Display options
Cite
Ellis-Davies GC. A chemist and biologist talk to each other about caged neurotransmitters. Beilstein J Org Chem. 2013;9:64-73doi: 10.3762/bjoc.9.8.
Ellis-Davies, G. C. (2013). A chemist and biologist talk to each other about caged neurotransmitters. Beilstein journal of organic chemistry, 964-73. https://doi.org/10.3762/bjoc.9.8
Ellis-Davies, Graham Cr. "A chemist and biologist talk to each other about caged neurotransmitters." Beilstein journal of organic chemistry vol. 9 (2013): 64-73. doi: https://doi.org/10.3762/bjoc.9.8
Ellis-Davies GC. A chemist and biologist talk to each other about caged neurotransmitters. Beilstein J Org Chem. 2013;9:64-73. doi: 10.3762/bjoc.9.8. Epub 2013 Jan 11. PMID: 23399979; PMCID: PMC3566830.
Copy Download .nbib Format: NLM
Share it on

Beilstein J Org Chem. 2013;9:64-73. doi: 10.3762/bjoc.9.8. Epub 2013 Jan 11.

A chemist and biologist talk to each other about caged neurotransmitters.

Beilstein journal of organic chemistry

Graham Cr Ellis-Davies

Affiliations

  1. Department of Neuroscience, Mount Sinai School of Medicine, One Gustave Levy Place, New York, NY 10029, USA.

PMID: 23399979 PMCID: PMC3566830 DOI: 10.3762/bjoc.9.8

Abstract

Caged compounds are small organic molecules that can be photoactivated with brief pulses of light. They are widely used to study a great variety of biological processes by physiologists, cell biologists and neuroscientists. Initially made and invented by biologists in the late 1970s, they are now made mostly by chemists, often without any dialogue with the end users, the biologists. The idea for this review is to stimulate interaction between the two communities to further the creative development and application of these powerful optical probes.

Keywords: caged compounds; cell signaling; electrophysiology; neuronal currents; photolabile neurotransmitters; rates of reaction; receptor antagonism

