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Kim DH, Cheon JH, Park JJ, et al. Clinical outcomes and predictive factors for response after the first course of corticosteroid therapy in patients with Crohn's disease. Gut Liver. 2013;7(1):58-65doi: 10.5009/gnl.2013.7.1.58.
Kim, D. H., Cheon, J. H., Park, J. J., Yoon, J. Y., Moon, C. M., Hong, S. P., Kim, T. I., & Kim, W. H. (2013). Clinical outcomes and predictive factors for response after the first course of corticosteroid therapy in patients with Crohn's disease. Gut and liver, 7(1), 58-65. https://doi.org/10.5009/gnl.2013.7.1.58
Kim, Duk Hwan, et al. "Clinical outcomes and predictive factors for response after the first course of corticosteroid therapy in patients with Crohn's disease." Gut and liver vol. 7,1 (2013): 58-65. doi: https://doi.org/10.5009/gnl.2013.7.1.58
Kim DH, Cheon JH, Park JJ, Yoon JY, Moon CM, Hong SP, Kim TI, Kim WH. Clinical outcomes and predictive factors for response after the first course of corticosteroid therapy in patients with Crohn's disease. Gut Liver. 2013 Jan;7(1):58-65. doi: 10.5009/gnl.2013.7.1.58. Epub 2013 Jan 11. PMID: 23423699; PMCID: PMC3572321.
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Gut Liver. 2013 Jan;7(1):58-65. doi: 10.5009/gnl.2013.7.1.58. Epub 2013 Jan 11.

Clinical outcomes and predictive factors for response after the first course of corticosteroid therapy in patients with Crohn's disease.

Gut and liver

Duk Hwan Kim, Jae Hee Cheon, Jae Jun Park, Jin Young Yoon, Chang Mo Moon, Sung Pil Hong, Tae Il Kim, Won Ho Kim

Affiliations

  1. Department of Internal Medicine and Institute of Gastroenterology, Yonsei University College of Medicine, Seoul, Korea.

PMID: 23423699 PMCID: PMC3572321 DOI: 10.5009/gnl.2013.7.1.58

Abstract

BACKGROUND/AIMS: This study sought to determine the natural course of Crohn's disease (CD) and identify predictors that could indicate responsiveness to corticosteroid (CS) therapy.

METHODS: Patients with active CD who were treated with oral CS at a single institution between August 1994 and February 2008 were retrospectively reviewed. The clinical outcomes at 1 month, 4 months, and 1 year after the treatment, as well as clinical and biochemical parameters at the time of CS initiation, were evaluated.

RESULTS: A total of 96 patients with CD were enrolled. In this study, 37 patients achieved complete remission (38.5%), 49 achieved partial remission (51.0%), and 10 (10.4%) showed no response at 1 month after the initiation of CS treatment. At 4 months and 1 year after treatment, 66 (69.5%) and 47 (56.6%) patients showed prolonged response, 22 (23.2%) and 20 (24.1%) showed steroid dependency, and 7 (7.4%) and 16 (19.3%) showed refractoriness, respectively. Nonstricturing and nonpenetrating behaviors and a lower CD activity index demonstrated clinical significance for mid-term or mid- and long-term steroid responses, respectively.

CONCLUSIONS: The short-term response rate to initial oral CS therapy in CD was considerably high, but responsiveness thereafter showed a tendency to decrease with time. Clinical parameters reflecting mild inflammation were associated with responsiveness after CS treatment.

Keywords: Adrenal cortex hormones; Crohn disease; Inflammatory bowel diseases; Steroids

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