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Kevin Ii DA, Meujo DA, Hamann MT. Polyether ionophores: broad-spectrum and promising biologically active molecules for the control of drug-resistant bacteria and parasites. Expert Opin Drug Discov. 2009;4(2):109-46doi: 10.1517/17460440802661443.
Kevin Ii, D. A., Meujo, D. A., & Hamann, M. T. (2009). Polyether ionophores: broad-spectrum and promising biologically active molecules for the control of drug-resistant bacteria and parasites. Expert opinion on drug discovery, 4(2), 109-46. https://doi.org/10.1517/17460440802661443
Kevin Ii, Dion A, et al. "Polyether ionophores: broad-spectrum and promising biologically active molecules for the control of drug-resistant bacteria and parasites." Expert opinion on drug discovery vol. 4,2 (2009): 109-46. doi: https://doi.org/10.1517/17460440802661443
Kevin Ii DA, Meujo DA, Hamann MT. Polyether ionophores: broad-spectrum and promising biologically active molecules for the control of drug-resistant bacteria and parasites. Expert Opin Drug Discov. 2009 Feb;4(2):109-46. doi: 10.1517/17460440802661443. PMID: 23480512; PMCID: PMC4896753.
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Expert Opin Drug Discov. 2009 Feb;4(2):109-46. doi: 10.1517/17460440802661443.

Polyether ionophores: broad-spectrum and promising biologically active molecules for the control of drug-resistant bacteria and parasites.

Expert opinion on drug discovery

Dion A Kevin Ii, Damaris Af Meujo, Mark T Hamann

Affiliations

  1. Professor of Pharmacy, Chemistry & Biochemistry University of Mississippi, National Center for Natural Products Research, CSO of Triton Biopharma, Department of Pharmacognosy, 407 Faser Hall, University, MS 38677, USA +1 662 915 5730 ; +1 662 915 6975 ; [email protected].

PMID: 23480512 PMCID: PMC4896753 DOI: 10.1517/17460440802661443

Abstract

BACKGROUND: As multidrug-resistant (MDR) pathogens continue to emerge, there is a substantial amount of pressure to identify new drug candidates. Carboxyl polyethers, also referred to as polyether antibiotics, are a unique class of compounds with outstanding potency against a variety of critical infectious disease targets including protozoa, bacteria and viruses. The characteristics of these molecules that are of key interest are their selectivity and high potency against several MDR etiological agents.

OBJECTIVE: Although many studies have been published about carboxyl polyether antibiotics, there are no recent reviews of this class of drugs. The purpose of this review is to provide the reader with an overview of the spectrum of activity of polyether antibiotics, their mechanism of action, toxicity and potential as drug candidates to combat drug-resistant infectious diseases.

CONCLUSION: Polyether ionophores show a high degree of promise for the potential control of drug-resistant bacterial and parasitic infections. Despite the long history of use of this class of drugs, very limited medicinal chemistry and drug optimization studies have been reported, thus leaving the door open to these opportunities in the future. Scifinder and PubMed were the main search engines used to locate articles relevant to the topic presented in the present review. Keywords used in our search were specific names of each of the 88 compounds presented in the review as well as more general terms such as polyethers, ionophores, carboxylic polyethers and polyether antibiotics.

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