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Cho CW, Kim DB, Cho HW, et al. Enhanced Controlled Transdermal Delivery of Ambroxol from the EVA Matrix. Indian J Pharm Sci. 2012;74(2):127-32doi: 10.4103/0250-474X.103844.
Cho, C. W., Kim, D. B., Cho, H. W., & Shin, S. C. (2012). Enhanced Controlled Transdermal Delivery of Ambroxol from the EVA Matrix. Indian journal of pharmaceutical sciences, 74(2), 127-32. https://doi.org/10.4103/0250-474X.103844
Cho, C W, et al. "Enhanced Controlled Transdermal Delivery of Ambroxol from the EVA Matrix." Indian journal of pharmaceutical sciences vol. 74,2 (2012): 127-32. doi: https://doi.org/10.4103/0250-474X.103844
Cho CW, Kim DB, Cho HW, Shin SC. Enhanced Controlled Transdermal Delivery of Ambroxol from the EVA Matrix. Indian J Pharm Sci. 2012 Mar;74(2):127-32. doi: 10.4103/0250-474X.103844. PMID: 23325993; PMCID: PMC3546329.
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Indian J Pharm Sci. 2012 Mar;74(2):127-32. doi: 10.4103/0250-474X.103844.

Enhanced Controlled Transdermal Delivery of Ambroxol from the EVA Matrix.

Indian journal of pharmaceutical sciences

C W Cho, D B Kim, H W Cho, S C Shin

Affiliations

  1. College of Pharmacy, Chungnam National University, Daejeon-305 764, Korea.

PMID: 23325993 PMCID: PMC3546329 DOI: 10.4103/0250-474X.103844

Abstract

To avoid the systemic adverse effects that might occur after oral administration, transdermal delivery of ambroxol was studied as a method for maintaining proper blood levels for an extended period. Release of ambroxol according to concentration and temperature was determined, and permeation of drug through rat skin was studied using two chamber-diffusion cells. The solubility according to PEG 400 volume fraction was highest at 40% PEG 400. The rate of drug release from the EVA matrix increased with increased temperature and drug loading doses. A linear relationship existed between the release rate and the square root of loading rate. The activation energy (Ea) was measured from the slope of the plot of log P versus 1000/T and was found to be 10.71, 10.39, 10.33 and 9.87 kcal/mol for 2, 3, 4 and 5% loading dose from the EVA matrix, respectively. To increase the permeation rate of ambroxol across rat skin from the EVA matrix, various penetration enhancers such as fatty acids (saturated, unsaturated), propylene glycols, glycerides, pyrrolidones, and non-ionic surfactants were used. The enhancing effects of the incorporated enhancers on the skin permeation of ambroxol were evaluated using Franz diffusion cells fitted with intact excised rat skin at 37° using 40% PEG 400 solution as a receptor medium. Among the enhancers used, polyoxyethylene-2-oleyl ether increased the permeation rate by 4.25-fold. In conclusion, EVA matrix containing plasticizer and permeation enhancer could be developed for enhanced transdermal delivery of ambroxol.

Keywords: Ambroxol; EVA matrix; penetration enhancer; plasticizer; transdermal delivery

References

  1. J Pharm Sci. 1980 Jul;69(7):781-6 - PubMed
  2. J Pharm Sci. 1966 Nov;55(11):1224-9 - PubMed
  3. Respiration. 1987;51 Suppl 1:33-6 - PubMed
  4. Eur J Pharmacol. 2000 Oct 27;407(1-2):61-4 - PubMed
  5. Free Radic Biol Med. 1994 Apr;16(4):517-22 - PubMed
  6. J Pharm Sci. 1965 Oct;54(10):1459-64 - PubMed
  7. J Pharm Sci. 1976 Apr;65(4):488-92 - PubMed
  8. J Pharm Sci. 1963 Dec;52:1145-9 - PubMed
  9. Eur J Pharm Biopharm. 2000 Sep;50(2):217-20 - PubMed
  10. J Pharm Sci. 1971 Feb;60(2):212-5 - PubMed
  11. J Pharm Sci. 1961 Oct;50:874-5 - PubMed
  12. Chest. 1987 Oct;92(4):618-20 - PubMed

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