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Sahin DG, Durak B, Gündüz E, et al. A New Case of dic(1;15)(p11;p11) in AML M1: Apropos of a Case and a Review of the Literature. Case Rep Genet. 2013;2013:462896doi: 10.1155/2013/462896.
Sahin, D. G., Durak, B., Gündüz, E., Artan, S., & Akay, O. M. (2013). A New Case of dic(1;15)(p11;p11) in AML M1: Apropos of a Case and a Review of the Literature. Case reports in genetics, 2013462896. https://doi.org/10.1155/2013/462896
Sahin, Deniz Gören, et al. "A New Case of dic(1;15)(p11;p11) in AML M1: Apropos of a Case and a Review of the Literature." Case reports in genetics vol. 2013 (2013): 462896. doi: https://doi.org/10.1155/2013/462896
Sahin DG, Durak B, Gündüz E, Artan S, Akay OM. A New Case of dic(1;15)(p11;p11) in AML M1: Apropos of a Case and a Review of the Literature. Case Rep Genet. 2013;2013:462896. doi: 10.1155/2013/462896. Epub 2013 Feb 27. PMID: 23533845; PMCID: PMC3600217.
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Case Rep Genet. 2013;2013:462896. doi: 10.1155/2013/462896. Epub 2013 Feb 27.

A New Case of dic(1;15)(p11;p11) in AML M1: Apropos of a Case and a Review of the Literature.

Case reports in genetics

Deniz Gören Sahin, Beyhan Durak, Eren Gündüz, Sevilhan Artan, Olga Meltem Akay

Affiliations

  1. Department of Hematology, School of Medicine, Eskisehir Osmangazi University, 26480 Eskisehir, Turkey.

PMID: 23533845 PMCID: PMC3600217 DOI: 10.1155/2013/462896

Abstract

Acute myelogenous leukemia (AML) develops as the consequence of a series of genetic changes in a hematopoietic precursor cell. Specific cytogenetic abnormalities have been identified by karyotype analysis in AML. One of the rare chromosomal abnormalities is a dicentric chromosome, which is defined as an aberrant chromosome having two centromeres. In the literature, a limited number of cases have been reported with dic(1;15) in myeloid disorders, but only one case has been reported with in acute megakaryoblastic leukemia. Herein, we report a case of acute myelogenous leukemia without maturation with a dic(1;15)(p11;p11), resulting in trisomy of the long arm of chromosome 1. To date, this is the second case of dic(1;15) in acute myelogenous leukemia and the first case in acute myeloblastic leukemia without maturation.

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