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Wi JK, Lee HJ, Kim EY, et al. Etiology of hypokalemic paralysis in Korea: data from a single center. Electrolyte Blood Press. 2012;10(1):18-25doi: 10.5049/EBP.2012.10.1.18.
Wi, J. K., Lee, H. J., Kim, E. Y., Cho, J. H., Chin, S. O., Rhee, S. Y., Moon, J. Y., Lee, S. H., Jeong, K. H., Ihm, C. G., & Lee, T. W. (2012). Etiology of hypokalemic paralysis in Korea: data from a single center. Electrolyte & blood pressure : E & BP, 10(1), 18-25. https://doi.org/10.5049/EBP.2012.10.1.18
Wi, Jung-Kook, et al. "Etiology of hypokalemic paralysis in Korea: data from a single center." Electrolyte & blood pressure : E & BP vol. 10,1 (2012): 18-25. doi: https://doi.org/10.5049/EBP.2012.10.1.18
Wi JK, Lee HJ, Kim EY, Cho JH, Chin SO, Rhee SY, Moon JY, Lee SH, Jeong KH, Ihm CG, Lee TW. Etiology of hypokalemic paralysis in Korea: data from a single center. Electrolyte Blood Press. 2012 Dec;10(1):18-25. doi: 10.5049/EBP.2012.10.1.18. Epub 2012 Dec 31. PMID: 23508689; PMCID: PMC3597914.
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Electrolyte Blood Press. 2012 Dec;10(1):18-25. doi: 10.5049/EBP.2012.10.1.18. Epub 2012 Dec 31.

Etiology of hypokalemic paralysis in Korea: data from a single center.

Electrolyte & blood pressure : E & BP

Jung-Kook Wi, Hong Joo Lee, Eun Young Kim, Joo Hee Cho, Sang Ouk Chin, Sang Youl Rhee, Ju-Young Moon, Sang-Ho Lee, Kyung-Hwan Jeong, Chun-Gyoo Ihm, Tae-Won Lee

Affiliations

  1. Department of Internal Medicine, College of Medicine, Kyung Hee University, Seoul, Korea.

PMID: 23508689 PMCID: PMC3597914 DOI: 10.5049/EBP.2012.10.1.18

Abstract

Recognizing the underlying causes of hypokalemic paralysis seems to be essential for the appropriate management of affected patients and their prevention of recurrent attacks. There is, however, a paucity of documented reports on the etiology of hypokalemic paralysis in Korea. We retrospectively analyzed 34 patients with acute flaccid weakness due to hypokalaemia who were admitted during the 5-year study period in order to determine the spectrum of hypokalemic paralysis in Korea and to identify the differences in clinical parameters all across the causes of hypokalemic paralysis. We divided those 34 patients into 3 groups; the 1(st) group, idiopathic hypokalemic periodic paralysis (HPP), the 2(nd), thyrotoxic periodic paralysis (TPP), and the 3rd group, secondary hypokalemic paralysis (HP) without TPP. Seven of the patients (20.6%) were diagnosed as idiopathic HPP considered the sporadic form, and 27 patients (79.4%) as secondary HP. Among the patients diagnosed as secondary HP, 16 patients (47.1%) had TPP. Patients of secondary hypokalemic paralysis without TPP required a longer recovery time compared with those who had either idiopathic HPP or TPP. This is due to the fact that patients of secondary HP had a significantly negative total body potassium balance, whereas idiopathic HPP and TPP were only associated with intracellular shift of potassium. Most of the TPP patients included in our study had overt thyrotoxicosis while 3 patients had subclinical thyrotoxicosis. This study shows that TPP is the most common cause of hypokalemic paralysis in Korea. And we suggest that doctors should consider the presence of TPP in patients of hypokalemic paralysis even if they clinically appear to be euthyroid state.

Keywords: Hypokalemic paralysis; Hypokalemic periodic paralysis; Thyrotoxic periodic paralysis

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