Display options
Cite
Gumbleton M, Kerr WG. Role of inositol phospholipid signaling in natural killer cell biology. Front Immunol. 2013;4:47doi: 10.3389/fimmu.2013.00047.
Gumbleton, M., & Kerr, W. G. (2013). Role of inositol phospholipid signaling in natural killer cell biology. Frontiers in immunology, 447. https://doi.org/10.3389/fimmu.2013.00047
Gumbleton, Matthew, and Kerr, William G. "Role of inositol phospholipid signaling in natural killer cell biology." Frontiers in immunology vol. 4 (2013): 47. doi: https://doi.org/10.3389/fimmu.2013.00047
Gumbleton M, Kerr WG. Role of inositol phospholipid signaling in natural killer cell biology. Front Immunol. 2013 Mar 06;4:47. doi: 10.3389/fimmu.2013.00047. eCollection 2013. PMID: 23508471; PMCID: PMC3589743.
Copy Download .nbib Format: NLM
Share it on

Front Immunol. 2013 Mar 06;4:47. doi: 10.3389/fimmu.2013.00047. eCollection 2013.

Role of inositol phospholipid signaling in natural killer cell biology.

Frontiers in immunology

Matthew Gumbleton, William G Kerr

Affiliations

  1. Department of Microbiology and Immunology, State University of New York Upstate Medical University Syracuse, NY, USA.

PMID: 23508471 PMCID: PMC3589743 DOI: 10.3389/fimmu.2013.00047

Abstract

Natural killer (NK) cells are important for host defense against malignancy and infection. At a cellular level NK cells are activated when signals from activating receptors exceed signaling from inhibitory receptors. At a molecular level NK cells undergo an education process to both prevent autoimmunity and acquire lytic capacity. Mouse models have shown important roles for inositol phospholipid signaling in lymphocytes. NK cells from mice with deletion in different members of the inositol phospholipid signaling pathway exhibit defects in development, NK cell repertoire expression and effector function. Here we review the current state of knowledge concerning the function of inositol phospholipid signaling components in NK cell biology.

Keywords: IFNγ; INPP4; PI3K; PIP5K; PTEN; SHIP; inositol phospholipid; natural killer cells

