-93 - PubMed

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