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Ohwada T, Oka T, Kohchi A, et al. Differential effects of halothane and enflurane on end-systolic pressure-diameter relationship in anesthetized, mechanically ventilated dogs. J Anesth. 1994;8(3):339-43doi: 10.1007/BF02514662.
Ohwada, T., Oka, T., Kohchi, A., Inaba, H., Iijima, K., & Mizuguchi, T. (1994). Differential effects of halothane and enflurane on end-systolic pressure-diameter relationship in anesthetized, mechanically ventilated dogs. Journal of anesthesia, 8(3), 339-43. https://doi.org/10.1007/BF02514662
Ohwada, T, et al. "Differential effects of halothane and enflurane on end-systolic pressure-diameter relationship in anesthetized, mechanically ventilated dogs." Journal of anesthesia vol. 8,3 (1994): 339-43. doi: https://doi.org/10.1007/BF02514662
Ohwada T, Oka T, Kohchi A, Inaba H, Iijima K, Mizuguchi T. Differential effects of halothane and enflurane on end-systolic pressure-diameter relationship in anesthetized, mechanically ventilated dogs. J Anesth. 1994 Sep;8(3):339-43. doi: 10.1007/BF02514662. PMID: 23568124.
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J Anesth. 1994 Sep;8(3):339-43. doi: 10.1007/BF02514662.

Differential effects of halothane and enflurane on end-systolic pressure-diameter relationship in anesthetized, mechanically ventilated dogs.

Journal of anesthesia

T Ohwada, T Oka, A Kohchi, H Inaba, K Iijima, T Mizuguchi

Affiliations

  1. Department of Anesthesiology, Narita Red Cross Hospital, 90-1, Iida-cho, 286, Narita, Chiba, Japan.

PMID: 23568124 DOI: 10.1007/BF02514662

Abstract

To clarify the difference of negative inotropic effects, we evaluated the effects of 0, 0.5, and 1 MAC halothane and enflurane on systolic performance in anesthetized, mechanically ventilated, vagotomized dogs. Left ventricular myocardial contractility was assessed by the slope of the end-systolic pressure-diameter relationship (EES), which have been reported to be independent of alterations in preload and afterload but sensitive to changes in myocardial contractility. Both anesthetics decreased heart rate and dose-dependently decreased left ventricular systolic pressure. Enflurane decreased heart rate and left ventricular systolic pressure more than an equivalent MAC of halothane. Both anesthetics increased left ventricular end-diastolic diameter without any change in % shortening of the left ventricular internal diameter. TheEES was decreased to a similar extent at both 0.5 and 1 MAC halothane. TheEES was decreased with increasing concentrations of enflurane. TheEES was significantly larger (P<0.05) with 1 MAC of halothane than with 1 MAC enflurane. These results suggest that halothane preserves myocardial contractility better than enflurane in the presence of fentanyl.

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