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Pepe G, Tenore GC, Mastrocinque R, et al. Potential anticarcinogenic peptides from bovine milk. J Amino Acids. 2013;2013:939804doi: 10.1155/2013/939804.
Pepe, G., Tenore, G. C., Mastrocinque, R., Stusio, P., & Campiglia, P. (2013). Potential anticarcinogenic peptides from bovine milk. Journal of amino acids, 2013939804. https://doi.org/10.1155/2013/939804
Pepe, Giacomo, et al. "Potential anticarcinogenic peptides from bovine milk." Journal of amino acids vol. 2013 (2013): 939804. doi: https://doi.org/10.1155/2013/939804
Pepe G, Tenore GC, Mastrocinque R, Stusio P, Campiglia P. Potential anticarcinogenic peptides from bovine milk. J Amino Acids. 2013;2013:939804. doi: 10.1155/2013/939804. Epub 2013 Feb 26. PMID: 23533710; PMCID: PMC3600311.
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J Amino Acids. 2013;2013:939804. doi: 10.1155/2013/939804. Epub 2013 Feb 26.

Potential anticarcinogenic peptides from bovine milk.

Journal of amino acids

Giacomo Pepe, Gian Carlo Tenore, Raffaella Mastrocinque, Paola Stusio, Pietro Campiglia

Affiliations

  1. Dipartimento di Scienze Farmaceutiche e Biomediche, Università degli Studi di Salerno, Via Ponte Don Melillo, 84084 Fisciano, Italy.

PMID: 23533710 PMCID: PMC3600311 DOI: 10.1155/2013/939804

Abstract

BOVINE MILK POSSESSES A PROTEIN SYSTEM CONSTITUTED BY TWO MAJOR FAMILIES OF PROTEINS: caseins (insoluble) and whey proteins (soluble). Caseins ( α S1, α S2, β , and κ ) are the predominant phosphoproteins in the milk of ruminants, accounting for about 80% of total protein, while the whey proteins, representing approximately 20% of milk protein fraction, include β -lactoglobulin, α -lactalbumin, immunoglobulins, bovine serum albumin, bovine lactoferrin, and lactoperoxidase, together with other minor components. Different bioactivities have been associated with these proteins. In many cases, caseins and whey proteins act as precursors of bioactive peptides that are released, in the body, by enzymatic proteolysis during gastrointestinal digestion or during food processing. The biologically active peptides are of particular interest in food science and nutrition because they have been shown to play physiological roles, including opioid-like features, as well as immunomodulant, antihypertensive, antimicrobial, antiviral, and antioxidant activities. In recent years, research has focused its attention on the ability of these molecules to provide a prevention against the development of cancer. This paper presents an overview of antitumor activity of caseins and whey proteins and derived peptides.

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