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Pandey S, Sharma A, Dahia S, et al. Biochemical indicator of sickle cell disease: preliminary report from India. Indian J Clin Biochem. 2011;27(2):191-5doi: 10.1007/s12291-011-0162-y.
Pandey, S., Sharma, A., Dahia, S., Shah, V., Sharma, V., Mishra, R. M., Pandey, S., & Saxena, R. (2012). Biochemical indicator of sickle cell disease: preliminary report from India. Indian journal of clinical biochemistry : IJCB, 27(2), 191-5. https://doi.org/10.1007/s12291-011-0162-y
Pandey, S, et al. "Biochemical indicator of sickle cell disease: preliminary report from India." Indian journal of clinical biochemistry : IJCB vol. 27,2 (2012): 191-5. doi: https://doi.org/10.1007/s12291-011-0162-y
Pandey S, Sharma A, Dahia S, Shah V, Sharma V, Mishra RM, Pandey S, Saxena R. Biochemical indicator of sickle cell disease: preliminary report from India. Indian J Clin Biochem. 2012 Apr;27(2):191-5. doi: 10.1007/s12291-011-0162-y. Epub 2011 Sep 25. PMID: 23542695; PMCID: PMC3358379.
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Indian J Clin Biochem. 2012 Apr;27(2):191-5. doi: 10.1007/s12291-011-0162-y. Epub 2011 Sep 25.

Biochemical indicator of sickle cell disease: preliminary report from India.

Indian journal of clinical biochemistry : IJCB

S Pandey, A Sharma, S Dahia, V Shah, V Sharma, R M Mishra, Sw Pandey, R Saxena

Affiliations

  1. Department of Hematology, All India Institute of Medical Sciences (AIIMS), I.R.C.H. Building (1st Floor), Ansari Nagar, New Delhi, 110 029 India.

PMID: 23542695 PMCID: PMC3358379 DOI: 10.1007/s12291-011-0162-y

Abstract

Blood biochemistry has significant effect on pathophysiology of human body. Recently few studies found the association of biochemical abnormalities in sickle cell patients. Sickle cell disease showed clinical variability where African ancestors have severe phenotype than Indian sicklers. Our aim was to evaluate the biochemicals in sickle cell patients and their effect on severity. Here we present the comparative biochemical levels in sickle cell patients as well as controls. Sickle cell patients diagnosed by HPLC and biochemical analysis done by Beckman-auto analyzer. T test applied for statistical analysis. Result showed the renal abnormality lesser in patients and related biochemical within the normal range and statistically not significant. Electrolytes, hepatic enzymes, alkaline phosphatase and glucose were elevated and statistically significant (P value <0.05). Observation of the study concludes the biochemical abnormality play a significant role in sickle cell patient's physiopathology and can be used to management of the disease.

Keywords: Biochemical; High performance liquid chromatography; Sickle cell anaemia

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