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Pendleton H, Alm R, Nordin Fredrikson G, et al. Antibodies against gonadotropin-releasing hormone in patients with posterior laryngitis. Drug Target Insights. 2013;7:1-8doi: 10.4137/DTI.S10837.
Pendleton, H., Alm, R., Nordin Fredrikson, G., & Ohlsson, B. (2013). Antibodies against gonadotropin-releasing hormone in patients with posterior laryngitis. Drug target insights, 71-8. https://doi.org/10.4137/DTI.S10837
Pendleton, Hillevi, et al. "Antibodies against gonadotropin-releasing hormone in patients with posterior laryngitis." Drug target insights vol. 7 (2013): 1-8. doi: https://doi.org/10.4137/DTI.S10837
Pendleton H, Alm R, Nordin Fredrikson G, Ohlsson B. Antibodies against gonadotropin-releasing hormone in patients with posterior laryngitis. Drug Target Insights. 2013;7:1-8. doi: 10.4137/DTI.S10837. Epub 2013 Jan 28. PMID: 23400339; PMCID: PMC3562083.
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Drug Target Insights. 2013;7:1-8. doi: 10.4137/DTI.S10837. Epub 2013 Jan 28.

Antibodies against gonadotropin-releasing hormone in patients with posterior laryngitis.

Drug target insights

Hillevi Pendleton, Ragnar Alm, Gunilla Nordin Fredrikson, Bodil Ohlsson

Affiliations

  1. Department of Clinical Sciences, Division of Otorhinolaryngology, Skåne University Hospital, Malmö, Lund University, Lund, Sweden.

PMID: 23400339 PMCID: PMC3562083 DOI: 10.4137/DTI.S10837

Abstract

Patients with functional gastrointestinal disorders express antibodies against gonadotropin-releasing hormone (GnRH) in serum. One common cause of posterior laryngitis (PL) is extra-esophageal reflux, but a functional etiology has also been suggested. The aim of this study was to scrutinize patients with PL with regard to the presence of GnRH antibodies and to examine the association between antibodies and symptoms and reflux. Consecutive PL patients were included after examination. Serum was analyzed for the presence of antibodies using an enzyme-linked immunosorbent assay (ELISA) method and expressed as relative units (RU). Two age- and gender-matched healthy subjects per case served as controls. The prevalence of IgM GnRH antibodies in patients was 35% compared with 28% in controls (P = 0.06), with higher levels in patients (0.8 (0.3-2.2) RU) than in controls (0.2 (0.1-0.6) RU) (P = 0.007). The corresponding IgG antibody prevalences were 43% and 4%, respectively (P = 0.001), with no difference in levels (P = 0.70). There was no association between antibodies and clinical findings.

Keywords: acid reflux; functional disorders; gonadotropin-releasing hormone; posterior laryngitis

References

  1. Gastroenterology. 2008 Feb;134(2):396-404 - PubMed
  2. Laryngoscope. 2006 Feb;116(2):254-60 - PubMed
  3. Laryngoscope. 1991 Apr;101(4 Pt 2 Suppl 53):1-78 - PubMed
  4. Dig Dis Sci. 1992 Nov;37(11):1761-8 - PubMed
  5. Gut. 2010 Apr;59(4):489-95 - PubMed
  6. Gut. 2011 Nov;60(11):1473-8 - PubMed
  7. Brain Res. 2010 Dec 10;1364:103-15 - PubMed
  8. Am J Physiol. 1992 Jan;262(1 Pt 1):G185-90 - PubMed
  9. Scand J Rheumatol. 2009;38(5):391-3 - PubMed
  10. Neurogastroenterol Motil. 2011 Nov;23(11):1000-6, e459 - PubMed
  11. Life Sci. 2001 Mar 2;68(15):1727-34 - PubMed
  12. Am J Gastroenterol. 1993 Jan;88(1):25-9 - PubMed
  13. Eur Arch Otorhinolaryngol. 2013 Jan;270(1):187-95 - PubMed
  14. Gastroenterol Clin North Am. 2008 Dec;37(4):827-43, viii - PubMed
  15. J Gastrointest Surg. 2001 May-Jun;5(3):260-5 - PubMed
  16. Gut. 2003 Dec;52(12):1671-7 - PubMed
  17. BMC Gastroenterol. 2010 May 20;10:48 - PubMed
  18. Aliment Pharmacol Ther. 2011 Apr;33 Suppl 1:1-71 - PubMed
  19. J Endocrinol Invest. 1982 Nov-Dec;5(6):393-6 - PubMed
  20. Clin Gastroenterol Hepatol. 2004 Sep;2(9):787-95 - PubMed
  21. Ann Otol Rhinol Laryngol Suppl. 2000 Oct;184:10-4 - PubMed
  22. Eur Arch Otorhinolaryngol. 2009 Mar;266(3):403-9 - PubMed
  23. Endocr Rev. 1988 Nov;9(4):379-86 - PubMed
  24. Scand J Gastroenterol. 2001 May;36(5):545-52 - PubMed
  25. Gastroenterol Clin North Am. 1997 Sep;26(3):467-86 - PubMed
  26. Eur Arch Otorhinolaryngol. 2010 Feb;267(2):171-9 - PubMed
  27. Comp Biochem Physiol B Biochem Mol Biol. 1996 Apr;113(4):817-21 - PubMed
  28. Dig Dis Sci. 2002 Mar;47(3):652-6 - PubMed

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