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Senovilla L, Vitale I, Martins I, et al. An anticancer therapy-elicited immunosurveillance system that eliminates tetraploid cells. Oncoimmunology. 2013;2(1):e22409doi: 10.4161/onci.22409.
Senovilla, L., Vitale, I., Martins, I., Kepp, O., Galluzzi, L., Zitvogel, L., Castedo, M., & Kroemer, G. (2013). An anticancer therapy-elicited immunosurveillance system that eliminates tetraploid cells. Oncoimmunology, 2(1), e22409. https://doi.org/10.4161/onci.22409
Senovilla, Laura, et al. "An anticancer therapy-elicited immunosurveillance system that eliminates tetraploid cells." Oncoimmunology vol. 2,1 (2013): e22409. doi: https://doi.org/10.4161/onci.22409
Senovilla L, Vitale I, Martins I, Kepp O, Galluzzi L, Zitvogel L, Castedo M, Kroemer G. An anticancer therapy-elicited immunosurveillance system that eliminates tetraploid cells. Oncoimmunology. 2013 Jan 01;2(1):e22409. doi: 10.4161/onci.22409. PMID: 23482968; PMCID: PMC3583917.
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Oncoimmunology. 2013 Jan 01;2(1):e22409. doi: 10.4161/onci.22409.

An anticancer therapy-elicited immunosurveillance system that eliminates tetraploid cells.

Oncoimmunology

Laura Senovilla, Ilio Vitale, Isabelle Martins, Oliver Kepp, Lorenzo Galluzzi, Laurence Zitvogel, Maria Castedo, Guido Kroemer

Affiliations

  1. INSERM, U848; Villejuif, France ; Institut Gustave Roussy; Villejuif, France ; Université Paris Sud/Paris XI; Le Kremlin Bicêtre, France.

PMID: 23482968 PMCID: PMC3583917 DOI: 10.4161/onci.22409

Abstract

One of the driving forces of oncogenesis is tetraploidy, a duplication of the DNA content that, upon asymmetric cell division or progressive chromosome loss, can originate aneuploidy. Recent findings from our group indicate the existence of an immunosurveillance system that eliminates tetraploid cancer cells. We surmise that tetraploidy-inducing chemotherapeutic agents may elicit potent anticancer responses by re-activating this immunosurveillance system.

Keywords: HMGB1; breast carcinoma; calreticulin; hyperploidy; immunogenic cell death; mitotic catastrophe

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