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Tchan M, Westbrook M, Wilcox G, et al. The management of pregnancy in maple syrup urine disease: experience with two patients. JIMD Rep. 2013;10:113-7doi: 10.1007/8904_2013_212.
Tchan, M., Westbrook, M., Wilcox, G., Cutler, R., Smith, N., Penman, R., Strauss, B. J., & Wilcken, B. (2013). The management of pregnancy in maple syrup urine disease: experience with two patients. JIMD reports, 10113-7. https://doi.org/10.1007/8904_2013_212
Tchan, Michel, et al. "The management of pregnancy in maple syrup urine disease: experience with two patients." JIMD reports vol. 10 (2013): 113-7. doi: https://doi.org/10.1007/8904_2013_212
Tchan M, Westbrook M, Wilcox G, Cutler R, Smith N, Penman R, Strauss BJ, Wilcken B. The management of pregnancy in maple syrup urine disease: experience with two patients. JIMD Rep. 2013;10:113-7. doi: 10.1007/8904_2013_212. Epub 2013 Feb 14. PMID: 23430812; PMCID: PMC3755568.
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JIMD Rep. 2013;10:113-7. doi: 10.1007/8904_2013_212. Epub 2013 Feb 14.

The management of pregnancy in maple syrup urine disease: experience with two patients.

JIMD reports

Michel Tchan, M Westbrook, G Wilcox, R Cutler, N Smith, R Penman, B J G Strauss, B Wilcken

Affiliations

  1. Department of Genetic Medicine, Westmead Hospital, 533, Westmead, NSW, 2145, Australia, [email protected].

PMID: 23430812 PMCID: PMC3755568 DOI: 10.1007/8904_2013_212

Abstract

We describe the management and outcomes of pregnancy in two women affected with Maple syrup urine disease (MSUD). Both patients had classical disease diagnosed in the newborn period and were managed with low-protein diets and supplements, although compliance was moderately poor throughout life. Both pregnancies were complicated by poor compliance and one patient had a metabolic decompensation, which included seizures and profound encephalopathy, at the end of the first trimester. Peri-partum management required a coordinated team approach including a high-calorie and low-protein diet. Both patients had elevated leucine levels in the post-partum period - one due to mastitis and the other due to poor dietary and supplement compliance combined with uterine involution. On later review, leucine had returned to pre-pregnancy levels. Both infants were unaffected and have made normal developmental progress in the subsequent 1 to 2 years.

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