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Dev Cell. 2013 Mar 25;24(6):567-9. doi: 10.1016/j.devcel.2013.03.007.

Holding on and letting go: cadherin turnover in cell intercalation.

Developmental cell

Hitoshi Morita, Carl-Philipp Heisenberg

Affiliations

  1. Institute of Science and Technology Austria, Am Campus 1, 3400 Klosterneuburg, Austria.

PMID: 23537628 DOI: 10.1016/j.devcel.2013.03.007

Abstract

In zebrafish early development, blastoderm cells undergo extensive radial intercalations, triggering the spreading of the blastoderm over the yolk cell and thereby initiating embryonic body axis formation. Now reporting in Developmental Cell, Song et al. (2013) demonstrate a critical function for EGF-dependent E-cadherin endocytosis in promoting blastoderm cell intercalations.

Copyright © 2013 Elsevier Inc. All rights reserved.

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