Korean J Pediatr. 2012 Dec;55(12):481-6. doi: 10.3345/kjp.2012.55.12.481. Epub 2012 Dec 20.
Diagnosis and constitutional and laboratory features of Korean girls referred for precocious puberty.
Korean journal of pediatrics
Doosoo Kim, Sung-Yoon Cho, Se-Hyun Maeng, Eun Sang Yi, Yu Jin Jung, Sung Won Park, Young Bae Sohn, Dong-Kyu Jin
Affiliations
Affiliations
- Department of Pediatrics, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.
PMID: 23300504
PMCID: PMC3534162 DOI: 10.3345/kjp.2012.55.12.481
Abstract
PURPOSE: Precocious puberty is defined as breast development before the age of 8 years in girls. The present study aimed to reveal the diagnosis of Korean girls referred for precocious puberty and to compare the constitutional and endocrinological features among diagnosis groups.
METHODS: The present study used a retrospective chart review of 988 Korean girls who had visited a pediatric endocrinology clinic from 2006 to 2010 for the evaluation of precocious puberty. Study groups comprised fast puberty, true precocious puberty (PP), pseudo PP, premature thelarche, and control. We determined the height standard deviation score (HSDS), weight standard deviation score (WSDS), and body mass index standard deviation score (BMISDS) of each group using the published 2007 Korean growth charts. Hormone tests were performed at our outpatient clinic.
RESULTS: The PP groups comprised fast puberty (67%), premature thelarche (17%), true PP (15%), and pseudo PP (1%). Advanced bone age and levels of estradiol, basal luteinizing hormone (LH), and peak LH after gonadotropin-releasing hormone stimulation testing were significantly high in the fast puberty and true PP groups compared with the control group. HSDS, WSDS, and BMISDS were significantly higher in the true PP group than in the control group (P<0.05).
CONCLUSION: The frequent causes of PP were found to be fast puberty, true PP, and premature thelarche. Furthermore, BMISDS were significantly elevated in the true PP group. Therefore, we emphasize the need for regular follow-up of girls who are heavier or taller than others in the same age group.
Keywords: Body mass index; Precocious puberty; Premature thelarche; Puberty; Sexual maturation
References
- Pediatrics. 2009 Jan;123(1):84-8 - PubMed
- Hum Reprod Update. 2001 May-Jun;7(3):287-91 - PubMed
- J Clin Endocrinol Metab. 2004 Aug;89(8):3644-50 - PubMed
- Pediatrics. 2004 Apr;113(4):911-7 - PubMed
- Int J Androl. 2010 Apr;33(2):346-59 - PubMed
- Pediatrics. 1999 Oct;104(4 Pt 1):936-41 - PubMed
- Am J Hum Biol. 2004 Jul-Aug;16(4):453-7 - PubMed
- Pediatrics. 2001 Aug;108(2):347-53 - PubMed
- Int J Obes Relat Metab Disord. 2003 Aug;27(8):869-74 - PubMed
- J Clin Endocrinol Metab. 2002 May;87(5):2090-4 - PubMed
- Environ Health Perspect. 2005 Aug;113(8):1100-7 - PubMed
- Acta Paediatr Suppl. 1997 Nov;423:20-7 - PubMed
- Arch Dis Child. 1969 Jun;44(235):291-303 - PubMed
- Pediatrics. 2003 Apr;111(4 Pt 1):844-50 - PubMed
- Curr Opin Pediatr. 2008 Aug;20(4):458-64 - PubMed
- Helv Paediatr Acta. 1983 Aug;38(3):229-43 - PubMed
- J Clin Endocrinol Metab. 2011 May;96(5):1393-401 - PubMed
- Ethn Dis. 1999 Spring-Summer;9(2):181-9 - PubMed
- Pediatrics. 1997 Apr;99(4):505-12 - PubMed
- Ann Hum Biol. 2006 Jan-Feb;33(1):55-63 - PubMed
- Pediatrics. 2002 Nov;110(5):903-10 - PubMed
- Pediatrics. 2002 Oct;110(4):e43 - PubMed
- Hum Reprod Update. 2004 Mar-Apr;10(2):135-47 - PubMed
Publication Types