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Johnson DK, Rinchik EM, Moustaid-Moussa N, et al. Phenotype screening for genetically determined age-onset disorders and increased longevity in ENU-mutagenized mice. Age (Dordr). 2005;27(1):75-90doi: 10.1007/s11357-005-4131-3.
Johnson, D. K., Rinchik, E. M., Moustaid-Moussa, N., Miller, D. R., Williams, R. W., Michaud, E. J., Jablonski, M. M., Elberger, A., Hamre, K., Smeyne, R., Chesler, E., & Goldowitz, D. (2005). Phenotype screening for genetically determined age-onset disorders and increased longevity in ENU-mutagenized mice. Age (Dordrecht, Netherlands), 27(1), 75-90. https://doi.org/10.1007/s11357-005-4131-3
Johnson, Dabney K, et al. "Phenotype screening for genetically determined age-onset disorders and increased longevity in ENU-mutagenized mice." Age (Dordrecht, Netherlands) vol. 27,1 (2005): 75-90. doi: https://doi.org/10.1007/s11357-005-4131-3
Johnson DK, Rinchik EM, Moustaid-Moussa N, Miller DR, Williams RW, Michaud EJ, Jablonski MM, Elberger A, Hamre K, Smeyne R, Chesler E, Goldowitz D. Phenotype screening for genetically determined age-onset disorders and increased longevity in ENU-mutagenized mice. Age (Dordr). 2005 Mar;27(1):75-90. doi: 10.1007/s11357-005-4131-3. Epub 2005 May 02. PMID: 23598606; PMCID: PMC3456097.
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Age (Dordr). 2005 Mar;27(1):75-90. doi: 10.1007/s11357-005-4131-3. Epub 2005 May 02.

Phenotype screening for genetically determined age-onset disorders and increased longevity in ENU-mutagenized mice.

Age (Dordrecht, Netherlands)

Dabney K Johnson, Eugene M Rinchik, Naima Moustaid-Moussa, Darla R Miller, Robert W Williams, Edward J Michaud, Monica M Jablonski, Andrea Elberger, Kristen Hamre, Richard Smeyne, Elissa Chesler, Daniel Goldowitz

Affiliations

  1. Life Sciences Division, Oak Ridge National Laboratory, PO Box 2008, Oak Ridge, TN 37831-6420 USA.

PMID: 23598606 PMCID: PMC3456097 DOI: 10.1007/s11357-005-4131-3

Abstract

With the goal of discovering genes that contribute to late-onset neurological and ocular disorders and also genes that extend the healthy life span in mammals, we are phenotyping mice carrying new mutations induced by the chemical N-ethyl-N-nitrosourea (ENU). The phenotyping plan includes basic behavioral, neurohistological, and vision testing in sibling cohorts of mice aged to 18 months, and then evaluation for markers of growth trajectory and stress response in these same cohorts aged up to 28 months. Statistical outliers are identified by comparison to test results of similar aged cohorts, and potential mutants are recovered for re-aging to confirm heritability of the phenotype.

Keywords: ENU mutations; age-onset; longevity; neurological disorders; phenotype-screening

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