References

  1. Biophys J. 1986 Nov;50(5):843-53 - PubMed
  2. Angew Chem Int Ed Engl. 2011 Dec 16;50(51):12156-82 - PubMed
  3. Chem Commun (Camb). 2010 Aug 7;46(29):5313-5 - PubMed
  4. J Physiol. 1993 Jun;465:1-8 - PubMed
  5. Nat Methods. 2007 Nov;4(11):943-50 - PubMed
  6. J Am Chem Soc. 2004 Apr 14;126(14):4581-95 - PubMed
  7. Biochemistry. 2007 May 8;46(18):5479-84 - PubMed
  8. Proc Natl Acad Sci U S A. 1997 Apr 1;94(7):3402-7 - PubMed
  9. Photochem Photobiol Sci. 2002 Jul;1(7):441-58 - PubMed
  10. Science. 1985 Jun 14;228(4705):1317-9 - PubMed
  11. J Neurosci. 2007 Dec 26;27(52):14231-8 - PubMed
  12. J Neurosci Methods. 2001 Nov 15;112(1):29-42 - PubMed
  13. J Org Chem. 2002 May 17;67(10):3474-8 - PubMed
  14. J Neurosci. 2011 Feb 23;31(8):2855-67 - PubMed
  15. Biochemistry. 2005 Mar 8;44(9):3316-26 - PubMed
  16. Science. 1992 Nov 27;258(5087):1498-501 - PubMed
  17. J Neurosci. 1999 Oct 15;19(20):8721-9 - PubMed
  18. Proc Natl Acad Sci U S A. 2003 Nov 25;100(24):13940-5 - PubMed
  19. Proc Natl Acad Sci U S A. 2011 Feb 1;108(5):2148-53 - PubMed
  20. J Neurosci Methods. 2009 May 30;180(1):9-21 - PubMed
  21. Biochemistry. 1978 May 16;17(10):1929-35 - PubMed
  22. Chembiochem. 2003 May 9;4(5):434-42 - PubMed
  23. Nature. 1984 Jul 5-11;310(5972):74-6 - PubMed
  24. Proc Natl Acad Sci U S A. 1994 Sep 13;91(19):8752-6 - PubMed
  25. J Neurosci Methods. 2006 Sep 30;156(1-2):351-9 - PubMed
  26. Angew Chem Int Ed Engl. 2001 Mar 16;40(6):1045-1048 - PubMed
  27. Neural Syst Circuits. 2011 Jan 26;1(1):2 - PubMed
  28. Front Neural Circuits. 2008 Aug 13;2:2 - PubMed
  29. Neuron. 1997 Sep;19(3):697-709 - PubMed
  30. J Neurosci. 2005 Jun 15;25(24):5670-9 - PubMed
  31. Biochemistry. 2000 May 9;39(18):5500-8 - PubMed
  32. Biophys J. 1993 Dec;65(6):2368-82 - PubMed
  33. Angew Chem Int Ed Engl. 2006 Jul 24;45(30):4900-21 - PubMed
  34. Biochemistry. 2005 May 17;44(19):7107-14 - PubMed
  35. Proc Natl Acad Sci U S A. 2006 Dec 5;103(49):18799-804 - PubMed
  36. Nat Methods. 2009 Dec;6(12):875-81 - PubMed
  37. J Neurosci. 2008 Jul 16;28(29):7399-411 - PubMed
  38. Rev Neurosci. 2004;15(3):167-83 - PubMed
  39. Methods Enzymol. 1998;291:307-48 - PubMed
  40. J Neurophysiol. 2004 Jul;92(1):609-21 - PubMed
  41. Org Lett. 2003 Dec 11;5(25):4867-70 - PubMed
  42. J Org Chem. 2004 Oct 15;69(21):7228-33 - PubMed
  43. J Org Chem. 2003 Oct 31;68(22):8361-7 - PubMed
  44. Biochemistry. 1999 Jun 15;38(24):7837-46 - PubMed
  45. J Biol Chem. 1997 Dec 26;272(52):32933-9 - PubMed
  46. Proc Natl Acad Sci U S A. 1999 Feb 16;96(4):1193-200 - PubMed
  47. Science. 2011 Sep 30;333(6051):1888-91 - PubMed
  48. Proc Natl Acad Sci U S A. 1993 Aug 15;90(16):7661-5 - PubMed
  49. Photochem Photobiol Sci. 2012 Mar;11(3):472-88 - PubMed
  50. Biochemistry. 2006 Apr 18;45(15):4915-26 - PubMed
  51. J Inorg Biochem. 2010 Apr;104(4):418-22 - PubMed
  52. Angew Chem Int Ed Engl. 2005 Dec 9;44(48):7887-91 - PubMed
  53. Biochemistry. 2000 Feb 29;39(8):2063-70 - PubMed
  54. Nat Methods. 2007 Aug;4(8):619-28 - PubMed
  55. J Neurosci Methods. 2008 Oct 30;175(1):44-57 - PubMed
  56. J Neurosci. 2007 Jun 20;27(25):6601-4 - PubMed
  57. Nat Neurosci. 2001 Nov;4(11):1086-92 - PubMed
  58. J Neurosci. 2005 Jun 29;25(26):6037-46 - PubMed
  59. J Med Chem. 1977 Jul;20(7):907-11 - PubMed
  60. J Neurosci. 2004 Oct 27;24(43):9572-9 - PubMed
  61. Biochemistry. 1994 Feb 15;33(6):1526-33 - PubMed
  62. Angew Chem Int Ed Engl. 2012 Feb 20;51(8):1840-3 - PubMed
  63. Neuron. 2000 Sep;27(3):447-59 - PubMed
  64. Nat Chem Biol. 2010 Apr;6(4):255-257 - PubMed
  65. J Physiol. 1984 Sep;354:605-24 - PubMed
  66. Neuron. 2004 Oct 28;44(3):483-93 - PubMed
  67. Curr Opin Chem Biol. 2005 Dec;9(6):570-5 - PubMed
  68. Chembiochem. 2006 Nov;7(11):1690-5 - PubMed
  69. Nat Neurosci. 2008 Nov;11(11):1256-8 - PubMed
  70. Proc Natl Acad Sci U S A. 1980 Dec;77(12):7237-41 - PubMed
  71. Angew Chem Int Ed Engl. 2008;47(49):9525-9 - PubMed
  72. Nature. 1982 Dec 23;300(5894):701-5 - PubMed
  73. J Neurosci Methods. 2005 Mar 15;142(1):1-9 - PubMed
  74. Chem Rev. 2008 May;108(5):1550-64 - PubMed
  75. J Physiol. 1984 Sep;354:577-604 - PubMed
  76. Chembiochem. 2007 Jan 2;8(1):89-97 - PubMed
  77. Photochem Photobiol Sci. 2008 Apr;7(4):423-32 - PubMed
  78. Biochemistry. 1989 Jan 10;28(1):49-55 - PubMed
  79. J Neurosci. 2003 Jul 23;23(16):6660-70 - PubMed
  80. J Neurosci Methods. 1995 Feb;56(2):203-15 - PubMed
  81. Neuron. 1995 Jan;14(1):19-28 - PubMed
  82. Nat Methods. 2010 Feb;7(2):123-5 - PubMed
  83. Nature. 1987 May 21-27;327(6119):249-52 - PubMed
  84. Front Neural Circuits. 2009 May 27;3:2 - PubMed
  85. Nat Methods. 2011 Dec 18;9(2):159-72 - PubMed
  86. Science. 2002 Jun 28;296(5577):2395-8 - PubMed
  87. Nat Methods. 2005 Dec;2(12):920-31 - PubMed
  88. Chembiochem. 2008 May 23;9(8):1303-7 - PubMed
  89. Photochem Photobiol. 2005 May-Jun;81(3):641-8 - PubMed
  90. Chem Commun (Camb). 2005 Aug 7;(29):3664-6 - PubMed
  91. Curr Biol. 2005 Dec 20;15(24):2279-84 - PubMed
  92. J Neurophysiol. 2008 Mar;99(3):1535-44 - PubMed
  93. PLoS One. 2008 Mar 19;3(3):e1796 - PubMed

Publication Types

Grant support