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Cardinali DP, Vigo DE, Olivar N, et al. Therapeutic application of melatonin in mild cognitive impairment. Am J Neurodegener Dis. 2012;1(3):280-91
Cardinali, D. P., Vigo, D. E., Olivar, N., Vidal, M. F., Furio, A. M., & Brusco, L. I. (2012). Therapeutic application of melatonin in mild cognitive impairment. American journal of neurodegenerative disease, 1(3), 280-91.
Cardinali, Daniel P, et al. "Therapeutic application of melatonin in mild cognitive impairment." American journal of neurodegenerative disease vol. 1,3 (2012): 280-91.
Cardinali DP, Vigo DE, Olivar N, Vidal MF, Furio AM, Brusco LI. Therapeutic application of melatonin in mild cognitive impairment. Am J Neurodegener Dis. 2012;1(3):280-91. Epub 2012 Nov 18. PMID: 23383398; PMCID: PMC3560473.
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Am J Neurodegener Dis. 2012;1(3):280-91. Epub 2012 Nov 18.

Therapeutic application of melatonin in mild cognitive impairment.

American journal of neurodegenerative disease

Daniel P Cardinali, Daniel E Vigo, Natividad Olivar, María F Vidal, Analía M Furio, Luis I Brusco

Affiliations

  1. Departamento de Docencia e Investigación, Facultad de Ciencias Médicas, Pontificia Universidad Católica Argentina Buenos Aires, Argentina.

PMID: 23383398 PMCID: PMC3560473

Abstract

Mild cognitive impairment (MCI) is an etiologically heterogeneous syndrome defined by cognitive impairment in advance of dementia. We previously reported in a retrospective analysis that daily 3 - 9 mg of a fast-release melatonin preparation given p. o. at bedtime for up to 3 years significantly improved cognitive and emotional performance and daily sleep/wake cycle in MCI patients. In a follow up of that study we now report data from another series of 96 MCI outpatients, 61 of who had received daily 3 - 24 mg of a fast-release melatonin preparation p. o. at bedtime for 15 to 60 months. Melatonin was given in addition to the standard medication prescribed by the attending psychiatrist. Patients treated with melatonin exhibited significantly better performance in Mini-Mental State Examination and the cognitive subscale of the Alzheimer's disease Assessment Scale. After application of a neuropsychological battery comprising a Mattis´ test, Digit-symbol test, Trail A and B tasks and the Rey´s verbal test, better performance was found in melatonin-treated patients for every parameter tested. Abnormally high Beck Depression Inventory scores decreased in melatonin-treated patients, concomitantly with the improvement in the quality of sleep and wakefulness. The comparison of the medication profile in both groups of MCI patients indicated that 9.8% in the melatonin group received benzodiazepines vs. 62.8% in the non-melatonin group. The results further support that melatonin can be a useful add-on drug for treating MCI in a clinic environment.

Keywords: Alzheimer´s disease; Mild cognitive impairment; benzodiazepines; melatonin; neuropsychological tests; retrospective study

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