References

  1. Nat Rev Mol Cell Biol. 2010 May;11(5):329-41 - PubMed
  2. Blood. 2007 Sep 15;110(6):1942-9 - PubMed
  3. Biochem J. 1993 Dec 1;296 ( Pt 2):297-301 - PubMed
  4. Science. 2002 Mar 15;295(5562):2094-7 - PubMed
  5. J Immunol. 2002 Apr 1;168(7):3155-64 - PubMed
  6. J Biol Chem. 2008 Oct 31;283(44):29920-8 - PubMed
  7. Mol Med. 2012 Feb 10;18:65-75 - PubMed
  8. Nature. 1989 Sep 21;341(6239):197-205 - PubMed
  9. Ann N Y Acad Sci. 2011 Jan;1217:1-17 - PubMed
  10. Curr Biol. 1996 Apr 1;6(4):438-45 - PubMed
  11. Science. 1999 Jul 30;285(5428):730-2 - PubMed
  12. J Innate Immun. 2011;3(3):274-9 - PubMed
  13. J Biol Chem. 2002 Apr 12;277(15):13331-7 - PubMed
  14. Blood. 2001 Oct 1;98(7):2028-38 - PubMed
  15. Nat Immunol. 2003 Jun;4(6):557-64 - PubMed
  16. J Biol Chem. 1996 Sep 27;271(39):23611-4 - PubMed
  17. J Immunol. 2003 Jan 1;170(1):294-9 - PubMed
  18. Immunity. 2003 Jan;18(1):141-54 - PubMed
  19. J Biol Chem. 1996 Oct 25;271(43):26453-6 - PubMed
  20. Science. 2011 Jan 7;331(6013):44-9 - PubMed
  21. J Exp Med. 1994 Feb 1;179(2):551-8 - PubMed
  22. J Biol Chem. 1996 Dec 20;271(51):32937-43 - PubMed
  23. Cell Cycle. 2009 Oct 15;8(20):3307-10 - PubMed
  24. Proc Natl Acad Sci U S A. 1998 Sep 29;95(20):11810-5 - PubMed
  25. J Immunol. 2001 Oct 15;167(8):4358-67 - PubMed
  26. Blood. 2008 Apr 15;111(8):4165-72 - PubMed
  27. Proc Natl Acad Sci U S A. 2010 Feb 9;107(6):2556-61 - PubMed
  28. Am J Hum Genet. 1997 Dec;61(6):1254-60 - PubMed
  29. J Biol Chem. 1994 Feb 18;269(7):5241-8 - PubMed
  30. Nat Rev Immunol. 2006 Jul;6(7):520-31 - PubMed
  31. Science. 2001 Feb 9;291(5506):1047-51 - PubMed
  32. Blood. 2005 Jul 15;106(2):577-83 - PubMed
  33. Blood. 2012 Nov 29;120(23):4583-90 - PubMed
  34. Curr Opin Cell Biol. 2001 Aug;13(4):493-9 - PubMed
  35. EMBO J. 2000 Sep 1;19(17):4449-62 - PubMed
  36. Blood. 2007 Nov 1;110(9):3202-8 - PubMed
  37. Genes Immun. 2008 Sep;9(6):509-21 - PubMed
  38. J Immunol. 2010 Apr 1;184(7):3582-9 - PubMed
  39. PLoS Pathog. 2011 Sep;7(9):e1002265 - PubMed
  40. Nat Immunol. 2000 Nov;1(5):419-25 - PubMed
  41. Blood. 2005 Jun 15;105(12):4722-9 - PubMed
  42. Biochem Biophys Res Commun. 1997 Oct 29;239(3):697-700 - PubMed
  43. Science. 2002 May 31;296(5573):1655-7 - PubMed
  44. J Innate Immun. 2011;3(3):216-26 - PubMed
  45. J Cell Sci. 2011 Mar 1;124(Pt 5):820-30 - PubMed
  46. Immunobiology. 2002 Mar;205(1):74-94 - PubMed
  47. Biochim Biophys Acta. 1998 Dec 8;1436(1-2):87-104 - PubMed
  48. Nature. 1996 Sep 19;383(6597):263-6 - PubMed
  49. J Biol Chem. 2001 May 11;276(19):16201-6 - PubMed
  50. Nature. 2002 Nov 7;420(6911):85-9 - PubMed
  51. J Immunol Methods. 2009 Jan 30;340(2):158-63 - PubMed
  52. FASEB J. 2012 Aug;26(8):3163-77 - PubMed
  53. Blood. 2007 Apr 15;109(8):3316-24 - PubMed
  54. Blood. 2009 Mar 26;113(13):2924-33 - PubMed
  55. Blood. 2002 Dec 15;100(13):4581-9 - PubMed
  56. Genes Immun. 2008 Sep;9(6):522-35 - PubMed
  57. Nat Cell Biol. 2007 Jan;9(1):36-44 - PubMed
  58. Sci Signal. 2011 Nov 29;4(201):ra81 - PubMed
  59. J Exp Med. 1994 Oct 1;180(4):1427-35 - PubMed
  60. PLoS One. 2007 Mar 28;2(3):e326 - PubMed
  61. Immunity. 2007 Aug;27(2):214-27 - PubMed
  62. Immunity. 2003 Nov;19(5):669-78 - PubMed
  63. Biochem Soc Trans. 2007 Apr;35(Pt 2):183-5 - PubMed
  64. Cell Metab. 2011 Oct 5;14(4):466-77 - PubMed
  65. J Immunol. 2006 Jun 15;176(12):7165-9 - PubMed
  66. Genes Dev. 1996 May 1;10(9):1084-95 - PubMed
  67. J Physiol. 2007 Aug 1;582(Pt 3):967-75 - PubMed
  68. J Immunol. 2007 Dec 15;179(12):8009-15 - PubMed
  69. Proc Natl Acad Sci U S A. 1996 Apr 30;93(9):3947-52 - PubMed
  70. J Immunol. 2000 Aug 1;165(3):1210-9 - PubMed
  71. Science. 2001 Feb 9;291(5506):1051-5 - PubMed
  72. Nat Immunol. 2006 May;7(5):524-32 - PubMed
  73. J Biol Chem. 1997 Jun 13;272(24):15045-8 - PubMed
  74. Blood. 2003 Jan 1;101(1):236-44 - PubMed
  75. Nature. 2005 Dec 1;438(7068):605-11 - PubMed
  76. J Immunol. 1999 Mar 15;162(6):3249-55 - PubMed
  77. J Immunol. 2000 Jul 1;165(1):91-5 - PubMed
  78. J Innate Immun. 2011;3(3):249-57 - PubMed
  79. Proc Natl Acad Sci U S A. 1996 Feb 20;93(4):1689-93 - PubMed
  80. Cancer Res. 2005 Oct 1;65(19):9099-107 - PubMed
  81. Mol Biol Cell. 2008 Apr;19(4):1663-9 - PubMed
  82. J Immunol. 2010 May 1;184(9):5065-74 - PubMed
  83. Proc Natl Acad Sci U S A. 2009 Apr 7;106(14):5795-800 - PubMed
  84. Nature. 2002 Nov 7;420(6911):89-93 - PubMed
  85. J Exp Med. 2008 Sep 29;205(10):2419-35 - PubMed
  86. Blood. 2005 Apr 15;105(8):3011-8 - PubMed
  87. J Immunol. 2009 Jun 1;182(11):6933-42 - PubMed
  88. PLoS Biol. 2011 Sep;9(9):e1001151 - PubMed
  89. J Immunol. 2004 Sep 15;173(6):3653-9 - PubMed
  90. Blood. 2012 Mar 8;119(10):2252-62 - PubMed
  91. Nat Immunol. 2008 May;9(5):503-10 - PubMed
  92. J Immunol. 2007 Feb 1;178(3):1277-84 - PubMed
  93. Annu Rev Immunol. 1998;16:359-93 - PubMed
  94. Cell. 1995 Dec 15;83(6):1037-46 - PubMed
  95. J Biol Chem. 2012 Jul 6;287(28):23769-78 - PubMed
  96. J Biol Chem. 1998 Jul 17;273(29):18040-6 - PubMed
  97. Blood. 2009 Oct 8;114(15):3265-75 - PubMed
  98. J Clin Invest. 1999 Dec;104(12):1751-9 - PubMed
  99. Annu Rev Biophys Biomol Struct. 2002;31:151-75 - PubMed
  100. J Immunol. 1999 Sep 1;163(5):2628-33 - PubMed
  101. Blood. 2010 Aug 26;116(8):1272-9 - PubMed

Publication Types

Grant support