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Porto L, Miranda M, Gomes A, et al. Paraneoplastic neurological syndrome as an initial indicator of small cell carcinoma of the lung. BMJ Case Rep. 2013;2013doi: 10.1136/bcr-2012-008432.
Porto, L., Miranda, M., Gomes, A., André, R., & Rodrigues, B. (2013). Paraneoplastic neurological syndrome as an initial indicator of small cell carcinoma of the lung. BMJ case reports, 2013. https://doi.org/10.1136/bcr-2012-008432
Porto, Lénea, et al. "Paraneoplastic neurological syndrome as an initial indicator of small cell carcinoma of the lung." BMJ case reports vol. 2013 (2013). doi: https://doi.org/10.1136/bcr-2012-008432
Porto L, Miranda M, Gomes A, André R, Rodrigues B. Paraneoplastic neurological syndrome as an initial indicator of small cell carcinoma of the lung. BMJ Case Rep. 2013 Feb 06;2013. doi: 10.1136/bcr-2012-008432. PMID: 23391962; PMCID: PMC3603971.
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BMJ Case Rep. 2013 Feb 06;2013. doi: 10.1136/bcr-2012-008432.

Paraneoplastic neurological syndrome as an initial indicator of small cell carcinoma of the lung.

BMJ case reports

Lénea Porto, Mafalda Miranda, Ana Gomes, Rui André, Bárbara Rodrigues

Affiliations

  1. Internal Medicine Department, Centro Hospitalar Tondela-Viseu, Viseu, Portugal. [email protected]

PMID: 23391962 PMCID: PMC3603971 DOI: 10.1136/bcr-2012-008432

Abstract

Paraneoplastic syndromes are indirect manifestations of cancer due to functional peptides/hormones produced by a tumour, or due to cross reactivity between tumour and host antigens. Here the case of a 58-year-old woman presenting with ataxia, paraesthesia and subacute and progressive loss of vision is reported. The patient exhibited strong serum positivity for anti-Hu and anti-CV2 antibodies, and a chest CT scan showed a hypodense nodule in proximity of the right upper lobe bronchus and an enlarged ipsilateral paratracheal lymph node that was not visible on a lung x-ray. Histopathological examination of a biopsy specimen from this lymph node showed that small cell carcinoma of the lung was present. The patient's deficits were subsequently diagnosed as three coexisting paraneoplastic neurological syndromes (PNSs): subacute cerebellar ataxia, sensory neuropathy and retinopathy, respectively. Although rare, PNSs can be the first manifestations of cancer, and their rapid recognition facilitates an early treatment.

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